Results 21 to 30 of about 18,149 (205)
Inhibition of galectins in cancer: Biological challenges for their clinical application
Frontiers in Immunology, 2023 Galectins play relevant roles in tumor development, progression and metastasis. Accordingly, galectins are certainly enticing targets for medical intervention in cancer. To date, however, clinical trials based on galectin inhibitors reported inconclusive
D. Laderach, D. Compagno
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Galectin functions in cancer-associated inflammation and thrombosis
Frontiers in Cardiovascular Medicine, 2023 Galectins are carbohydrate-binding proteins that regulate many cellular functions including proliferation, adhesion, migration, and phagocytosis. Increasing experimental and clinical evidence indicates that galectins influence many steps of cancer ...
Linus Kruk +7 more
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Galectins as modulators of receptor tyrosine kinases signaling in health and disease.
Cytokine & growth factor reviews, 2021 Receptor tyrosine kinases (RTKs) constitute a large group of cell surface proteins that mediate communication of cells with extracellular environment. RTKs recognize external signals and transfer information to the cell interior, modulating key cellular ...
Natalia Porębska +6 more
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Galectins: Double-edged Swords in the Cross-roads of Pregnancy Complications and Female Reproductive Tract Inflammation and Neoplasia [PDF]
Journal of Pathology and Translational Medicine, 2015 Galectins are an evolutionarily ancient and widely expressed family of lectins that have unique glycan-binding characteristics. They are pleiotropic regulators of key biological processes, such as cell growth, proliferation, differentiation, apoptosis ...
Nandor Gabor Than +9 more
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Galectins - Important players of the immune response to CNS parasitic infection
Brain, Behavior, & Immunity - Health, 2021 Galectins are a family of proteins that bind β-galactosides and play key roles in a variety of cellular processes including host defense and entry of parasites into the host cells. They have been well studied in hosts but less so in parasites.
Marta Maruszewska-Cheruiyot +2 more
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Galectins in Endothelial Cell Biology and Angiogenesis: The Basics
Biomolecules, 2021 Angiogenesis, the growth of new blood vessels out of existing vessels, is a complex and tightly regulated process. It is executed by the cells that cover the inner surface of the vasculature, i.e., the endothelial cells.
V. Thijssen
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Biomolecules, 2021 Galectins bind various pathogens through recognition of distinct carbohydrate structures. In this work, we examined the binding of four human galectins to the Gram-negative bacteria Klebsiella pneumoniae (Kpn) and non-typeable Haemophilus influenzae ...
María A. Campanero-Rhodes +7 more
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Frontiers in Neuroanatomy, 2021 Galectins are β-galactoside-binding lectins consisting of 15 members in mammals. Galectin-1,-3,-4,-8, and -9 are predominantly expressed in the central nervous system (CNS) and regulate various physiological and pathological events.
Junko Nio-Kobayashi, T. Itabashi
semanticscholar +1 more source
Cell Communication and Signaling, 2023 Fibroblast growth factors (FGFs) and their receptors (FGFRs) constitute complex signaling hubs that are crucial for the development and homeostasis of the human body.
Aleksandra Gedaj +9 more
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Hematology, 2023 Background Galectin (Gal) is considered a promising immune checkpoint molecule. More and more studies have shown that high expression levels of galectins in hematologic cancer are positively correlated with poor clinical prognosis.
Haotian Liu +4 more
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