Results 31 to 40 of about 18,149 (205)
Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins
Frontiers in Immunology, 2019 Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function.
Sandra M. Blois +6 more
doaj +1 more source
Brain Pathology, 2009 AbstractMalignant gliomas, especially glioblastomas, are associated with a dismal prognosis. Despite advances in diagnosis and treatment, glioblastoma patients still have a median survival expectancy of only 14 months. This poor prognosis can be at least partly explained by the fact that glioma cells diffusely infiltrate the brain parenchyma and ...
Le Mercier, Marie +4 more
openaire +2 more sources
Simulating cellular galectin networks by mixing galectins in vitro reveals synergistic activity
Biochemistry and Biophysics Reports, 2021 Background: Even though members of the family of adhesion/growth-regulatory galectins are increasingly detected to be co-expressed, they are still being routinely tested separately. The recent discovery of heterodimer formation among galectins-1, -3, and
Ruud P.M. Dings +4 more
doaj +1 more source
Chemokines and galectins form heterodimers to modulate inflammation
EMBO Reports, 2020 Chemokines and galectins are simultaneously upregulated and mediate leukocyte recruitment during inflammation. Until now, these effector molecules have been considered to function independently.
Veit Eckardt +21 more
semanticscholar +1 more source
World Journal of Surgical Oncology, 2022 Background and aim Galectins have been recently tackled by many researchers in the field of cancer due to their role in tumorigenesis, disease progression, and metastasis.
Radwa Mansour Mohamed +5 more
doaj +1 more source
Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy?
Frontiers in Oncology, 2022 The galectin family of proteins has high affinity with β-galactoside-containing glycans. These proteins participate in cell growth and differentiation, cell adhesion, cell signal transduction, cell apoptosis, and other cellular activities.
Yuanwei Shi +10 more
doaj +1 more source
Galectins in Intra- and Extracellular Vesicles
Biomolecules, 2020 Carbohydrate-binding galectins are expressed in various tissues of multicellular organisms. They are involved in autophagy, cell migration, immune response, inflammation, intracellular transport, and signaling.
S. Bänfer, R. Jacob
semanticscholar +1 more source
Galectin-1 and Galectin-3 in Chronic Pancreatitis [PDF]
Laboratory Investigation, 2000 Galectin-1 and galectin-3 have important functions in cell-cell interactions, cell adhesion to extracellular matrix, the organization of extracellular matrix, and tissue remodeling. To assess their potential role in chronic pancreatitis (CP), we examined their expression by Northern blot analysis, in situ hybridization, immunohistochemistry, and ...
L, Wang +7 more
openaire +2 more sources
Pharmaceuticals, 2021 Animal lectins are proteins with carbohydrate recognition activity. Galectins, the β-galactoside binding lectins, are expressed in various cells and have been reported to regulate several immunological and physiological responses.
Chih-Yen Lin +7 more
doaj +1 more source
Sweetening the hallmarks of cancer: Galectins as multifunctional mediators of tumor progression
Journal of Experimental Medicine, 2019 In this review, we dissect the role of galectins in shaping cellular circuitries governing each hallmark of tumors, illustrating relevant examples and highlighting novel opportunities for treating human cancer.
M. R. Girotti +3 more
semanticscholar +1 more source