Results 91 to 100 of about 390,833 (292)

Molecular mechanisms regulating formation, trafficking and processing of annular gap junctions [PDF]

, 2016
Internalization of gap junction plaques results in the formation of annular gap junction vesicles. The factors that regulate the coordinated internalization of the gap junction plaques to form annular gap junction vesicles, and the subsequent events ...
Bell, CL, Falk, MM, Kells Andrews, RM, Murray, SA   +3 more
core   +2 more sources

Gap Junctions in Development [PDF]

American Zoologist, 1986
The concept of a multicellular organism as an assemblage of cells that work together harmoniously for the good of the whole organism is well established. Over the past 15 years, however, it has become increasingly clear that the individual cells of multicellular animals are not as self-sufficient and independent of each other as once had been believed.
openaire   +3 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Dual Effects of Bilirubin on the Proliferation of Rat Renal NRK52E Cells and its Association with Gap Junctions

Dose-Response, 2013
Objective The effect of bilirubin on renal pathophysiology is controversial. This study aimed to observe the effects of bilirubin on the proliferation of normal rat renal tubular epithelial cell line (NRK52E) and its potential interplay with gap junction
Yanling Wang, Qiongfang Zhu, Chenfang Luo, Ailan Zhang, Ziqing Hei, Guangjie Su, Zhengyuan Xia, Michael G. Irwin   +7 more
doaj   +1 more source

Energy efficiency of information transmission by electrically coupled neurons

, 2012
The generation of spikes by neurons is energetically a costly process. This paper studies the consumption of energy and the information entropy in the signalling activity of a model neuron both when it is supposed isolated and when it is coupled to ...
Abarbanel, Abdelmalik Moujahid, Alicia d’Anjou, Attwell, Balasubramanian, Belykh, Cecilia Sarasola, Clarke, Connors, Dhamala, Donald, FitzHugh, Francisco J. Torrealdea, Galarreta, Hansel, Hasegawa, Hayashi, Herz, Hindmarsh, Hodgkin, Huerta, Kasischke, Kepler, Koch, Kolb, Lago-Fernandez, Laughlin, Lennie, Levy, Levy, Mackay, Morrison, N. Vélez de Mendizábal, Nagai, Nemenman, Olver, Ozden, Pinto, Rieke, Rose, Rose, Rose, Rose, Rosenblum, Roy, Rulkov, Sarasola, Schreiber, Selverston, Shannon, Siekevitz, Smith, Strong, Torrealdea, Torrealdea, Venaille, Veruki, Veruki, Vincent, Wu, Yoshioka   +60 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Diversity of Intercellular Communication Modes: A Cancer Biology Perspective

Cells
From the moment a cell is on the path to malignant transformation, its interaction with other cells from the microenvironment becomes altered. The flow of molecular information is at the heart of the cellular and systemic fate in tumors, and various ...
Thanzeela Ebrahim, Abdul Shukkur Ebrahim, Mustapha Kandouz   +2 more
doaj   +1 more source

Influence of Berberine on Cisplatin Antineoplastic Effect in A549 Cells

Chinese Journal of Lung Cancer, 2015
Background and objective Cisplatin is a standard first-line chemotherapeutic agents for treating advanced non-small cell lung cancer. Unfortunately, the clinical application cisplatin is restricted because it induces serious adverse reaction.
Guojun JIANG, Li LI, Xiaoxiang WU, Shuying DONG, Xuhui TONG   +4 more
doaj   +1 more source

Electron optics with ballistic graphene junctions

, 2016
Electrons transmitted across a ballistic semiconductor junction undergo refraction, analogous to light rays across an optical boundary. A pn junction theoretically provides the equivalent of a negative index medium, enabling novel electron optics such as
Chen, Shaowen, Dean, Cory R., Elahi, Mirza M., Gao, Yuanda, Ghosh, Avik W., Habib, K. M. Masum, Han, Zheng, Hone, James, Taniguchi, Takashi, Wang, Lei, Watanabe, Kenji, Wen, Bo   +11 more
core   +1 more source