Results 11 to 20 of about 2,836,933 (367)
Deficiency of transcription factor Brn4 disrupts cochlear gap junction plaques in a model of DFN3 non-syndromic deafness. [PDF]
PLoS ONE, 2014 Brn4, which encodes a POU transcription factor, is the gene responsible for DFN3, an X chromosome-linked, non-syndromic type of hearing loss. Brn4-deficient mice have a low endocochlear potential (EP), hearing loss, and ultrastructural alterations in ...
Yoshinobu Kidokoro +6 more
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Gap junction plasticity as a mechanism to regulate network-wide oscillations. [PDF]
PLoS Computational Biology, 2018 Cortical oscillations are thought to be involved in many cognitive functions and processes. Several mechanisms have been proposed to regulate oscillations. One prominent but understudied mechanism is gap junction coupling. Gap junctions are ubiquitous in
Guillaume Pernelle +2 more
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An Information Theoretical Analysis of Gap Junction Channels
IEEE Access, 2021 The propagation of molecules, ions and electrochemical signals in various cell types occurs through hundreds of gap junction channels. A gap junction channel is composed of hundreds of units which are further decomposed to hemichannels.
Farrokh Hejri +2 more
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The Journal of Cell Biology, 2005 In the 1960s there was adhesion and there was direct current transfer—a strange neuronal phenomenon whose mechanism was unknown. The two fields only gradually drifted together, but with the report by Revel and Karnovsky (1967) they were united around a distinct, structural correlate soon to ...
William A, Wells, Laura, Bonetta
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Circulation Research, 2006 See related article, pages 1216–1224 In the late 19th century microscopy and early physiological experimentation gave rise to the apparent paradox that although cardiac muscle is made up of individual cells, it behaves as a single continuous functional unit.
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Altered detrusor gap junction communications induce storage symptoms in bladder inflammation: a mouse cyclophosphamide-induced model of cystitis. [PDF]
PLoS ONE, 2014 Lower urinary tract symptoms (LUTS) include storage, voiding and post-micturition symptoms, featuring many urological diseases. Storage symptoms are the most frequent among these and associated with overactive bladder and non-bacterial bladder ...
Takeshi Okinami +8 more
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Decreases in Gap Junction Coupling Recovers Ca2+ and Insulin Secretion in Neonatal Diabetes Mellitus, Dependent on Beta Cell Heterogeneity and Noise. [PDF]
PLoS Computational Biology, 2016 Diabetes is caused by dysfunction to β-cells in the islets of Langerhans, disrupting insulin secretion and glucose homeostasis. Gap junction-mediated electrical coupling between β-cells in the islet plays a major role in coordinating a pulsatile ...
Aleena M Notary +4 more
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Frontiers in Physiology, 2022 In type 1 diabetes (T1D), islet dysfunction occurs prior to diabetes onset. Pro-inflammatory cytokines can disrupt insulin secretion and Ca2+ homeostasis.
Nikki L. Farnsworth +11 more
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Biochemistry and Biophysics Reports, 2023 Gap junctions, which are mainly composed of connexin units, play an indispensable role in cell morphogenesis, proliferation, migration, adhesion and differentiation of osteoblast lineage cells, and thus mediate bone development, homeostasis and disease ...
Tao Zuo +6 more
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Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons. [PDF]
PLoS Genetics, 2016 Gap junctions are present in both vertebrates and invertebrates from nematodes to mammals. Although the importance of gap junctions has been documented in many biological processes, the molecular mechanisms underlying gap junction dynamics remain unclear.
Lingfeng Meng, Chia-hui Chen, Dong Yan
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