Gap junction plasticity as a mechanism to regulate network-wide oscillations. [PDF]
PLoS Computational Biology, 2018 Cortical oscillations are thought to be involved in many cognitive functions and processes. Several mechanisms have been proposed to regulate oscillations. One prominent but understudied mechanism is gap junction coupling. Gap junctions are ubiquitous in
Guillaume Pernelle +2 more
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Cooperative cell-cell actin network remodeling to perform Gap junction endocytosis. [PDF]
Basic Clin Androl, 2023 Background The endocytosis of Gap junction plaques (GJP) requires cytoskeletal forces to internalize such large membranous structures. Actin, which partners the connexin proteins constituting Gap junctions and is located close to Annular Gap Junctions ...
Segretain D +5 more
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Deficiency of transcription factor Brn4 disrupts cochlear gap junction plaques in a model of DFN3 non-syndromic deafness. [PDF]
PLoS ONE, 2014 Brn4, which encodes a POU transcription factor, is the gene responsible for DFN3, an X chromosome-linked, non-syndromic type of hearing loss. Brn4-deficient mice have a low endocochlear potential (EP), hearing loss, and ultrastructural alterations in ...
Yoshinobu Kidokoro +6 more
doaj +1 more source
Gap resonance in the classical dynamics of the current-biased Josephson tunnel junctions [PDF]
Phys. Rev. Research vol. 3, issue 4, 043218 (2021), 2021 This work reports a novel time-domain expression for the current-response kernels of a Josephson tunnel junction between BCS superconductors with in general different energy gaps, and its use to simulate the classical dynamics of such junctions. The simulations show a dynamic regime characterized by the resonance between the Josephson oscillations and ...
arxiv +1 more source
An Electromagnetic-Flux-Distribution Model for the Analyses of Superconducting Josephson Junction Circuits and Quantum Phase-Slip Junction Circuits [PDF]
IEEE Transactions on Applied Superconductivity, pp. 1-6, 2022, 2021 Josephson junctions and the quantum phase-slip (QPS) junctions are two quantum circuit elements introduced by superconducting electronics to create various hybrid circuits. Josephson junctions bring the developments of superconducting quantum interference devices (SQUIDs) and single-flux quantum (SFQ) digital circuits; as the dual element of Josephson ...
arxiv +1 more source
An Information Theoretical Analysis of Gap Junction Channels
IEEE Access, 2021 The propagation of molecules, ions and electrochemical signals in various cell types occurs through hundreds of gap junction channels. A gap junction channel is composed of hundreds of units which are further decomposed to hemichannels.
Farrokh Hejri +2 more
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The Saint's International Dental Journal, 2020 Aim: The aim of the study was to assess the most common patterns of cementoenamel junction (CEJ) in permanent tooth and most common pattern of CEJ in males and females in permanent tooth.
Kundendu Arya Bishen +5 more
doaj +1 more source
Altered detrusor gap junction communications induce storage symptoms in bladder inflammation: a mouse cyclophosphamide-induced model of cystitis. [PDF]
PLoS ONE, 2014 Lower urinary tract symptoms (LUTS) include storage, voiding and post-micturition symptoms, featuring many urological diseases. Storage symptoms are the most frequent among these and associated with overactive bladder and non-bacterial bladder ...
Takeshi Okinami +8 more
doaj +1 more source
Decreases in Gap Junction Coupling Recovers Ca2+ and Insulin Secretion in Neonatal Diabetes Mellitus, Dependent on Beta Cell Heterogeneity and Noise. [PDF]
PLoS Computational Biology, 2016 Diabetes is caused by dysfunction to β-cells in the islets of Langerhans, disrupting insulin secretion and glucose homeostasis. Gap junction-mediated electrical coupling between β-cells in the islet plays a major role in coordinating a pulsatile ...
Aleena M Notary +4 more
doaj +1 more source
Frontiers in Physiology, 2022 In type 1 diabetes (T1D), islet dysfunction occurs prior to diabetes onset. Pro-inflammatory cytokines can disrupt insulin secretion and Ca2+ homeostasis.
Nikki L. Farnsworth +11 more
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