Results 271 to 280 of about 2,836,933 (367)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Calcium Role in Gap Junction Channel Gating: Direct Electrostatic or Calmodulin-Mediated? [PDF]

Int J Mol Sci
Peracchia C.
europepmc   +1 more source

Analysis of Trafficking, Stability and Function of Human Connexin 26 Gap Junction Channels with Deafness-Causing Mutations in the Fourth Transmembrane Helix

, 2013
Cinzia Ambrosi, Amy E. Walker, Adam DePriest, Angela C. Cone, Connie Lu, John Badger, I. Martha Skerrett, Gina E. Sosinsky   +7 more
openalex   +2 more sources

Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha -particle irradiated to nonirradiated cells.

Proceedings of the National Academy of Sciences of the United States of America, 2001
E. Azzam, S. Toledo, J. Little
semanticscholar   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Correction: Bee gomogenat enhances the healing process of diabetic wounds by orchestrating the connexin-pannexin gap junction proteins in streptozotocin-induced diabetic mice. [PDF]

Sci Rep
Sayed LH, Badr G, Omar HEM, Elghafar SKA, Sayed A.   +4 more
europepmc   +1 more source

Re-establishment of gap junctional intercellular communication (GJIC) between human endometrial carcinomas by prostaglandin E2

, 2020
Scott R. Schlemmer, David G. Kaufman
openalex   +1 more source

Animal cells connected by nanotubes can be electrically coupled through interposed gap-junction channels

Proceedings of the National Academy of Sciences of the United States of America, 2010
Xiang Wang, M. L. Veruki, N. V. Bukoreshtliev, E. Hartveit, H. Gerdes   +4 more
semanticscholar   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Gap junction intercellular communications regulates activation of SARM1 and protects against axonal degeneration. [PDF]

Cell Death Dis
Zhu WJ, Liu J, Li WH, Zhao ZY, Huang C, Yang JY, Lee HC, Zhao YJ.   +7 more
europepmc   +1 more source