Local accumulation time for diffusion in cells with gap junction coupling [PDF]
, 2022 In this paper we analyze the relaxation to steady-state of intracellular diffusion in a pair of cells with gap-junction coupling. Gap junctions are prevalent in most animal organs and tissues, providing a direct diffusion pathway for both electrical and chemical communication between cells.
arxiv +1 more source
Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons. [PDF]
PLoS Genetics, 2016 Gap junctions are present in both vertebrates and invertebrates from nematodes to mammals. Although the importance of gap junctions has been documented in many biological processes, the molecular mechanisms underlying gap junction dynamics remain unclear.
Lingfeng Meng, Chia-hui Chen, Dong Yan
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Blockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer's disease. [PDF]
PLoS ONE, 2011 Glutamate released by activated microglia induces excitotoxic neuronal death, which likely contributes to non-cell autonomous neuronal death in neurodegenerative diseases, including amyotrophic lateral sclerosis and Alzheimer's disease.
Hideyuki Takeuchi +18 more
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Alteration of cell junctions during viral infection
Thoracic Cancer, 2020 Cell junctions serve as a protective barrier for cells and provide an important channel for information transmission between cells and the surrounding environment.
Dan Dong, Wei Xie, Min Liu
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PLoS Biology, 2020 Gap junction connections between neurons play critical roles in the development of the nervous system. However, studies on the sensory experience-driven plasticity during the critical period rarely examine the involvement of gap junction connections.
Li Zhang, Qiwen Wu, Yifeng Zhang
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Thalamic modulation of cingulate seizure activity via the regulation of gap junctions in mice thalamocingulate slice. [PDF]
PLoS ONE, 2013 The thalamus is an important target for deep brain stimulation in the treatment of seizures. However, whether the modulatory effect of thalamic inputs on cortical seizures occurs through the modulation of gap junctions has not been previously studied ...
Wei-Pang Chang +2 more
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Biology, 2021 In a short-term model of hyperosmotic stress, primary murine astrocytes were stimulated with a hyperosmolar sucrose solution for five minutes. Astrocytic gap junctions, which are mainly composed of Connexin (Cx) 43, displayed immediate ultrastructural ...
Anja Beckmann +4 more
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Atrial fibrillation-linked germline GJA5/connexin40 mutants showed an increased hemichannel function. [PDF]
PLoS ONE, 2014 Mutations in GJA5 encoding the gap junction protein connexin40 (Cx40) have been linked to lone atrial fibrillation. Some of these mutants result in impaired gap junction function due to either abnormal connexin localization or impaired gap junction ...
Yiguo Sun +4 more
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Sex- and Age-Related Changes in Connexin 43 Expression in Normal Rat Bladder [PDF]
International Neurourology Journal, 2011 Purpose Gap junctions are intercellular channels to facilitate electrical and metabolic communication between adjacent cells. Connexin 43 is the most predominant type of connexin expressed on rat detrusor muscle cells.
Sung Ho Song +5 more
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Gap Junction-Dependent and -Independent Functions of Connexin43 in Biology
Biology, 2022 For the first time in animal evolution, the emergence of gap junctions allowed direct exchanges of cellular substances for communication between two cells.
Yi Zhu
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