Results 61 to 70 of about 2,836,933 (367)

Clinical Characteristics and Prognostic Risk Factors for Pediatric B‐Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐cell lymphoblastic lymphoma (B‐LBL) represents a rare variety of non‐Hodgkin lymphoma, with limited research on its biology, progression, and management. Methods A retrospective analysis was performed on the clinical characteristics of 256 patients aged ≤18 years who received treatment under the China Net Childhood Lymphoma (CNCL)‐
Zhijuan Liu, Jian Wang, Ling Jin, Yanlong Duan, Fu Li, Yueping Jia, Leping Zhang, Xiaojun Yuan, Wei Liu, Ying Liu, Ansheng Liu, Mincui Zheng, Yunpeng Dai, Lian Jiang, Lirong Sun, Xiaowen Zhai, Rong Liu, Chunju Zhou, Zifen Gao, Yonghong Zhang, Xiaomei Yang   +20 more
wiley   +1 more source

Analysis of the dominant mutation N188T of human connexin46 (hCx46) using concatenation and molecular dynamics simulation

FEBS Open Bio, 2019
Connexins (Cx) are proteins that form cell‐to‐cell gap junction channels. A mutation at position 188 in the second extracellular loop (E2) domain of hCx46 has been linked to an autosomal dominant zonular pulverulent cataract.
Patrik Schadzek, Yannick Stahl, Matthias Preller, Anaclet Ngezahayo   +3 more
doaj   +1 more source

An atrial-fibrillation-linked connexin40 mutant is retained in the endoplasmic reticulum and impairs the function of atrial gap-junction channels

Disease Models & Mechanisms, 2014
Connexin40 (Cx40)-containing gap-junction channels are expressed in the atrial myocardium and provide a low-resistance passage for rapid impulse propagation.
Yiguo Sun, Xiaoling Tong, Honghong Chen, Tao Huang, Qing Shao, Weixiong Huang, Dale W. Laird, Donglin Bai   +7 more
doaj   +1 more source

Ambegaokar-Baratoff relations of Josephson critical current in heterojunctions with multi-gap superconductors

, 2010
An extension of the Ambegaokar-Baratoff relation to a superconductor-insulator-superconductor (SIS) Josephson junction with multiple tunneling channels is derived.
Daisuke Inotani, Hideki Matsumoto, Hiroki Nakamura, J. H. Hinken, Masahiko Machida, Noriyuki Nakai, Tomio Koyama, V. V. Schmidt, Yoji Ohashi, Yukihiro Ota   +9 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Modeling the role of gap junctions between excitatory neurons in the developing visual cortex.

PLoS Computational Biology, 2021
Recent experiments in the developing mammalian visual cortex have revealed that gap junctions couple excitatory cells and potentially influence the formation of chemical synapses.
Jennifer Crodelle, David W McLaughlin
doaj   +1 more source

Gap Junctions and Cochlear Homeostasis [PDF]

, 2006
Gap junctions play a critical role in hearing and mutations in connexin genes cause a high incidence of human deafness. Pathogenesis mainly occurs in the cochlea, where gap junctions form extensive networks between non-sensory cells that can be divided ...
Kikuchi, T., Ngezahayo, Anaclet, White, T.W., Zhao, H.-B.   +3 more
core   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Expressional and functional involvement of gap junctions in aqueous humor outflow into the ocular trabecular meshwork of the anterior chamber

Molecular Vision, 2019
Purpose: The ocular trabecular meshwork (TM) responsible for aqueous humor (AH) drainage is crucial for regulating intraocular pressure (IOP) of the eye.
Hongxia, Yongzhen, Wenshi, Xia , Xian , Xiaojing , KeWei, Wei   +7 more
doaj  

Impaired astrocytic gap junction coupling and potassium buffering in a mouse model of tuberous sclerosis complex

Neurobiology of Disease, 2009
Abnormalities in astrocytes occur in the brains of patients with Tuberous Sclerosis Complex (TSC) and may contribute to the pathogenesis of neurological dysfunction in this disease. Here, we report that knock-out mice with Tsc1 gene inactivation in glia (
Lin Xu, Ling-Hui Zeng, Michael Wong
doaj   +1 more source