Results 71 to 80 of about 2,836,933 (367)
The Gap Junction Channel Protein Connexin 43 Is Covalently Modified and Regulated by SUMOylation*
Journal of Biological Chemistry, 2012 Background: Gap junctions are intercellular plasma membrane domains enriched in channels that provide direct communication between adjacent cells. Results: The gap junction channel protein connexin 43 is posttranslationally modified by SUMOylation ...
Ane Kjenseth +8 more
semanticscholar +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Relevance of Gap Junctions and Large Pore Channels in Traumatic Brain Injury
Frontiers in Physiology, 2014 In case of traumatic brain injury (TBI), occurrence of central nervous tissue damage is frequently aligned with local modulations of neuronal and glial gap junction channel expression levels.
Nora eProchnow
doaj +1 more source
Src Regulation of Cx43 Phosphorylation and Gap Junction Turnover
Biomolecules, 2020 The gap junction protein Connexin43 (Cx43) is highly regulated by phosphorylation at over a dozen sites by probably at least as many kinases. This Cx43 “kinome” plays an important role in gap junction assembly and turnover.
Joell L. Solan, Paul D. Lampe
doaj +1 more source
Connexin43: a protein from rat heart homologous to a gap junction protein from liver
Journal of Cell Biology, 1987 Northern blot analysis of rat heart mRNA probed with a cDNA coding for the principal polypeptide of rat liver gap junctions demonstrated a 3.0- kb band.
E. Beyer, D. Paul, D. Goodenough
semanticscholar +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Connexins evolved after early chordates lost innexin diversity
eLife, 2022 Gap junction channels are formed by two unrelated protein families. Non-chordates use the primordial innexins, while chordates use connexins that superseded the gap junction function of innexins.
Georg Welzel, Stefan Schuster
doaj +1 more source
A dual voltage clamp technique to study gap junction hemichannels in astrocytes cultured from neonatal rodent spinal cords [PDF]
, 2021 Juan Mauricio Garré +2 more
openalex +1 more source
An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots
FEBS Letters, EarlyView.This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino +7 more
wiley +1 more source
Cell Communication and Signaling, 2004 Background Connexin43 (Cx43) is an integral membrane protein that forms intercellular channels called gap junctions. Intercellular communication in the eye lens relies on an extensive network of gap junctions essential for the maintenance of lens ...
Pereira Paulo +2 more
doaj +1 more source