Results 101 to 110 of about 217,733 (290)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

The components of an electrical synapse as revealed by expansion microscopy of a single synaptic contact

eLife
Most nervous systems combine both transmitter-mediated and direct cell–cell communication, known as ‘chemical’ and ‘electrical’ synapses, respectively. Chemical synapses can be identified by their multiple structural components.
Sandra P Cárdenas-García, Sundas Ijaz, Alberto E Pereda   +2 more
doaj   +1 more source

Coexistence of a triplet nodal order-parameter and a singlet order-parameter at the interfaces of ferromagnet-superconductor Co/CoO/In junctions

, 2011
We present differential conductance measurements of Cobalt / Cobalt-Oxide / Indium planar junctions, 500nm x 500nm in size. The junctions span a wide range of barriers, from very low to a tunnel barrier.
A. F. Andreev, B. Almog, G. Deutscher, R. D. Parks, S. Hacohen-Gourgy, Y. Sharvin   +5 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

High efficiency switching using graphene based electron 'optics'

, 2011
The absence of a band-gap in graphene limits the gate modulation of its electron conductivity, both in regular graphene as well as in PN junctions, where electrostatic barriers prove transparent to Klein tunneling.
Ghosh, Avik, Sajjad, Redwan
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Circuit theory of multiple Andreev reflections in diffusive SNS junctions: the incoherent case

, 2000
The incoherent regime of Multiple Andreev Reflections (MAR) is studied in long diffusive SNS junctions at applied voltages larger than the Thouless energy.
A. Bardas, A. D. Zaikin, A. F. Volkov, A. F. Volkov, A. F. Volkov, A. Frydman, A. I. Larkin, A. I. Larkin, A. V. Zaitsev, A. V. Zaitsev, A. V. Zaitsev, C. J. Lambert, D. Averin, E. N. Bratus’, E. N. Bratus’, E. V. Bezuglyi, E. V. Bezuglyi, E. V. Bezuglyi, F. Zhou, G. B. Arnold, G. E. Blonder, G. Johansson, G. Wendin, H. Takayanagi, J. C. Cuevas, J. Kutchinsky, J. Kutchinsky, K. Flensberg, K. W. Lehnert, M. Kuhlmann, M. Octavio, M. Yu. Kupriyanov, N. Argaman, R. Taboryski, R. Taboryski, S. N. Artemenko, S. V. Lempitskii, T. H. Stoof, T. M. Klapwijk, U. Gunsenheimer, U. Zimmerman, V. S. Shumeiko, W. M. van Huffelen, Yu. V. Nazarov, Yu. V. Nazarov, Yu. V. Nazarov   +45 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Transport and spectroscopic properties of superconductor - ferromagnet - superconductor junctions of $La_{1.9}Sr_{0.1}CuO_4$ - $La_{0.67}Ca_{0.33}MnO_3$ - $La_{1.9}Sr_{0.1}CuO_4$

, 2011
Transport and Conductance spectra measurements of ramp-type junctions made of cuprate superconducting $La_{1.9}Sr_{0.1}CuO_4$ electrodes and a manganite ferromagnetic $La_{0.67}Ca_{0.33}MnO_3$ barrier are reported.
A. F. Andreev, A. F. Andreev, G. Koren, T. Kirzhner   +3 more
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source