Results 71 to 80 of about 217,733 (290)

Efficient encoding of motion is mediated by gap junctions in the fly visual system. [PDF]

PLoS Computational Biology, 2017
Understanding the computational implications of specific synaptic connectivity patterns is a fundamental goal in neuroscience. In particular, the computational role of ubiquitous electrical synapses operating via gap junctions remains elusive. In the fly
Siwei Wang, Alexander Borst, Noga Zaslavsky, Naftali Tishby, Idan Segev   +4 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Mixed electrical-chemical synapses in adult rat hippocampus are primarily glutamatergic and coupled by connexin-36

Frontiers in Neuroanatomy, 2012
Dendrodendritic electrical signaling via gap junctions is now an accepted feature of neuronal communication in the mammalian brain, whereas axodendritic and axosomatic gap junctions have rarely been described.
Farid eHamzei-Sichani, Kimberly G.V. Davidson, Thomas eYasumura, William G.M. Janssen, Susan L. Wearne, Patrick R. Hof, Patrick R. Hof, Roger D Traub, Rafael eGutierrez, Ole Petter Ottersen, John E. Rash, John E. Rash   +11 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Connexin30.2: in vitro interaction with connexin36 in HeLa cells and expression in AII amacrine cells and intrinsically photosensitive ganglion cells in the mouse retina

Frontiers in Molecular Neuroscience, 2016
Electrical coupling via gap junctions is an abundant phenomenon in the mammalian retina and occurs in all major cell types. Gap junction channels are assembled from different connexin subunits, and the connexin composition of the channel confers specific
Arndt eMeyer, Stephan eTetenborg, Helena eGreb, Jasmin eSegelken, Birthe eDorgau, Reto eWeiler, Sheriar Gustad Hormuzdi, Ulrike eJanssen-Bienhold, Karin eDedek   +8 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Threshold Resistance in the DC Josephson Effect

, 2006
We show that SIS Josephson junctions have a threshold resistance, above which the Josephson coupling and the supercurrents become extremely small, due to the shrinking of the Cooper pair size during the Josephson tunneling.
Kim, Yong-Jihn
core   +1 more source

Non-adiabatic Josephson Dynamics in Junctions with in-Gap Quasiparticles [PDF]

, 2010
Conventional models of Josephson junction dynamics rely on the absence of low energy quasiparticle states due to a large superconducting gap. With this assumption the quasiparticle degrees of freedom become "frozen out" and the phase difference becomes ...
Allen L., J. Michelsen, Kleinert H., Kulik I. O., Kulik I. O., Kulik I. O., Kulik I. O., Kulik I. O., Kulik I. O., Kulik I. O., Kulik I. O., Likharev K. K., Scalapino D. J., V. S. Shumeiko, Weiss U., Zaikin A. D., Zaikin A. D.   +16 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Quantitative evaluation of gap junctions during development of the brown adipose tissue.

Journal of Lipid Research, 1980
Gap junctions of rat brown adipose tissue (BAT) were studied with the freeze-fracture technique during development. The frequency and the mean area of gap junctions increased after birth, reached a maximal development during the functional phase of the ...
G Schneider-Picard, J L Carpentier, L Orci   +2 more
doaj   +1 more source