Results 201 to 210 of about 24,180 (354)

Gout and NLRP3 Inflammasome Biology

Arthritis &Rheumatology, Volume 77, Issue 10, Page 1317-1326, October 2025.
This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilization, and self‐resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal–induced inflammation is reviewed in detail.
Raewyn Poulsen, Nicola Dalbeth
wiley   +1 more source

WITHDRAWN: Role of Short-wavelength Blue Light in the Formation of Cataract and Expression of Caspase-1, -11 and Gasdermin D in rat Lens Epithelium Cells: Insight into the Novel Pathogenesis of Cataract. [PDF]

, 2019
Yamin Wang, Min Zhang, Ying Sun, Xiaohui Wang, Zhaowei Song, Huazhang Li, Kexin Liu, Zhijian Li   +7 more
openalex   +1 more source

The Ras GTPase‐activating‐like protein IQGAP1 bridges Gasdermin D to the ESCRT system to promote IL‐1β release via exosomes [PDF]

, 2022
Yun Liao, Xing Chen, William A. Miller-Little, Han Wang, Belinda Willard, Katarzyna Bulek, Junjie Zhao, Xiaoxia Li   +7 more
openalex   +1 more source

Gasdermin D cysteine residues synergistically control its palmitoylation-mediated membrane targeting and assembly

EMBO Journal
Gasdermin D (GSDMD) executes the cell death program of pyroptosis by assembling into oligomers that permeabilize the plasma membrane. Here, by single-molecule imaging, we elucidate the yet unclear mechanism of Gasdermin D pore assembly and the role of ...
Eleonora Margheritis, Shirin Kappelhoff, John Danial, Nadine Gehle, Wladislaw Kohl, Rainer Kurre, Ayelén González Montoro, Katia Cosentino   +7 more
semanticscholar   +1 more source

Epi‐Immunotherapy in Cancer Treatment: Mechanisms, Clinical Progress, and Future Directions

Cancer Innovation, Volume 4, Issue 5, October 2025.
Epigenetic regulation of tumor immune evasion and synergistic anticancer strategies via epigenetic‐immunotherapy integration. ABSTRACT Cancer immunotherapy is a groundbreaking therapeutic strategy, yet it continues to face significant challenges, including limited overall response rates and treatment resistance.
Nannan Lu, Guanghua Rong, Weidong Han
wiley   +1 more source

Insights into Gasdermin D activation from the crystal structure of its C-terminal domain

, 2017
Leonie Anton, Lorenzo Sborgi, Sebastian Hiller, Petr Brož, Timm Maier   +4 more
openalex   +1 more source

A pan-cancer analysis of molecular characteristics and oncogenic role of gasdermins [PDF]

, 2022
Mingchao Mu, Qiaoling Yu, Qin Zhang, Jing Guo, Xingjie Wang, Xuejun Sun, Junhui Yu   +6 more
openalex   +1 more source

LAG3 as a Tumor Suppressor and Immune Regulator in Cervical Cancer: From Functional Validation to Therapeutic Strategy

Cancer Medicine, Volume 14, Issue 19, October 2025.
Studies have found that the molecular typing of pyroptostic‐related genes (PRGs) in cervical cancer can predict prognosis, and the GNAZ/LAG3/IL1B/CA2/SPRR3 risk scoring model has been constructed. Experiments have confirmed that LAG3 inhibits tumor progression by regulating Treg and CD8+ T cells, providing a new target for immunotherapy.
Shijie Yao, Siming Chen, Shimeng Wan, Anjin Wang, Ziyan Liang, Xuelian Liu, Yang Gao, Hongbing Cai   +7 more
wiley   +1 more source

NcRNA Regulated Pyroptosis in Liver Diseases and Traditional Chinese Medicine Intervention: A Narrative Review

Journal of Inflammation Research
Jiasheng Deng,1,* Le Qin,2,* Sulang Qin,3,* Ruisheng Wu,1 Guidong Huang,1 Yibin Fang,4 Lanlan Huang,4 Zhipin Zhou4 1School of Pharmacy, Guangxi University of Chinese Medicine, Nanning, Guangxi, 530200, People’s Republic of China; 2Department ...
Deng J, Qin L, Qin S, Wu R, Huang G, Fang Y, Huang L, Zhou Z   +7 more
doaj  

Inhibition of Gasdermin D-Mediated Pyroptosis Attenuates the Severity of Seizures and Astroglial Damage in Kainic Acid-Induced Epileptic Mice [PDF]

, 2022
Lu Xia, Lu Liu, Yiying Cai, Yiying Zhang, Fangchao Tong, Qiang Wang, Jing Ding, Xin Wang   +7 more
openalex   +1 more source