DL-3-n-Butylphthalide Attenuates Myocardial Hypertrophy by Targeting Gasdermin D and Inhibiting Gasdermin D Mediated Inflammation [PDF]
Frontiers in Pharmacology, 2021 Pressure overload leads to a hypertrophic milieu that produces deleterious cardiac dysfunction. Inflammation is a key pathophysiological mechanism underpinning myocardial hypertrophy.
Bingjiang Han +6 more
doaj +4 more sources
Investigation of the effect of serum gasdermin d levels on clinical course and mortality in patients with covid-19 [PDF]
BMC Infectious DiseasesBackground Cytokine storm is among the pathogenetic mechanisms in patients with severe Coronavirus Disease 2019 (COVID-19). Pyroptosis, a form of programmed cell death, is thought to play an important role in cytokine storms.
Merve Turker Isik +2 more
doaj +4 more sources
Acta Pharmaceutica Sinica B, 2021 Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to induce strong inflammatory responses that defend the host against microbe infection.
Brandon E. Burdette +3 more
doaj +3 more sources
Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation [PDF]
Nature Communications, 2019 Gasdermins mediate lytic cell death by forming pores in the plasma membrane. Here the authors show that gasdermins also permeabilize mitochondrial membrane, thereby facilitating intrinsic apoptosis pathway, downstream of apoptotic (Gasdermin E) and ...
Corey Rogers +5 more
doaj +4 more sources
Indirect regulation of HMGB1 release by gasdermin D [PDF]
Nature Communications, 2020 HMGB1 is an inflammatory mediator released by a variety of cell types. Here, the authors show that unlike IL-1β, HMGB1 is released non-specifically following cell lysis.
Allen Volchuk +4 more
doaj +3 more sources
Gasdermin D pore-forming activity is redox-sensitive
Cell Reports, 2023 Summary: Reactive oxygen species (ROS) regulate the activities of inflammasomes, which are innate immune signaling organelles that induce pyroptosis. The mechanisms by which ROS control inflammasome activities are unclear and may be multifaceted. Herein,
Pascal Devant +8 more
doaj +3 more sources
Vastly different energy landscapes of the membrane insertions of monomeric gasdermin D and A3 [PDF]
Communications ChemistryGasdermin D and gasdermin A3 belong to the same family of pore-forming proteins and executors of pyroptosis, a form of programmed cell death. To unveil the process of their pore formation, we examine the energy landscapes upon insertion of the gasdermin ...
Viktoria Korn, Kristyna Pluhackova
doaj +2 more sources
Pyroptosis inhibiting nanobodies block Gasdermin D pore formation
Nature Communications, 2023 Human Gasdermin D (GSDMD) is a key mediator of pyroptosis, a pro-inflammatory form of cell death occurring downstream of inflammasome activation as part of the innate immune defence.
Anja Kopp +6 more
doaj +4 more sources
Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors
Frontiers in Immunology, 2023 Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important self-protection mechanisms against stimuli and infections. Hosts can defend against intracellular bacterial infections by inducing cell pyroptosis, which triggers the ...
Zhen Dai +5 more
doaj +3 more sources
Gasdermin D: A New Inflammatory Biomarker in Assessing Clinical Disease Activity in Crohn’s Disease [PDF]
The Turkish Journal of GastroenterologyBackground/Aims: Crohn’s disease (CD) is an inflammatory, progressive disorder requiring monitoring of treatment response and disease course. Gasdermin D (GSDMD), a protein belonging to the gasdermin protein family, plays a role in inflammatory cell ...
Osman Cagin Buldukoglu +9 more
doaj +2 more sources