Gasdermin D-mediated neutrophil pyroptosis drives inflammation in psoriasis. [PDF]
ElifeAbstract Psoriasis is a multifactorial immune-mediated inflammatory disease. Its pathogenesis involves abnormal accumulation of neutrophils and T-cell related abnormalities. Pyroptosis is a type of regulated cell death associated with innate immunity, but its role in psoriasis is unclear. In this study, we found that gasdermin D (Gsdmd)
Liu J +7 more
europepmc +6 more sources
IL-36γ is secreted through an unconventional pathway using the Gasdermin D and P2X7R membrane pores [PDF]
Frontiers in Immunology, 2022 Mucosal innate immunity functions as the first line of defense against invading pathogens. Members of the IL-1 family are key cytokines upregulated in the inflamed mucosa.
Laura D. Manzanares-Meza +10 more
doaj +2 more sources
Sublytic gasdermin-D pores captured in atomistic molecular simulations [PDF]
eLife, 2022 Abstract Gasdermin-D (GSDMD) is the ultimate effector of pyroptosis, a form of programmed cell death associated with pathogen invasion and inflammation. After proteolytic cleavage by caspases activated by the inflammasome, the GSDMD N-terminal domain (GSDMD NT ) assembles on the ...
Stefan L Schaefer, Gerhard Hummer
openaire +6 more sources
Gasdermin D Deficiency Limits the Transition of Atherosclerotic Plaques to an Inflammatory Phenotype in ApoE Knock-Out Mice [PDF]
Biomedicines, 2022 Gasdermin D (GSDMD) is the key executor of pyroptotic cell death. Recent studies suggest that GSDMD-mediated pyroptosis is involved in atherosclerotic plaque destabilization. We report that cleaved GSDMD is expressed in macrophage- and smooth muscle cell-
Pauline Puylaert +7 more
doaj +2 more sources
Gasdermin D mutation protects against renal ischemia reperfusion injury. [PDF]
Physiol RepAbstractPyroptosis, the most inflammatory form of cell death, is dependent on membrane pore formation governed by the assembly of cleaved Gasdermin D (GSDMD). We hypothesized that regulated necrosis pathways are crucial in the pathophysiology of acute kidney injury (AKI).
Li JSY +7 more
europepmc +4 more sources
Cyclodextrin attenuates atherosclerosis by diminishing gasdermin D (GSDMD)-mediated pyroptosis [PDF]
Scientific ReportsPyroptosis, a programmed form of cell death, typically increases during the atherosclerosis development. Cyclodextrins are oligosaccharides with anti-atherosclerotic properties.
Mohammad Ismail Hajary Sagor +8 more
doaj +2 more sources
Targeting gasdermin D and neutrophil mobilization for cardioprotection
Metabolism Open, 2021 Maria Dalamaga, Junli Liu
doaj +4 more sources
Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death [PDF]
Cell Reports, 2018 Summary: Gasdermin D (GSDMD) is considered a proinflammatory factor that mediates pyroptosis in macrophages to protect hosts from intracellular bacteria.
Hiroto Kambara +14 more
doaj +4 more sources
Molecular mechanism of bovine Gasdermin D-mediated pyroptosis
Veterinary ResearchPyroptosis is a form of programmed cell death characterized by cell swelling, pore formation in the plasma membrane, lysis, and releases of cytoplasmic contents.
Zhendong Ge +11 more
doaj +3 more sources
Multiple sclerosis: the NLRP3 inflammasome, gasdermin D, and therapeutics. [PDF]
Ann Transl MedMultiple sclerosis (MS) stands as a chronic inflammatory disease characterized by its neurodegenerative impacts on the central nervous system. The complexity of MS and the significant challenges it poses to patients have made the exploration of effective treatments a crucial area of research.
Brint A +3 more
europepmc +3 more sources