Results 21 to 30 of about 20,660 (301)

Gasdermin D cysteine residues synergistically control its palmitoylation-mediated membrane targeting and assembly [PDF]

The EMBO Journal
Gasdermin D (GSDMD) executes the cell death program of pyroptosis by assembling into oligomers that permeabilize the plasma membrane. Here, by single-molecule imaging, we elucidate the yet unclear mechanism of Gasdermin D pore assembly and the role of ...
Eleonora Margheritis, Shirin Kappelhoff, John Danial, Nadine Gehle, Wladislaw Kohl, Rainer Kurre, Ayelén González Montoro, Katia Cosentino   +7 more
doaj   +2 more sources

Gasdermin D: A potential mediator and prognostic marker of bladder cancer

Frontiers in Molecular Biosciences, 2022
Background: Bladder cancer is considered one of the commonest widespread cancers, its presentation ranges from non-muscle invasive form to being muscle-invasive. The gasdermin family of proteins consists of six proteins.
Randa El-Gamal, Randa El-Gamal, Mona Abdelrahim, Mohamed El-Sherbiny, Eman T. Enan, Mohammad El-Nablaway, Mohammad El-Nablaway   +6 more
doaj   +1 more source

Gasdermin D and Beyond – Gasdermin-mediated Pyroptosis in Bacterial Infections

Journal of Molecular Biology, 2022
The discovery of pyroptosis and its subsequent implications in infection and immunity has uncovered a new angle of host-defence against pathogen assault. At its most simple, gasdermin-mediated pyroptosis in bacterial infection would be expected to remove pathogens from the relative safety of the cytosol or pathogen containing vacuole/phagosome whilst ...
Lee M, Booty, Clare E, Bryant
openaire   +2 more sources

Gasdermin D and TMA.

Blood
Xia L.
europepmc   +2 more sources

Gasdermin-D activation promotes NLRP3 activation and host resistance to Leishmania infection

Nature Communications, 2023
Here, de Sá et al. show that Gasdermin-D is transiently activated in Leishmania-infected macrophages and promotes NLRP3 inflammasome activation, but not cell death.
Keyla S. G. de Sá, Luana A. Amaral, Tamara S. Rodrigues, Adriene Y. Ishimoto, Warrison A. C. de Andrade, Leticia de Almeida, Felipe Freitas-Castro, Sabrina S. Batah, Sergio C. Oliveira, Mônica T. Pastorello, Alexandre T. Fabro, Dario S. Zamboni   +11 more
doaj   +1 more source

Caspase-11-Gasdermin D-Mediated Pyroptosis Is Involved in the Pathogenesis of Atherosclerosis

Frontiers in Pharmacology, 2021
Background: Pyroptosis is a form of cell death triggered by proinflammatory signals. Recent studies have reported that oxidized phospholipids function as caspase-11 agonists to induce noncanonical inflammasome activation in immune cells. As the levels of
Mengqing Jiang, Xuejing Sun, Suzhen Liu, Yan Tang, Yunming Shi, Yuanyuan Bai, Yujie Wang, Qiong Yang, Qize Yang, Weihong Jiang, Hong Yuan, Qixia Jiang, Jingjing Cai, Jingjing Cai   +13 more
doaj   +1 more source

E3 ubiquitin ligase SYVN1 is a key positive regulator for GSDMD-mediated pyroptosis

Cell Death and Disease, 2022
Gasdermin D (GSDMD) participates in the activation of inflammasomes and pyroptosis. Meanwhile, ubiquitination strictly regulates inflammatory responses. However, how ubiquitination regulates Gasdermin D activity is not well understood.
Yuhua Shi, Yang Yang, Weilv Xu, Dongyun Shi, Wei Xu, Xinyu Fu, Qian Lv, Jie Xia, Fushan Shi   +8 more
doaj   +1 more source

Autophagy May Allow a Cell to Forbear Pyroptosis When Confronted With Cytosol-Invasive Bacteria

Frontiers in Immunology, 2022
Inflammatory caspases detect cytosol-invasive Gram-negative bacteria by monitoring for the presence of LPS in the cytosol. This should provide defense against the cytosol-invasive Burkholderia and Shigella species by lysing the infected cell via ...
Carissa K. Harvest, Carissa K. Harvest, Carissa K. Harvest, Carissa K. Harvest, Edward A. Miao, Edward A. Miao, Edward A. Miao   +6 more
doaj   +1 more source

Gasdermin D-Mediated Pyroptosis Exerts Two Opposite Effects of Resisting Enzymatic Digestion and Expanding Inflammatory Response in Acute Pancreatitis. [PDF]

Adv Sci (Weinh)
Liu C, Liang N, Wu C, Qiu Z, Huang Q, Wei X, Zhang S, Lei S, Yang T, Wang G, Wang Q.   +10 more
europepmc   +3 more sources

Protective effects of IRG1/itaconate on acute colitis through the inhibition of gasdermins-mediated pyroptosis and inflammation response

Genes and Diseases, 2023
Inflammatory bowel disease (IBD) is a chronic relapsing gastrointestinal disorder, while the treatment effect is not satisfactory. Immune responsive gene 1 (IRG1) is a highly expressed gene in macrophage in response to inflammatory response and catalyzes
Wenchang Yang, Yaxin Wang, Tao Wang, Chengguo Li, Liang Shi, Peng Zhang, Yuping Yin, Kaixiong Tao, Ruidong Li   +8 more
doaj   +1 more source