Results 141 to 150 of about 15,677 (174)

Inducing Pyroptosis via Gasdermin B and Gasdermin E Cleavage

2023
Gasdermin B (GSDMB) and gasdermin E (GSDME) are two members of the gasdermin family, which shares a conservative gasdermin-N domain capable of executing pyroptotic cell death, through perforating the plasma membrane from inside of the cell. Both GSDMB and GSDME are autoinhibited in the resting stage and require proteolytic cleavage to unleash the pore ...
Zhiwei, Zhou, Yupeng, Wang, Feng, Shao
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Caspase‐3 and gasdermin E mediate macrophage pyroptosis in periodontitis

Journal of Periodontal Research, 2023
AbstractBackground and ObjectivesPeriodontitis is a chronic inflammatory disease linked to pyroptosis, an inflammatory cell death process. Macrophages are essential for maintaining microenvironment homeostasis, which is crucial for periodontal health.
Xiangru Gao, Shuhan Li, Wenxuan Wang, Xiangyan Zhang, Xinbo Yu, Chun Fan, Wei Li, Caixiu Yang, Lei Wang, Qiuxia Ji   +9 more
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Zebrafish gasdermin E cleavage-engaged pyroptosis by inflammatory and apoptotic caspases

Developmental & Comparative Immunology, 2021
As the executor of pyroptosis known to date, gasdermins (GSDMs), consists of GSDMA, GSDMB, GSDMC, GSDMD, GSDME and pejvakin, might play critical roles in anti-bacterial infection as well as inflammatory diseases. However, zebrafish only harbors a pair of Gsdme (Gsdmea/b), and their activation mechanisms remain largely unknown.
Hao Chen, Xiaomin Wu, Zhaoyan Gu, Shouwen Chen, Xiangshan Zhou, Yuanxing Zhang, Qin Liu, Zhuang Wang, Dahai Yang   +8 more
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Molecular mechanisms and therapeutic relevance of gasdermin E in human diseases

Cellular Signalling, 2022
Gasdermin E (GSDME) is one of the main members of the GSDM family and is originally involved in hereditary hearing loss. Recent studies have reported that GSDME expression is epigenetically silenced by methylation in several common tumours, thereby enhancing tumour proliferation and metastasis.
Jiabing, Wang, Tiantian, Ye, Shijian, Wang, Jinming, Wang, Yong, Jin   +4 more
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Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration

2022
SummaryMitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin (GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their roles in the central nervous system (CNS) are not well understood. Here, we find that one GSDM family member, GSDME is expressed by both mouse and human neurons.
Dylan V Neel, Himanish Basu, Georgia Gunner, Matthew D Bergstresser, Richard M. Giadone, Haeji Chung, Rui Miao, Vicky Chou, Eliza M. Brody, Xin Jiang, Edward B. Lee, Christine Marques, Aaron Held, Brian Wainger, Clotilde Lagier-Tourenne, Yong-Jie Zhang, Leonard Petrucelli, Tracy L. Young-Pearse, Alice S Chen-Plotkin, Lee L. Rubin, Judy Lieberman, Isaac M Chiu   +21 more
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Enhanced Gasdermin-E-mediated Pyroptosis in Alzheimer’s Disease

Neuroscience
Amyloid β protein (Aβ) is a critical factor in the pathogenesis of Alzheimer's disease (AD). Aβ induces apoptosis, and gasdermin-E (GSDME) expression can switch apoptosis to pyroptosis. In this study, we demonstrated that GSDME was highly expressed in the hippocampus of APP23/PS45 mouse models compared to that in age-matched wild-type mice.
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song   +8 more
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Role of Gasdermin E in the Biogenesis of Apoptotic Cell–Derived Exosomes

The Journal of Immunology, 2023
Abstract The gasdermins are a family of pore-forming proteins that has recently been suggested to play a central role in pyroptosis. In this study, we describe the novel roles of gasdermins in the biogenesis of apoptotic cell–derived exosomes.
Jaehark Hur, Yeon Ji Kim, Da Ae Choi, Dae Wook Kang, Jaeyoung Kim, Hyo Soon Yoo, Sk Abrar Shahriyar, Tamanna Mustajab, Junho Kim, Kyu Ri Han, Yujin Han, Sorim Lee, Dajung Song, Moriasi Sheba Kwamboka, Dong Young Kim, Yong-Joon Chwae   +15 more
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Improved antitumor immunity of chemotherapy in OSCC treatment by Gasdermin-E mediated pyroptosis

Apoptosis, 2022
Oral squamous cell carcinoma (OSCC) is a malignant tumor with high mortality and poor prognosis. Many OSCC patients have low response rate to current treatments including immunotherapies largely due to the immune-suppressive tumor microenvironment (TME). Chemotherapy could induce immunogenic cell death (ICD), a type of cell death such as pyroptosis and
Mei Zi, Chen Xingyu, Chen Yang, Su Xiaodong, Lv Shixian, Wei Shicheng   +5 more
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Abstract B58: Gasdermin E suppresses tumor growth by activating antitumor immunity

Cancer Immunology Research, 2020
Abstract The gasdermins (GSDM) are a family of homologous pore-forming proteins that cause pyroptosis, an inflammatory death associated with loss of cell membrane integrity and release of inflammatory mediators. Gasdermin E (GSDME, also known as DFNA5) as the most ancient member of the GSDM family has been implicated as a tumor ...
Zhibin Zhang, Ying Zhang, Shiyu Xia, Qing Kong, Shunying Li, Xing Liu, Caroline Junqueira, James Ansara, Satyaki Sengupta, Yandan Yao, Hao Wu, Judy Lieberman   +11 more
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Abstract A022: Gasdermin E suppresses tumor growth by activating antitumor immunity

Molecular Cancer Therapeutics, 2019
Abstract Caspase-3 cleaves gasdermin E (GSDME) and converts noninflammatory apoptosis to inflammatory cell death (pyroptosis) in GSDME-expressing cells. GSDME expression is suppressed in many cancer lines and mutated in some others, and reduced GSDME is associated with metastasis and decreased survival in breast cancer, suggesting GSDME ...
Zhibin Zhang, Ying Zhang, Shiyu Xia, Qing Kong, Shunying Li, Xing Liu, Caroline Junqueira, James Ansara, Satyaki Sengupta, Yandan Yao, Hao Wu, Judy Lieberman   +11 more
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