Results 61 to 70 of about 15,677 (174)

Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome

Cell Reports, 2018
Summary: The non-canonical caspase-4 and canonical NLRP3 inflammasomes are both activated by intracellular lipopolysaccharide (LPS), but the crosstalk between these two pathways remains unclear.
Jaye M. Platnich, Hyunjae Chung, Arthur Lau, Christina F. Sandall, Adom Bondzi-Simpson, Huey-Miin Chen, Takanori Komada, Aaron C. Trotman-Grant, Jeremy R. Brandelli, Justin Chun, Paul L. Beck, Dana J. Philpott, Stephen E. Girardin, May Ho, Roger P. Johnson, Justin A. MacDonald, Glen D. Armstrong, Daniel A. Muruve   +17 more
doaj   +1 more source

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death [PDF]

, 2016
Pyroptosis is a lytic type of cell death that is initiated by inflammatory caspases. These caspases are activated within multi-protein inflammasome complexes that assemble in response to pathogens and endogenous danger signals.
Broz, Petr, Farady, Christopher J., Heilig, Rosalie, Hiller, Sebastian, Mulvihill, Estefania, Müller, Daniel J., Pipercevic, Joka, Rühl, Sebastian, Sborgi, Lorenzo, Stahlberg, Henning   +9 more
core   +1 more source

Gasdermin E-derived caspase-3 inhibitors effectively protect mice from acute hepatic failure [PDF]

Acta Pharmacologica Sinica, 2020
Programmed cell death (PCD), including apoptosis, apoptotic necrosis, and pyroptosis, is involved in various organ dysfunction syndromes. Recent studies have revealed that a substrate of caspase-3, gasdermin E (GSDME), functions as an effector for pyroptosis; however, few inhibitors have been reported to prevent pyroptosis mediated by GSDME.
Wan-Feng, Xu, Quan, Zhang, Chu-Jie, Ding, Hui-Yong, Sun, Yuan, Che, Hai, Huang, Yun, Wang, Jia-Wei, Wu, Hai-Ping, Hao, Li-Juan, Cao   +9 more
openaire   +2 more sources

Pyroptosis: a double-edged sword in lung cancer and other respiratory diseases

Cell Communication and Signaling
Pyroptosis is an active cell death process mediated by gasdermin family proteins including Gasdermin A (GSDMA), Gasdermin B (GSDMB), Gasdermin C (GSDMC), Gasdermin D (GSDMD), Gasdermin E (GSDME, DFNA5), and DFNB59.
Xiao Liang, Ya Qin, Dan Wu, Qiong Wang, Hongshuai Wu   +4 more
doaj   +1 more source

Инфламмасомы и пироптоз эпителиальных клеток кишечника: вклад в развитие болезни Крона и неспецифического язвенного колита [PDF]

, 2019
ИНФЛАММАСОМЫПИРОПТОЗКЛЕТКИ СМЕРТЬЭПИТЕЛИОЦИТЫЭПИТЕЛИАЛЬНЫЕ КЛЕТКИКИШЕЧНИКА ВОСПАЛИТЕЛЬНЫЕ БОЛЕЗНИКРОНА БОЛЕЗНЬИЛЕИТ РЕГИОНАЛЬНЫЙИЛЕИТ ТЕРМИНАЛЬНЫЙИЛЕОКОЛИТЭНТЕРИТ ГРАНУЛОМАТОЗНЫЙКОЛИТ ЯЗВЕННЫЙПРОКТОКОЛИТ ЯЗВЕННЫЙПРОКТОЛИТ ГЕМОРРАГИЧЕСКИЙРЕКТОКОЛИТ ...
Ткаченко, А. С.
core   +1 more source

Compound loss of GSDMD and GSDME function is necessary to achieve maximal therapeutic effect in colitis

Journal of Translational Autoimmunity, 2022
Gasdermin D (GSDMD) and gasdermin E (GSDME) perpetuate inflammation by mediating the release of cytokines such as interleukin-1β (IL-1β) and IL-18. However, not only are the actions of GSDMD in colitis still controversial, but its interplay with GSDME in
Jianqiu Xiao, Kai Sun, Chun Wang, Yousef Abu-Amer, Gabriel Mbalaviele   +4 more
doaj   +1 more source

Gasdermin-Mediated Pyroptosis in Hidradenitis Suppurativa: Molecular Insights and Therapeutic Implications

Biology
Hidradenitis suppurativa (HS) is a debilitating inflammatory skin condition with unclear underlying mechanisms. Recent studies suggest pyroptosis, a highly inflammatory form of programmed cell death, could significantly contribute to the disease process.
Kinga Tyczyńska, Piotr K. Krajewski, Aleksandra Sójka, Danuta Nowicka-Suszko, Iwona Bednarz-Misa, Mariusz Fleszar, Małgorzata Krzystek-Korpacka, Jacek C. Szepietowski   +7 more
doaj   +1 more source

Gasdermins in Apoptosis: New players in an Old Game. [PDF]

, 2019
Apoptosis is a form of programmed cell death (PCD) that plays critical physiological roles in removing superfluous or dangerous cell populations that are unneeded or threatening to the health of the host organism.
Alnemri, Emad S., Rogers, Corey
core   +1 more source

Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death [PDF]

, 2016
Sensing bacterial products in the cytosol of mammalian cells by NOD-like receptors leads to the activation of caspase-1 inflammasomes, and the production of the pro-inflammatory cytokines interleukin (IL)-18 and IL-1β.
Alix, E, Birrell, M, Holden, D, Jennings, E, Matthews, S, Shao, F, Shenoy, A, Thurston, T   +7 more
core   +1 more source

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation [PDF]

, 2020
Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1.
De Munck, Jolien, de Reuver, Richard, Declercq, Wim, Devos, Michael, Dierick, Evelien, Gilbert, Barbara, Lefebvre, Sylvie, Maelfait, Jonathan, Nemegeer, Josephine, Rehwinkel, Jan, Tanghe, Giel, Vandenabeele, Peter, Verheirstraeten, Maud   +12 more
core   +2 more sources