GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms [PDF]
Blood Cancer Journal, 2022 Neoplasms originating from thymic T-cell progenitors and post-thymic mature T-cell subsets account for a minority of lymphoproliferative neoplasms. These T-cell derived neoplasms, while molecularly and genetically heterogeneous, exploit transcription ...
Xiangrong Geng +35 more
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GATA-3 expression in breast cancer is related to intratumoral M2 macrophage infiltration and tumor differentiation [PDF]
PLoS ONE, 2023 Accumulating evidence indicates that tumor-associated macrophages promote tumor progression and that high macrophage infiltration is correlated with advanced tumor stages and poor prognosis in breast cancer.
Husam Oda +3 more
doaj +5 more sources
Long non‐coding RNA MALAT1 promotes Th2 differentiation by regulating microRNA‐135b‐5p/GATA‐3 axis in children with allergic rhinitis [PDF]
Kaohsiung Journal of Medical Sciences, 2022 Allergic rhinitis (AR) threatens patient survival. CD4+ T cells play key roles in AR progression. Long non‐coding RNAs (lncRNAs) are key regulators of cell differentiation.
Xiong‐Hui Wu +5 more
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GATA-3 in T-cell lymphoproliferative disorders. [PDF]
IUBMB Life, 2020 AbstractGATA‐3 regulates the differentiation, proliferation, survival, and function of peripheral T cells and their thymic progenitors. Recent findings, reviewed here, not only implicate GATA‐3 in the pathogenesis of molecularly, genetically, and clinically distinct T‐cell lymphoproliferative disorders, but also have significant diagnostic, prognostic,
Murga-Zamalloa C, Wilcox RA.
europepmc +6 more sources
Effects of crocin on T-bet/GATA-3 ratio, and miR-146a and miR-106a expression levels in lung tissue of ovalbumin-sensitized mice [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Although various studies have revealed the beneficial effects of crocin (derived from saffron), such as anti-inflammatory, anti-cancer, antioxidant, and immune modulator, however, its exact mechanism is unknown.
Mohammad Reza Aslani +5 more
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Cryptotympana pustulata Extract and Its Main Active Component, Oleic Acid, Inhibit Ovalbumin-Induced Allergic Airway Inflammation through Inhibition of Th2/GATA-3 and Interleukin-17/RORγt Signaling Pathways in Asthmatic Mice [PDF]
Molecules, 2021 Cicadae Periostracum (CP), derived from the slough of Cryptotympana pustulata, has been used as traditional medicine in Korea and China because of its diaphoretic, antipyretic, anti-inflammatory, antioxidant, and antianaphylactic activities.
Seung-Hyung Kim +5 more
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Interaction between ANXA1 and GATA-3 in Immunosuppression of CD4+ T Cells [PDF]
Mediators of Inflammation, 2016 Decreased Th1/Th2 ratio is one of the major characteristics of immunosuppression in sepsis. Both membrane adhesive protein Annexin-A1 (ANXA1) and transcription factor GATA-3 have been reported to play important roles in T cell differentiation.
Peng Huang +3 more
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Expression of T-Bet, Eomesodermin, and GATA-3 Correlates With Distinct Phenotypes and Functional Properties in Porcine γδ T Cells [PDF]
Frontiers in Immunology, 2019 Unlike mice and humans, porcine γδ T cells represent a prominent subset of T cells in blood and secondary lymphatic organs. GATA-3, T-bet and Eomesodermin (Eomes) are transcription factors with crucial functions in T-cell development and functional ...
Irene M. Rodríguez-Gómez +13 more
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GATA‐3 expression in primary pure choriocarcinoma of the bladder [PDF]
IJU Case Reports, 2020 Introduction Primary pure choriocarcinoma of the bladder is extremely rare and should be distinguished from urothelial carcinoma. GATA‐3 is a zinc finger transcription factor and a known sensitive immunostaining marker for urothelial carcinoma.
Mayuka Shinohara +3 more
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The Role of Polymorphisms at the Interleukin-1, Interleukin-4, GATA-3 and Cyclooxygenase-2 Genes in Non-Surgical Periodontal Therapy. [PDF]
Int J Mol Sci, 2022 Periodontitis is a multifactorial disease. The aim of this explorative study was to investigate the role of Interleukin-(IL)-1, IL-4, GATA-3 and Cyclooxygenase-(COX)-2 polymorphisms after non-surgical periodontal therapy with adjunctive systemic ...
Walther KA +11 more
europepmc +2 more sources