Results 11 to 20 of about 18,813,060 (218)

GATA-3 dose-dependent checkpoints in early T cell commitment. [PDF]

J Immunol, 2014
Abstract GATA-3 expression is crucial for T cell development and peaks during commitment to the T cell lineage, midway through the CD4−CD8− (double-negative [DN]) stages 1–3. We used RNA interference and conditional deletion to reduce GATA-3 protein acutely at specific points during T cell differentiation in vitro.
Scripture-Adams DD, Damle SS, Li L, Elihu KJ, Qin S, Arias AM, Butler RR, Champhekar A, Zhang JA, Rothenberg EV.   +9 more
europepmc   +9 more sources

GATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumors [PDF]

Frontiers in Veterinary Science, 2023
IntroductionThe transcription factor GATA-3 plays a significant role in mammary gland development and differentiation. Recent studies on human oncology have demonstrated its association with favorable pathologic factors in breast cancer.
Gabriel Saraiva Diniz-Gonçalves, Anna Hielm-Björkman, Vanessa Bonfim da Silva, Lorena Gabriela Rocha Ribeiro, Carlos Humberto da Costa Vieira-Filho, Laís Pereira Silva, Stella Maria Barrouin-Melo, Stella Maria Barrouin-Melo, Geovanni Dantas Cassali, Karine Araújo Damasceno, Alessandra Estrela-Lima, Alessandra Estrela-Lima, Alessandra Estrela-Lima   +12 more
doaj   +2 more sources

Targeted Inhibition of GATA-3 by Pyrrothiogatain: Implications for Adipocyte Biology and Inflammatory Response [PDF]

Cells
GATA-3 is a master regulator of preadipocyte differentiation and function. Pharmacological or genetic targeting of GATA-3 will allow us to understand the function of GATA-3 in regulating metabolism, insulin signaling, and inflammation. Pyrrothiogatain, a
Shamma Almuraikhy, Maha Alser, Khaled Naja, Aisha Al-Malki, Nayef A. Mazloum, Mohamed A. Elrayess   +5 more
doaj   +2 more sources

CDK9 is a dependency in GATA-3 driven and MCL-1 independent T-cell Lymphomas [PDF]

Blood Cancer Journal
The transcription factor GATA-binding protein 3 (GATA-3) regulates oncogenic transcriptional programs across diverse T-cell lymphomas, including subsets of both peripheral and primary cutaneous T-cell lymphomas.
Chenguang Wang, Suhaib Abdelrahman, Xiangrong Geng, Alyssa Burgess, Ying S. Hu, Mohd Ahmar Rauf, Nermin Kady, Yao Fu, Tara A. Reilly, Ira P. Maine, Phillip Boonstra, Kirill Sabitov, Carlos Murga-Zamalloa, Ryan A. Wilcox   +13 more
doaj   +2 more sources

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

Cell, 1997
CD4 T cells potentiate the inflammatory or humoral immune response through the action of Th1 and Th2 cells, respectively. The molecular basis of the differentiation of these cells from naive T cell precursors is, however, unclear.
Wei-ping Zheng, R. Flavell
exaly   +2 more sources

Regulation of GATA-3 Expression during CD4 Lineage Differentiation [PDF]

The Journal of Immunology, 2011
Abstract GATA-3 is necessary for the development of MHC class II-restricted CD4 T cells, and its expression is increased during positive selection of these cells. TCR signals drive this upregulation, but the signaling pathways that control this process are not well understood.
Gimferer, Idoia, Hu, Taishan, Simmons, Amie, Wang, Chi, Souabni, Abdallah, Busslinger, Meinrad, Bender, Timothy P., Hernandez-Hoyos, Gabriela, Alberola-Ila, José   +8 more
openaire   +6 more sources

Caveolin-1, GATA-3, and Ki67 expressions and their correlation with pathological findings in canine bladder urothelial carcinoma [PDF]

Frontiers in Veterinary Science, 2022
The bladder urothelial carcinoma (UC) represents ~2% of malignant neoplasms in dogs and is a therapeutic challenge in veterinary medicine. Although it is considered the most common bladder cancer in dogs, few previous studies have investigated different ...
Verônica Mollica Govoni, Claudio Pigoli, Eleonora Brambilla, Felipe Augusto Ruiz Sueiro, Rafael Torres Neto, Renee Laufer-Amorim, Juliany Gomes Quitzan, Valeria Grieco, Carlos Eduardo Fonseca-Alves, Carlos Eduardo Fonseca-Alves   +9 more
doaj   +2 more sources

Overexpression of T-bet, GATA-3 and TGF-ß Induces IFN-γ, IL-4/13A, and IL-17A Expression in Atlantic Salmon [PDF]

Biology, 2020
The overexpression of GATA-3, T-bet and TGF-ß may theoretically induce IL-4/A, IFN-γ and IL-17A expression, respectively. Whether this also applies to fish is not yet known.
Tiril H. Slettjord, Hege J. Sekkenes, Heng Chi, Jarl Bøgwald, Trilochan Swain, Roy A. Dalmo, Jaya Kumari Swain   +6 more
doaj   +2 more sources

Notch3 inhibits epithelial-mesenchymal transition in breast cancer via a novel mechanism, upregulation of GATA-3 expression. [PDF]

Oncogenesis, 2018
Notch3 and GATA binding protein 3 (GATA-3) have been, individually, shown to maintain luminal phenotype and inhibit epithelial–mesenchymal transition (EMT) in breast cancers.
Lin HY, Liang YK, Dou XW, Chen CF, Wei XL, Zeng, Bai JW, Guo YX, Lin FF, Huang WH, Du CW, Li YC, Chen M, Zhang GJ.   +13 more
europepmc   +2 more sources

Double cocktail immunostains with high molecular weight cytokeratin and GATA-3: useful stain to discriminate in situ involvement of prostatic ducts or acini from stromal invasion by urothelial carcinoma in the prostate [PDF]

Journal of Pathology and Translational Medicine, 2020
Background Distinguishing prostatic stromal invasion (PSI) by urothelial carcinoma (UC) from in situ UC involving prostatic ducts or acini with no stromal invasion (in situ involvement) may be challenging on hematoxylin and eosin stained sections ...
Junghye Lee, Youngeun Yoo, Sanghui Park, Min-Sun Cho, Sun Hee Sung, Jae Y. Ro   +5 more
doaj   +2 more sources