GATA-3 dose-dependent checkpoints in early T cell commitment. [PDF]
J Immunol, 2014 GATA-3 expression is crucial for T cell development and peaks during commitment to the T cell lineage, midway through the CD4CD8 (double-negative [DN]) stages 1–3.
Scripture-Adams DD +9 more
europepmc +8 more sources
GATA‐3 expression in primary pure choriocarcinoma of the bladder [PDF]
IJU Case Reports, 2020 Introduction Primary pure choriocarcinoma of the bladder is extremely rare and should be distinguished from urothelial carcinoma. GATA‐3 is a zinc finger transcription factor and a known sensitive immunostaining marker for urothelial carcinoma.
Mayuka Shinohara +3 more
doaj +5 more sources
Regulation of GATA-3 Expression during CD4 Lineage Differentiation [PDF]
The Journal of Immunology, 2011 GATA-3 is necessary for the development of MHC class II-restricted CD4 T cells, and its expression is increased during positive selection of these cells.
Alberola-Ila, José +8 more
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Interaction between ANXA1 and GATA-3 in Immunosuppression of CD4+ T Cells [PDF]
Mediators of Inflammation, 2016 Decreased Th1/Th2 ratio is one of the major characteristics of immunosuppression in sepsis. Both membrane adhesive protein Annexin-A1 (ANXA1) and transcription factor GATA-3 have been reported to play important roles in T cell differentiation.
Peng Huang +3 more
doaj +2 more sources
Double cocktail immunostains with high molecular weight cytokeratin and GATA-3: useful stain to discriminate in situ involvement of prostatic ducts or acini from stromal invasion by urothelial carcinoma in the prostate [PDF]
Journal of Pathology and Translational Medicine, 2020 Background Distinguishing prostatic stromal invasion (PSI) by urothelial carcinoma (UC) from in situ UC involving prostatic ducts or acini with no stromal invasion (in situ involvement) may be challenging on hematoxylin and eosin stained sections ...
Junghye Lee +5 more
doaj +2 more sources
GATA-3 Suppression by DNAzyme Modulates Interleukin-10 and Liver Injury Markers in db/db Mice [PDF]
BiologyObesity plays a crucial role in the progression of insulin resistance and type 2 diabetes which are related to inflammation and liver disease. GATA-3 is a transcription factor that is involved in adipogenesis and inflammation.
Layla Al-Mansoori +13 more
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Expression of T-Bet, Eomesodermin, and GATA-3 Correlates With Distinct Phenotypes and Functional Properties in Porcine γδ T Cells [PDF]
Frontiers in Immunology, 2019 Unlike mice and humans, porcine γδ T cells represent a prominent subset of T cells in blood and secondary lymphatic organs. GATA-3, T-bet and Eomesodermin (Eomes) are transcription factors with crucial functions in T-cell development and functional ...
Irene M. Rodríguez-Gómez +13 more
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Embryonic expression and cloning of the murine GATA-3 gene. [PDF]
Development, 1994 We describe the embryonic expression pattern as well as the cloning and initial transcriptional regulatory analysis of the murine (m) GATA-3 gene. In situ hybridization shows that mGATA-3 mRNA accumulation is temporally and spatially regulated during ...
Engel, J.D. (Douglas) +6 more
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GATA-3 locks the door to the B-cell option [PDF]
Blood, 2013 T-cell early developmental stages and alternative options: GATA-3 is depicted as an intrathymically induced, specific inhibitor of access to the B-lineage pathway.
Rothenberg, Ellen V.
core +5 more sources
GATA-3 in T-cell lymphoproliferative disorders. [PDF]
IUBMB Life, 2020 AbstractGATA‐3 regulates the differentiation, proliferation, survival, and function of peripheral T cells and their thymic progenitors. Recent findings, reviewed here, not only implicate GATA‐3 in the pathogenesis of molecularly, genetically, and clinically distinct T‐cell lymphoproliferative disorders, but also have significant diagnostic, prognostic,
Murga-Zamalloa C, Wilcox RA.
europepmc +5 more sources