Results 21 to 30 of about 54,955 (220)

Mammary like gland adenoma with GATA-3 expression - a benign vulval tumor with mammary differentiation often misdiagnosed as adenocarcinoma [PDF]

New Indian Journal of OBGYN, 2021
Papillary hidradenoma/ mammary-like gland adenoma (MLGA) is a benign glandular tumor of the vulva. It presents as a mass lesion which often undergoes secondary ulceration and bleeding resembling a malignant tumor.
Deval Parekh, Sunaina Wadhwa, Asima Mukhopadhyay, Angad Singh   +3 more
doaj   +1 more source

Gata-3 and mammary cell fate [PDF]

Breast Cancer Research, 2007
Genomic regulatory networks specify how cellular gene expression responds to external temporal and spatial stimuli, ensuring that correct cell fate decisions are made and the appropriate cell phenotypes are adopted. In mammary epithelial cells, the hierarchy of stem and progenitor cells and the genetically specified program of transcriptional activity ...
Naylor, Matthew J, Ormandy, Christopher J   +1 more
openaire   +2 more sources

Transactivation of human osteoprotegerin promoter by GATA-3. [PDF]

Sci Rep, 2015
AbstractOsteoprotegerin (OPG) is a key regulator of bone remodeling. Mutations in OPG are involved in a variety of human diseases. We have shown that cochlear spiral ganglion cells secrete OPG at high levels and lack of OPG causes sensorineural hearing loss in addition to the previously described conductive hearing loss.
Kao SY, Stankovic KM.
europepmc   +5 more sources

Can GATA3 Immunocytochemistry be Utilized as a Reliable Diagnostic Marker for Metastatic Breast Carcinoma in Cytological Materials? A Comparative Study with Mammaglobin and GCDFP-15 Expression [PDF]

Türk Patoloji Dergisi, 2018
Objective: Cytomorphologic differentiation of metastatic breast carcinoma from non breast metastases in cytological materials can be difficult. Current breast immunocytochemical markers have low sensitivities.
Nesreen H. HAFEZ, HebatAllah M. SHAABAN
doaj   +1 more source

GATA-3 Function in Innate and Adaptive Immunity [PDF]

Immunity, 2014
The zinc-finger transcription factor GATA-3 has received much attention as a master regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4), IL-5, and IL-13 expression. More recently, GATA-3 was shown to contribute to type 2 immunity through regulation of group 2 innate lymphoid cell (ILC2) development and ...
Tindemans, Irma, Serafini, Nicolas, Di Santo, James P, Hendriks, Rudi W   +3 more
openaire   +3 more sources

GATA‐binding protein 3 and gross cystic disease fluid protein 15 as a potential diagnostic marker for extramammary Paget's disease

Journal of Cutaneous Immunology and Allergy, 2021
Objectives The aim of this study was to evaluate the expression of GCDFP15 and GATA‐binding protein 3 (GATA‐3) in extramammary Paget's disease (EMPD) skin and serum samples and to assess their availability as tumor markers for the diagnosis and ...
Soichiro Kado, Koji Kamiya, Meijuan Jin, Miho Kimura, Md Razib Hossain, Takeo Maekawa, Mayumi Komine, Mamitaro Ohtsuki   +7 more
doaj   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice [PDF]

, 2001
The zinc finger transcription factor GATA-3 is of critical importance for early T cell development and commitment of Th2 cells.
Dingjan, G.M. (Gemma), Drabek, D.D. (Dubravka), Ferreira, R. (Rita), Grosveld, F.G. (Frank), Hendriks, R.W. (Rudi), Kahre, O., Karis, A. (Alar), Nawijn, M.C. (Martijn)   +7 more
core   +7 more sources

Aberrant Gata-3 Expression in Human Pancreatic Cancer [PDF]

Journal of Histochemistry & Cytochemistry, 2006
Gata-3 has been shown to specifically alter its expression patterns in different types of cancers. Recent evidence suggests that an interference of Gata-3 exists in the TGF-β signaling pathway. To determine the role of Gata-3 in pancreatic cancer, pancreatic cancer samples were analyzed in comparison to normal pancreatic tissues.
Antanas, Gulbinas, Pascal O, Berberat, Zilvinas, Dambrauskas, Thomas, Giese, Nathalia, Giese, Frank, Autschbach, Joerg, Kleeff, Stefan, Meuer, Markus W, Büchler, Helmut, Friess   +9 more
openaire   +2 more sources

Human Female Genital Tract Infection by the Obligate Intracellular Bacterium Chlamydia trachomatis Elicits Robust Type 2 Immunity [PDF]

, 2013
While Chlamydia trachomatis infections are frequently asymptomatic, mechanisms that regulate host response to this intracellular Gram-negative bacterium remain undefined.
AL Graham, AN Barclay, B Pulendran, BJ Wilson, C Cobaleda, C Soo, C Van Themsche, CR Cohen, Dean B. Matthews, FO Martinez, G Schaefer, G Tanaka, J Turner, JE Allen, JE Allen, JF Peipert, Jörn Coers, M Busslinger, M Molano, M Stein, M Wang, MJ Jardim, RC Brunham, RD Vicetti Miguel, RD Vicetti Miguel, RD Vicetti Miguel, RD Vicetti Miguel, RJ Snelgrove, RM Anthony, RM Hoek, Rodolfo D. Vicetti Miguel, S Fichtner-Feigl, S Fichtner-Feigl, S Fujisaka, Seth D. Reighard, Stephen A. K. Harvey, T Darville, Thomas L. Cherpes, V Hebbar, VH Hu, W Conca, William A. LaFramboise, WM Geisler   +42 more
core   +8 more sources