A MULTI-OMICS REVIEW OF GATA-3
Journal of Student ResearchBreast cancer is a prevalent mutation-caused disease that affects millions of people worldwide. One such gene that is related to causing the cancer is GATA3. This gene is a regulator of t-cell development and is also involved with causing luminal breast cancer when altered.
Yashas Revanakara
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Embryonic expression and cloning of the murine GATA-3 gene [PDF]
Development, 1994 ABSTRACT We describe the embryonic expression pattern as well as the cloning and initial transcriptional regulatory analysis of the murine (m) GATA-3 gene. In situ hybridization shows that mGATA-3 mRNA accumulation is temporally and spatially regulated during early development: although found most abundantly in the placenta prior to 10 ...
K M, George +6 more
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Participation of GATA-3 in regulation of bone healing through transcriptional upregulation of bcl-xL expression. [PDF]
Exp Mol Med, 2017 We have previously demonstrated the expression of GATA-DNA-binding protein (GATA)-3, a transcription factor, in osteoblasts and have verified its function in transducing cell survival signaling.
Liao MH +5 more
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Transactivation of human osteoprotegerin promoter by GATA-3. [PDF]
Sci Rep, 2015 AbstractOsteoprotegerin (OPG) is a key regulator of bone remodeling. Mutations in OPG are involved in a variety of human diseases. We have shown that cochlear spiral ganglion cells secrete OPG at high levels and lack of OPG causes sensorineural hearing loss in addition to the previously described conductive hearing loss.
Kao SY, Stankovic KM.
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Intranasal Administration of Lentiviral miR-135a Regulates Mast Cell and Allergen-Induced Inflammation by Targeting GATA-3. [PDF]
PLoS ONE, 2015 Mast cell (MC) degranulation is the foundation of the acute phase of allergic rhinitis (AR). Previously, downregulation of GATA binding protein 3 (GATA-3) was shown to suppress MC activation in an AR mouse model.
Yu-Qin Deng +6 more
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Palmitate inhibits arthritis by inducing t-bet and gata-3 mRNA degradation in iNKT cells via IRE1α-dependent decay. [PDF]
Sci Rep, 2017 Long chain fatty acids (LCFAs) exert pro-inflammatory effects in vivo. However, little is known regarding the effect of LCFAs on invariant (i) NKT cell functions.
Ko JS +5 more
europepmc +2 more sources
Clinical significance of T-bet, GATA-3, and Bcl-6 transcription factor expression in bladder carcinoma [PDF]
Journal of Translational Medicine, 2016 BackgroundThe aim of this study was to investigate the clinical significance of three immune cell-related transcription factors, T-bet, GATA-3 and Bcl-6 in bladder cancer in Tunisian patients.MethodsExpression of T-bet, GATA-3 and Bcl-6 genes was ...
Islem Ben Bahria-Sediki +7 more
semanticscholar +4 more sources
Transcription Factors Oct-1 and GATA-3 Cooperatively Regulate Th2 Cytokine Gene Expression via the RHS5 within the Th2 Locus Control Region. [PDF]
PLoS ONE, 2016 The T helper type 2 (Th2) locus control region (LCR) regulates Th2 cell differentiation. Several transcription factors bind to the LCR to modulate the expression of Th2 cytokine genes, but the molecular mechanisms behind Th2 cytokine gene regulation are ...
Kiwan Kim, Najung Kim, Gap Ryol Lee
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GATA-3 Suppression by DNAzyme Modulates Interleukin-10 and Liver Injury Markers in db/db Mice [PDF]
BiologyObesity plays a crucial role in the progression of insulin resistance and type 2 diabetes which are related to inflammation and liver disease. GATA-3 is a transcription factor that is involved in adipogenesis and inflammation.
Layla Al-Mansoori +13 more
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Different Expressions of Specific Transcription Factors of Th1 (T-bet) and Th2 cells (GATA-3) by Peripheral Blood Mononuclear Cells From Patients With Multiple Sclerosis. [PDF]
Basic Clin Neurosci, 2018 Introduction: Multiple Sclerosis (MS) is an inflammatory disorder caused by self-reactive Th1 lymphocytes, while Th2 cells may confer protection. The Th1 and Th2 cell differentiation are regulated by specific transcription factors, especially T-bet and ...
Etesam Z +6 more
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