Results 41 to 50 of about 54,955 (220)
PLoS Medicine, 2009 BackgroundGATA-3 plays a critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing
Kittipong Maneechotesuwan +6 more
doaj +1 more source
Immunohistoochemical evaluation of GATA-3, pAKT and Ki-67 in triple negative breast carcinoma
Journal of Pathology of Nepal, 2017 Background: Triple-negative breast cancers lack expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor -2. These tumors have been known to be clinically aggressive. We evaluate GATA-3, pAKT and Ki-67 expression
Gopi Aryal +5 more
doaj +1 more source
Embryonic expression of the human GATA-3 gene
Mechanisms of Development, 1999 The spatial and temporal analysis of GATA-3 expression pattern in the human embryo revealed its expression in new anatomical sites. These include the endoderm of the primitive foregut, pharynx and allantois, the branchial arches and the mesenchymal cells surrounding the stomach and dorsal aorta.
Debacker, Cécile +2 more
openaire +2 more sources
FoxP3, GATA‐3 and T‐bet expression in elderly asthma [PDF]
Clinical & Experimental Allergy, 2010 Cite this as: S. Vale‐Pereira, A. Todo‐Bom, L. Geraldes, C. Schmidt‐Weber, C. A. Akdis and A. Mota‐Pinto, Clinical & Experimental Allergy, 2011 (41) 490–496.SummaryBackground Asthma is a chronic inflammatory disorder in which Th2, Th1 and suppressive T cells (Tregs) play a role.
Vale-Pereira, S +5 more
openaire +5 more sources
PLoS ONE, 2013 We previously reported that IL-3 signaling induces phosphorylation of GATA-1 at the serine²⁶ position, which contributes to IL-3-mediated anti-apoptotic response. Here, we demonstrate that phosphorylation of GATA-1 at serine²⁶ is also transiently induced
Kou-Ray Lin +3 more
doaj +1 more source
GATA-3-dependent Gene Transcription is Impaired upon HDAC Inhibition. [PDF]
Clin Cancer ResAbstract Purpose: Many peripheral and cutaneous T-cell lymphoma (CTCL) subtypes are poorly responsive to conventional chemotherapeutic agents and associated with dismal outcomes. The zinc finger transcription factor GATA-3 and the transcriptional program it instigates are oncogenic and highly ...
Geng X +9 more
europepmc +3 more sources
IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo [PDF]
, 2013 IL-6 plays a pivotal role in favoring T-cell commitment toward a Th17 cell rather than Treg-cell phenotype, as established through in vitro model systems.
Maizels, Rick M, Smith, Katherine A
core +2 more sources
Forging T-Lymphocyte Identity: Intersecting Networks of Transcriptional Control [PDF]
, 2016 T-lymphocyte development branches off from other lymphoid developmental programs through its requirement for sustained environmental signals through the Notch pathway.
Champhekar, Ameya +2 more
core +1 more source
A Novel Non-invasive Method to Detect RELM Beta Transcript in Gut Barrier Related Changes During a Gastrointestinal Nematode Infection [PDF]
, 2019 Currently, methods for monitoring changes of gut barrier integrity and the associated immune response via non-invasive means are limited. Therefore, we aimed to develop a novel non-invasive technique to investigate immunological host responses ...
Affinass, Nicole +8 more
core +4 more sources
Indian Journal of Medical and Paediatric Oncology, 2020 Choriocarcinoma can occur at ectopic extragenital locations such as lungs, mediastinum, retroperitoneum, and even in the brain (nongestational choriocarcinoma).
Rahul Mannan +3 more
doaj +1 more source