Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice [PDF]
, 2001 The zinc finger transcription factor GATA-3 is of critical importance for early T cell development and commitment of Th2 cells.
Dingjan, G.M. (Gemma) +7 more
core +7 more sources
Aberrant Gata-3 Expression in Human Pancreatic Cancer [PDF]
Journal of Histochemistry & Cytochemistry, 2006 Gata-3 has been shown to specifically alter its expression patterns in different types of cancers. Recent evidence suggests that an interference of Gata-3 exists in the TGF-β signaling pathway. To determine the role of Gata-3 in pancreatic cancer, pancreatic cancer samples were analyzed in comparison to normal pancreatic tissues.
Antanas, Gulbinas +9 more
openaire +2 more sources
Cellular Signalling, 2020 Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes. Adipose tissue inflammation is a crucial mediator of this process.
Layla Al-mansoori +7 more
semanticscholar +1 more source
A gene regulatory network armature for T lymphocyte specification [PDF]
, 2008 Choice of a T lymphoid fate by hematopoietic progenitor cells depends on sustained Notch–Delta signaling combined with tightly regulated activities of multiple transcription factors. To dissect the regulatory network connections that mediate this process,
Bolouri, Hamid +7 more
core +2 more sources
Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3 [PDF]
, 2007 GATA-3 is essential for T cell development from the earliest stages. However, abundant GATA-3 can drive T lineage precursors to a non–T cell fate, depending on Notch signaling and developmental stage.
B Heavey +52 more
core +2 more sources
Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours [PDF]
, 2009 Introduction: The expression of additional genes, other than oestrogen receptor (ER), may be important to the hormone-responsive phenotype of breast cancer. Microarray analyses have revealed that forkhead box A1 (FOXA1) and GATA binding protein 3 (GATA-3)
André Albergaria +49 more
core +5 more sources
GATA-3 Stimulates Proliferation of Endometriotic Cells
Ginekologia Polska, 2019 This study aimed to investigate whether there was a correlation between the expression of GATA binding protein 3 (GATA-3) and the proliferation of endometrium cells from women with endometriosis.Endometrial tissue was collected from 20 women with endometriosis (experimental group) and 10 women without endometriosis (control group).
Peng, Chen, Fang, Ren, Dan-Bo, Wang
openaire +3 more sources
GATA-3 EXPRESSION IN PERIPHERAL BLOOD LYMPHOCYTES OF PATIENTS WITH BRONCHIAL ASTHMA
Медицинская иммунология, 2014 The aim of the study is to establish the features of expression of GATA-3 in peripheral lymphocytes from bronchial asthma patients (BA). Material and methods.
V. N. Mineev +3 more
doaj +1 more source
Transcription factor GATA‐3 is essential for lens development [PDF]
Developmental Dynamics, 2009 AbstractDuring vertebrate lens development, the anterior, ectoderm‐derived lens vesicle cells differentiate into a monolayer of epithelial cells that retain proliferative potential. Subsequently, they exit the cell cycle and give rise to posterior lens fiber cells that form the lens body.
Maeda, Atsuko +9 more
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Expression of GATA‐3 During Lymphocyte Differentiation and Mouse Embryogenesis [PDF]
Journal of Immunology Research, 1992 The GATA family of C4 zinc‐finger transcription factors has been implicated in tissuespecific gene regulation in birds and mammals. One of the members of this family, GATA‐3, is reportedly expressed specifically in the T‐cell lineage, where it interacts with GATA motifs in the TCR‐αα, TCR‐β/, and TCR‐δ enhancers, thereby controlling the T‐cell ...
Oosterwegel, M.A. +3 more
openaire +3 more sources