Results 51 to 60 of about 54,955 (220)

Cutting Edge : Failure of Antigen-Specific CD4+ T Cell Recruitment to the Kidney during Systemic Candidiasis [PDF]

, 2014
Copyright © 2014 The Authors. Acknowledgments We thank E. Bolton and H. Bagavant for reagents and advice. We also acknowledge the staff of the Medical Research Facility at the University of Aberdeen for care of the animals used in this study.
Brown, Gordon D, Drummond, Rebecca A, Kaplan, Daniel H, Reid, Delyth M, Wallace, Carol, Way, Sing Sing   +5 more
core   +2 more sources

Striking Similarity: GATA-3 Regulates ILC2 and Th2 Cells [PDF]

Immunity, 2012
Innate lymphoid cells (ILCs) and T helper (Th) cells share similar effector functions. In this issue of Immunity, Hoyler et al. (2012) and Mjosberg et al. (2012) demonstrate that GATA-3, a Th2 regulator, controls ILC2 differentiation, maintenance, and function.
openaire   +2 more sources

Transcription Factors Oct-1 and GATA-3 Cooperatively Regulate Th2 Cytokine Gene Expression via the RHS5 within the Th2 Locus Control Region. [PDF]

PLoS ONE, 2016
The T helper type 2 (Th2) locus control region (LCR) regulates Th2 cell differentiation. Several transcription factors bind to the LCR to modulate the expression of Th2 cytokine genes, but the molecular mechanisms behind Th2 cytokine gene regulation are ...
Kiwan Kim, Najung Kim, Gap Ryol Lee
doaj   +1 more source

Identification, Characterization, and Expression Profiling of Maize GATA Gene Family in Response to Abiotic and Biotic Stresses

Agronomy, 2023
GATA transcription factor is crucial for plant growth and development, physiological metabolism, and environmental response, which has been reported in many plants.
Yuchao Hu, Jingyi Huang, Li Yu, Changjin Wang, Xinwei Zhang, Xinxin Cheng, Haibing Yu, Kaijing Zhang   +7 more
doaj   +1 more source

Critical Roles for Transcription Factor GATA-3 in Thymocyte Development [PDF]

Immunity, 2003
The transcription factor GATA-3 is expressed at every stage of thymic development, but its role in thymocyte differentiation is unknown. The fact that RAG chimeric animals lacking GATA-3 cannot generate early thymocytes from common lymphoid progenitors has thus far precluded investigation of the function of GATA-3 in the thymus.
Pai, Sung-Yun, Truitt, Morgan L, Ting, Chao-Nan, Leiden, Jeffrey M, Glimcher, Laurie H, Ho, I-Cheng   +5 more
openaire   +2 more sources

Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy [PDF]

, 2017
Immune checkpoint factors, such as programmed cell death protein-1/2 (PD-1, PD-2) or cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) receptors, are targets for monoclonal antibodies (MAbs) developed for cancer immunotherapy.
Mai, Antonello, Mazzone, Roberta, Valente, Sergio, Zwergel, Clemens   +3 more
core   +1 more source

Glucocorticoids—All-Rounders Tackling the Versatile Players of the Immune System [PDF]

, 2019
Glucocorticoids regulate fundamental processes of the human body and control cellular functions such as cell metabolism, growth, differentiation, and apoptosis.
Agarwal, Al-Mousawi, Allen, Almawi, Anderson, Andreae, Annunziato, Anthony, Arya, Avnir, Avnir, Baatjes, Banchereau, Banuelos, Banuelos, Barnes, Beck, Beck, Belvisi, Bengtsson, Benson, Bentley, Berdeli, Blotta, Borish, Brack, Bradding, Braun, Brozek, Burger, Buttgereit, Buttgereit, Buttgereit, Capell, Chan, Chatham, Chen, Choo, Chung, Clutterbuck, Cohn, Corbera-Bellalta, Cosmi, Cosmi, Crocker, Cronstein, Damsker, Dao Nguyen, Daynes, Daynes, de Castro Kroner, Deng, Dolhain, Dorner, Dougherty, Durham, Eichenauer, Eichhorst, Eklund, Erin, Espigol-Frigole, Fanouriakis, Finotto, Firestein, Firestein, Franchimont, Franchimont, Franco, Gao, Geginat, Gemou-Engesaeth, Gladman, Gomes, Gracie, Gregersen, Greiner, Grindebacke, Guiducci, Gupta, Hadji, Hagan, Hahn, Hamid, Hamid, Hanahan, Haneda, Hartl, Hasegawa, Hawrylowicz, Hehlmann, Heidari, Heiman, Hellmich, Hermann-Kunz, Hernandez-Rodriguez, Hicsonmez, Hirahara, Hoelzer, Hollenberg, Hu, Hussain, Hutchison, Inaba, Ismaili, Jacobi, Jacobi, Jee, Jennette, Jiang, Jin, Jing, John, Jones, Jones, Kansal, Kaplan, Karagiannidis, Kirwan, Klarenbeek, Klassen, Kleiman, Klein, Klimek, Kotake, Kotake, Kovalovsky, Kremer, Kruth, Leppert, Li, Li-Weber, Liberman, Liles, Lim, Lin, Linden, Liu, Loetscher, Lohse, Lugar, Luo, Machold, Maggi, Maneechotesuwan, Manzoni, Martinez-Sanchez, Maruotti, Matsui, Matteson, McDonough, Meagher, Mercieca, Merrill, Miller, Miltenburg, Mitra, Miyasaka, Miyaura, Moallem, Morita, Moynihan, Mozo, Muehling, Munck, Muraro, Murphy, Naseer, Neeck, Neeck, Nicholson, O'Byrne, O'Byrne, Oakley, Oakley, Ochiai, Odendahl, Oppong, Ospelt, Parrillo, Patel, Pawankar, Pearson, Perez-Guerrero, Pers, Picchianti-Diamanti, Pratt, Pratt, Pui, Qin, Quinn, Radich, Rainer, Rak, Ramirez, Rank, Ratman, Refojo, Reichardt, Rider, Ring, Robinson, Robinson, Ronnblom, Ruiz-Arruza, Saadoun, Sallusto, Samson, Samson, Santos, Schacke, Schacke, Scherlinger, Schmitz, Schug, Shah, Shaw, Shlomchik, Siegel, Smith, Smolen, Smolen, Song, Stahn, Stahn, Stellato, Stone, Strehl, Strehl, Tanaka, Terrades-Garcia, Theofilopoulos, Thomas, Thomas, Till, Tuckermann, Turjeman, Ulmansky, Umetsu, van der Geest, van Oosterhout, Vandevyver, Verhoef, Verstappen, von Bernus, von Hertzen, Waknine-Grinberg, Walker, Wang, Wassenberg, Watanabe, Wen, Weyand, Weyand, Wheatley, Wikstrom, Willemze, Wills-Karp, Wills-Karp, Wollenberg, Wollenberg, Wright, Wu, Wuthrich, Xystrakis, Yamamoto, Yan, Yang, Ying, Zubiaga   +268 more
core   +1 more source

GATA-3 in Human T Cell Helper Type 2 Development [PDF]

The Journal of Experimental Medicine, 2004
The delineation of the in vivo role of GATA-3 in human T cell differentiation is a critical step in the understanding of molecular mechanisms directing human immune responses. We examined T cell differentiation and T cell–mediated effector functions in individuals lacking one functional GATA-3 allele.
Skapenko, Alla, Leipe, Jan, Niesner, Uwe, Devriendt, Koen, Beetz, Rolf, Radbruch, Andreas, Kalden, Joachim R., Lipsky, Peter E., Schulze-Koops, Hendrik   +8 more
openaire   +2 more sources

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. [PDF]

PLoS ONE, 2011
Allergic asthma is associated with airway eosinophilia, which is regulated by different T-effector cells. T cells express transcription factors T-bet, GATA-3, RORγt and Foxp3, representing Th1, Th2, Th17 and Treg cells respectively. No study has directly
You Lu, Carina Malmhäll, Margareta Sjöstrand, Madeleine Rådinger, Serena E O'Neil, Jan Lötvall, Apostolos Bossios   +6 more
doaj   +1 more source