Results 51 to 60 of about 18,813,060 (218)

Down-regulated GATA-1 up-regulates interferon regulatory factor 3 in lung adenocarcinoma

Scientific Reports, 2017
Interferon regulatory factor 3 (IRF-3) is widely known for its prompt response against viral infection by activating the interferon system. We previously reported that E2F1, Sp1 and Sp3 regulated transcriptional activity of IRF-3.
Lu-Lu Wang, Zheng-Sen Chen, Wen-Di Zhou, Jin Shu, Xiao-Hua Wang, Rui Jin, Li-Li Zhuang, Mir Alireza Hoda, Hao Zhang, Guo-Ping Zhou   +9 more
doaj   +1 more source

Immunohistoochemical evaluation of GATA-3, pAKT and Ki-67 in triple negative breast carcinoma

Journal of Pathology of Nepal, 2017
Background: Triple-negative breast cancers lack expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor -2. These tumors have been known to be clinically aggressive. We evaluate GATA-3, pAKT and Ki-67 expression
Gopi Aryal, Sameer Chhetri Aryal, Yurie Soejima, Victoria Sheckler, Yoshinobu Eishi, Motoji Sawabe   +5 more
doaj   +1 more source

Embryonic expression of the human GATA-3 gene

Mechanisms of Development, 1999
The spatial and temporal analysis of GATA-3 expression pattern in the human embryo revealed its expression in new anatomical sites. These include the endoderm of the primitive foregut, pharynx and allantois, the branchial arches and the mesenchymal cells surrounding the stomach and dorsal aorta.
Debacker, Cécile, Catala, Martin, Labastie, Marie-Claude   +2 more
openaire   +2 more sources

FoxP3, GATA‐3 and T‐bet expression in elderly asthma [PDF]

Clinical & Experimental Allergy, 2010
Cite this as: S. Vale‐Pereira, A. Todo‐Bom, L. Geraldes, C. Schmidt‐Weber, C. A. Akdis and A. Mota‐Pinto, Clinical & Experimental Allergy, 2011 (41) 490–496.SummaryBackground Asthma is a chronic inflammatory disorder in which Th2, Th1 and suppressive T cells (Tregs) play a role.
Vale-Pereira, S, Todo-Bom, A, Geraldes, L, Schmidt-Weber, Carsten, Akdis, C A, Mota-Pinto, A   +5 more
openaire   +5 more sources

Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease.

PLoS Medicine, 2009
BackgroundGATA-3 plays a critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing
Kittipong Maneechotesuwan, Xin Yao, Kazuhiro Ito, Elen Jazrawi, Omar S Usmani, Ian M Adcock, Peter J Barnes   +6 more
doaj   +1 more source

Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 Cells [PDF]

, 2017
Infections by the soil-transmitted threadworm Strongyloides stercoralis affect 50-100 million people worldwide, predominantly in tropic and sub-tropic regions. Here we assessed the T helper cell phenotypes in threadworm-infected patients and experimental
Afkarian, Allen, Anthony, Anuradha, Bisoffi, Blankenhaus, Breloer, Buonfrate, Cai, Chang, Chiuso-Minicucci, Dawkins, Erbe, Eschbach, Figueiredo, Finkelman, Finkelman, Guo, Guo, Harris, Hegazy, Helmstetter, Ioan-Facsinay, Jenner, Kim, Lohning, Montes, Nouir, Ouyang, Pai, Panzer, Patel, Peine, Pesce, Puthiyakunnon, Quinnell, Rausch, Robinson, Ruano, Ruano, Siddiqui, Snapper, Steinfelder, Strandmark, Szabo, Turner, Turner, Urban, Vadlamudi, Vidarsson, Weatherhead, Yoshimoto, Zheng, Zhu, Zhu   +54 more
core   +3 more sources

Inhibition of kras-derived exosomes downregulates immunosuppressive BACH2/GATA-3 expression via RIP-3 dependent necroptosis and miR-146/miR-210 modulation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019
Immunosuppressive chemoresistance is a major challenge in lung cancer treatment. Exosomes present in the tumor microenviroment are implicated in chemoresistant-related immune suppression, and metastasis but the exact pathogenic role of lung-derived ...
Savvas Petanidis, K. Domvri, Konstantinos Porpodis, D. Anestakis, L. Freitag, W. Hohenforst-Schmidt, D. Tsavlis, K. Zarogoulidis   +7 more
semanticscholar   +1 more source

Human Female Genital Tract Infection by the Obligate Intracellular Bacterium Chlamydia trachomatis Elicits Robust Type 2 Immunity [PDF]

, 2013
While Chlamydia trachomatis infections are frequently asymptomatic, mechanisms that regulate host response to this intracellular Gram-negative bacterium remain undefined.
AL Graham, AN Barclay, B Pulendran, BJ Wilson, C Cobaleda, C Soo, C Van Themsche, CR Cohen, Dean B. Matthews, FO Martinez, G Schaefer, G Tanaka, J Turner, JE Allen, JE Allen, JF Peipert, Jörn Coers, M Busslinger, M Molano, M Stein, M Wang, MJ Jardim, RC Brunham, RD Vicetti Miguel, RD Vicetti Miguel, RD Vicetti Miguel, RD Vicetti Miguel, RJ Snelgrove, RM Anthony, RM Hoek, Rodolfo D. Vicetti Miguel, S Fichtner-Feigl, S Fichtner-Feigl, S Fujisaka, Seth D. Reighard, Stephen A. K. Harvey, T Darville, Thomas L. Cherpes, V Hebbar, VH Hu, W Conca, William A. LaFramboise, WM Geisler   +42 more
core   +3 more sources

Constitutive phosphorylation of GATA-1 at serine²⁶ attenuates the colony-forming activity of erythrocyte-committed progenitors.

PLoS ONE, 2013
We previously reported that IL-3 signaling induces phosphorylation of GATA-1 at the serine²⁶ position, which contributes to IL-3-mediated anti-apoptotic response. Here, we demonstrate that phosphorylation of GATA-1 at serine²⁶ is also transiently induced
Kou-Ray Lin, Chung-Leung Li, Jeffrey Jong-Young Yen, Hsin-Fang Yang-Yen   +3 more
doaj   +1 more source

IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo [PDF]

, 2013
IL-6 plays a pivotal role in favoring T-cell commitment toward a Th17 cell rather than Treg-cell phenotype, as established through in vitro model systems.
Maizels, Rick M, Smith, Katherine A
core   +2 more sources