Results 41 to 50 of about 21,925 (161)

PU.1 Suppresses Th2 Cytokine Expression via Silencing of GATA3 Transcription in Dendritic Cells.

PLoS ONE, 2015
The transcription factor PU.1 is predominantly expressed in dendritic cells (DCs) and is essential for DC differentiation. Although there are several reports that PU.1 positively regulates the expression of DC-specific genes, whether PU.1 also has a ...
Takuya Yashiro, Masato Kubo, Hideoki Ogawa, Ko Okumura, Chiharu Nishiyama   +4 more
doaj   +1 more source

GATA3 expression is decreased in psoriasis and during epidermal regeneration; induction by narrow-band UVB and IL-4.

PLoS ONE, 2011
Psoriasis is characterized by hyperproliferation of keratinocytes and by infiltration of activated Th1 and Th17 cells in the (epi)dermis. By expression microarray, we previously found the GATA3 transcription factor significantly downregulated in lesional
Emoke Rácz, Dorota Kurek, Marius Kant, Ewout M Baerveldt, Edwin Florencia, Sabine Mourits, Dick de Ridder, Jon D Laman, Leslie van der Fits, Errol P Prens   +9 more
doaj   +1 more source

Transcriptomic analysis and novel insights into lens fibre cell differentiation regulated by Gata3 [PDF]

Open Biology, 2019
Gata3 is a DNA-binding transcription factor involved in cellular differentiation in a variety of tissues including inner ear, hair follicle, kidney, mammary gland and T-cells. In a previous study in 2009, Maeda et al. (Dev. Dyn.
Elena Martynova, Yilin Zhao, Qing Xie, Deyou Zheng, Ales Cvekl   +4 more
doaj   +1 more source

Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2 [PDF]

Journal of Clinical Investigation, 2010
Heterozygous mutations of GATA3, which encodes a dual zinc-finger transcription factor, cause hypoparathyroidism with sensorineural deafness and renal dysplasia. Here, we have investigated the role of GATA3 in parathyroid function by challenging Gata3+/- mice with a diet low in calcium and vitamin D so as to expose any defects in parathyroid function ...
Grigorieva, Irina V., Mirczuk, Samantha, Gaynor, Katherine U., Nesbit, M. Andrew, Grigorieva, Elena F., Wei, Qiaozhi, Ali, Asif, Fairclough, Rebecca J., Stacey, Joanna M., Stechman, Michael J., Mihai, Radu, Kurek, Dorota, Fraser, WD, Hough, Tertius, Condie, Brian G., Manley, Nancy, Grosveld, Frank, Thakker, Rajesh V.   +17 more
openaire   +4 more sources

Brca1 Is Regulated by the Transcription Factor Gata3, and Its Silencing Promotes Neural Differentiation in Retinal Neurons

International Journal of Molecular Sciences, 2022
Previous studies have indicated that Brca1 (Breast cancer suppressor gene 1) plays an important role in neural development and degenerative diseases. However, the bioactivity and regulatory mechanism of Brca1 expression in retinal neurocytes remain unclear.
Jiejie Zhuang, Pei Chen, Yihui Wu, Qian Luo, Qiyun Wang, Shuilian Chen, Xi Chen, Zihua Jiang, Jin Qiu, Yan Li, Zhaohui Yuan, Jing Zhuang   +11 more
openaire   +2 more sources

GATA3 induces the pathogenicity of Th17 cells via regulating GM-CSF expression

Frontiers in Immunology, 2023
T-bet-expressing Th17 (T-bet+RORγt+) cells are associated with the induction of pathology during experimental autoimmune encephalomyelitis (EAE) and the encephalitic nature of these Th17 cells can be explained by their ability to produce GM-CSF. However,
Matthew J. Butcher, Rama Krishna Gurram, Xiaoliang Zhu, Xi Chen, Gangqing Hu, Gangqing Hu, Vanja Lazarevic, Keji Zhao, Jinfang Zhu   +8 more
doaj   +1 more source

Transcriptional co-regulator OCA-B/Pou2af1 restricts Th2 differentiation

Frontiers in Immunology
BackgroundType 2 immunity is initiated through a synergistic response between innate and adaptive immune cells to facilitate host-pathogen defense and wound repair, yet aberrant responses can contribute to chronic inflammation and allergic disease.
Erik P. Hughes, Erik P. Hughes, Asit K. Manna, Asit K. Manna, Wenxiang Sun, Sandra M. Osburn-Staker, Samuel Aamodt, Kristi J. Warren, James E. Cox, Dean Tantin, Dean Tantin   +10 more
doaj   +1 more source

Regulatory T‐lymphocytes mediate amyotrophic lateral sclerosis progression and survival

EMBO Molecular Medicine, 2012
In amyotrophic lateral sclerosis (ALS) mice, regulatory T‐lymphocytes (Tregs) are neuroprotective, slowing disease progression. To address whether Tregs and FoxP3, a transcription factor required for Treg function, similarly influence progression rates ...
Jenny S. Henkel, David R. Beers, Shixiang Wen, Andreana L. Rivera, Karen M. Toennis, Joan E. Appel, Weihua Zhao, Dan H. Moore, Suzanne Z. Powell, Stanley H. Appel   +9 more
doaj   +1 more source

GATA3 Positively Correlates with BCL2 Expression in Indolent and Aggressive Histological Types of Cutaneous Basal Cell Carcinoma [PDF]

Türk Patoloji Dergisi
Objective: Some histological basal cell carcinoma (BCC) types demonstrate more aggressive behavior than others. They are known as high-risk BCC and are more challenging in therapy, contrary to indolent (low-risk) BCC types.
Fatma Alzahraa Abdelsalam ELKHAMISY, Ahmed Naeem EESA, Marwa Kamal SALLAM, Marwa Fathy HUSSEIN, Nadia Ahmed ABD EL-MOEZE   +4 more
doaj   +1 more source

Hearing loss following Gata3 haploinsufficiency is caused by cochlear disorder

Neurobiology of Disease, 2004
Patients with HDR syndrome suffer from hypoparathyroidism, deafness, and renal dysplasia due to a heterozygous deletion of the transcription factor GATA3.
Jacqueline van der Wees, Marjolein A.J van Looij, M.Martijn de Ruiter, Helineth Elias, Hans van der Burg, Su-San Liem, Dorota Kurek, J.Doug Engel, Alar Karis, Bert G.A van Zanten, Chris I De Zeeuw, Frank G Grosveld, J.Hikke van Doorninck   +12 more
doaj   +1 more source