Results 1 to 10 of about 8,130,594 (350)

Modulators of gene amplification alter evolution of antibiotic resistance in Staphylococcus aureus. [PDF]

PLoS Genetics
Gene amplification is thought to be common in bacterial populations, providing a rapid and reversible mode of adaptation to diverse stresses, including the acquisition of antibiotic resistance.
Kalinga Pavan T Silva, Anthony M Martini, Anupama Khare   +2 more
doaj   +2 more sources

Gene Amplification in Tumor Cells: Developed De Novo or Adopted from Stem Cells [PDF]

Cells, 2022
Gene amplifications have been known for several decades as physiological processes in amphibian and flies, e.g., during eggshell development in Drosophila and as part of pathological processes in humans, specifically in tumors and drug-resistant cells ...
Ulrike Fischer, Eckart Meese
doaj   +2 more sources

Developmentally Programmed Switches in DNA Replication: Gene Amplification and Genome-Wide Endoreplication in Tetrahymena [PDF]

Microorganisms, 2023
Locus-specific gene amplification and genome-wide endoreplication generate the elevated copy number of ribosomal DNA (rDNA, 9000 C) and non-rDNA (90 C) chromosomes in the developing macronucleus of Tetrahymena thermophila.
Xiangzhou Meng, Hung Quang Dang, Geoffrey M. Kapler   +2 more
doaj   +2 more sources

Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification [PDF]

Cell Genomics
Summary: Recent work by the ICGC-PCAWG consortium identified recurrent focal deletions in the BRD4 gene, decreasing expression despite increased copy number.
Jeremiah Wala, Simona Dalin, Sophie Webster, Ofer Shapira, John Busanovich, Shahab Sarmashghi, Rameen Beroukhim, Pratiti Bandopadhayay, Veronica Rendo   +8 more
doaj   +2 more sources

Uterine leiomyosarcomas harboring MAP2K4 gene amplification are sensitive in vivo to PLX8725, a novel MAP2K4 inhibitor. [PDF]

Gynecol Oncol, 2023
McNamara B, Harold J, Manavella D, Bellone S, Mutlu L, Hartwich TMP, Zipponi M, Yang-Hartwich Y, Demirkiran C, Verzosa MSZ, Yang K, Choi J, Dong W, Buza N, Hui P, Altwerger G, Huang GS, Andikyan V, Clark M, Ratner E, Azodi M, Schwartz PE, Burton EA, Inagaki H, Albers A, Zhang C, Bollag G, Schlessinger J, Santin AD.   +28 more
europepmc   +3 more sources

Targeting FGFR in non-small cell lung cancer: implications from the landscape of clinically actionable aberrations of FGFR kinases

Cancer Biology & Medicine, 2021
Objective: Dysfunction in fibroblast growth factor receptor (FGFR) signaling has been reported in diverse cancer types, including non-small cell lung cancer (NSCLC).
Zhen Zhou, Zichuan Liu, Qiuxiang Ou, Xue Wu, Xiaonan Wang, Yang Shao, Hongyan Liu, Yu Yang   +7 more
doaj   +1 more source

A rare epidermal growth factor receptor (EGFR) gene mutation in small cell lung carcinoma patients

Biomedical Papers, 2022
Aim. Activating mutations in the epidermal growth factor receptor (EGFR) are predominantly detected in pulmonary adenocarcinoma and have been reported in small cell lung cancer (SCLC) for decades. This retrospective single-center study aimed to determine
Cheng-Cheng Hwang, Tsan-Yu Hsieh, Kun-Yang Yeh, Tzu-Ping Chen, Chung-Ching Hua, Liang-Che Chang, Jim-Ray Chen   +6 more
doaj   +1 more source

A Temporary Pause in the Replication Licensing Restriction Leads to Rereplication during Early Human Cell Differentiation

Cells, 2022
Gene amplifications in amphibians and flies are known to occur during development and have been well characterized, unlike in mammalian cells, where they are predominantly investigated as an attribute of tumors.
Marie Minet, Masood Abu-Halima, Yiqing Du, Julia Doerr, Christina Isted, Nicole Ludwig, Andreas Keller, Eckart Meese, Ulrike Fischer   +8 more
doaj   +1 more source

IS26 Veers Genomic Plasticity and Genetic Rearrangement toward Carbapenem Hyperresistance under Sublethal Antibiotics

mBio, 2022
Multidrug-resistant Gram-negative carriers of Klebsiella pneumoniae carbapenemases (KPCs) often subvert antibiotic therapy due to inadequate sensitivity in laboratory detection.
Da-Wei Wei, Nai-Kei Wong, Yuqin Song, Gang Zhang, Chao Wang, Juan Li, Jie Feng   +6 more
doaj   +1 more source

Chromothripsis drives the evolution of gene amplification in cancer

Nature, 2020
Focal chromosomal amplification contributes to the initiation of cancer by mediating overexpression of oncogenes1–3, and to the development of cancer therapy resistance by increasing the expression of genes whose action diminishes the efficacy of anti ...
Ofer Shoshani, Simon F. Brunner, R. Yaeger, P. Ly, Yael Nechemia-Arbely, D. H. Kim, Rongxin Fang, Guillaume A. Castillon, Miao Yu, Julia S Z Li, Ying Sun, Mark Ellisman, B. Ren, P. Campbell, D. Cleveland   +14 more
semanticscholar   +1 more source