Results 1 to 10 of about 7,578,155 (258)
Gene amplification in carcinogenesis [PDF]
Genetics and Molecular Biology, 2006 Gene amplification increases the number of genes in a genome and can give rise to karyotype abnormalities called double minutes (DM) and homogeneously staining regions (HSR), both of which have been widely observed in human tumors but are also known to ...
Lucimari Bizari +2 more
doaj +6 more sources
Gene Amplification in Tumor Cells: Developed De Novo or Adopted from Stem Cells [PDF]
Cells, 2022 Gene amplifications have been known for several decades as physiological processes in amphibian and flies, e.g., during eggshell development in Drosophila and as part of pathological processes in humans, specifically in tumors and drug-resistant cells ...
Ulrike Fischer, Eckart Meese
doaj +2 more sources
Developmentally Programmed Switches in DNA Replication: Gene Amplification and Genome-Wide Endoreplication in Tetrahymena [PDF]
Microorganisms, 2023 Locus-specific gene amplification and genome-wide endoreplication generate the elevated copy number of ribosomal DNA (rDNA, 9000 C) and non-rDNA (90 C) chromosomes in the developing macronucleus of Tetrahymena thermophila.
Xiangzhou Meng +2 more
doaj +2 more sources
Mechanisms of Gene Duplication and Amplification [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 Changes in gene copy number are among the most frequent mutational events in all genomes and were among the mutations for which a physical basis was first known. Yet mechanisms of gene duplication remain uncertain because formation rates are difficult to measure and mechanisms may vary with position in a genome.
Reams, Andrew B, Roth, John R
openaire +6 more sources
Gene amplification in Rhynchosciara (1955-1987) [PDF]
Memorias do Instituto Oswaldo Cruz, 1987 A review is made of the evidence indicating the existence of gene amplification in Rhynchosciara, from the early cytological work to the more recent studies using cloned sequences from the DNA puffs.
Francisco J. S. Lara
doaj +5 more sources
Cancer Biology & Medicine, 2021 Objective: Dysfunction in fibroblast growth factor receptor (FGFR) signaling has been reported in diverse cancer types, including non-small cell lung cancer (NSCLC).
Zhen Zhou +7 more
doaj +1 more source
mBio, 2022 Multidrug-resistant Gram-negative carriers of Klebsiella pneumoniae carbapenemases (KPCs) often subvert antibiotic therapy due to inadequate sensitivity in laboratory detection.
Da-Wei Wei +6 more
doaj +1 more source
Chromothripsis drives the evolution of gene amplification in cancer
Nature, 2020 Focal chromosomal amplification contributes to the initiation of cancer by mediating overexpression of oncogenes1–3, and to the development of cancer therapy resistance by increasing the expression of genes whose action diminishes the efficacy of anti ...
Ofer Shoshani +14 more
semanticscholar +1 more source
Microbiology Spectrum, 2021 The activation of unrecognized antibiotic resistance genes in the bacterial cell can give rise to antibiotic resistance without the need for major mutations or horizontal gene transfer.
Stacy A. Suarez, Adam C. Martiny
doaj +1 more source
Selective gene amplification [PDF]
Protein Engineering Design and Selection, 2007 We describe a system for directed evolution based on in vitro compartmentalisation in which amplification of a gene is coupled to the formation of product by the enzyme it encodes. This approach mimics the process of natural selection; 'fitter' genes--encoding more efficient enzymes--have more 'offspring'.
Bernard T, Kelly, Andrew D, Griffiths
openaire +2 more sources