Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification [PDF]
Genome Biology, 2015 BackgroundHER2 is overexpressed and amplified in approximately 15% of invasive breast cancers, and is the molecular target and predictive marker of response to anti-HER2 agents.
C. Ng +22 more
semanticscholar +4 more sources
Fluorescence in situ hybridization analysis of the hTERC region in acute myeloid leukemia patients [PDF]
Turkish Journal of Hematology, 2011 OBJECTIVE: The telomerase RNA component (hTERC) gene is located at 3q26. Increased hTERC gene expression has been frequently observed and amplification was shown using fluorescence in situ hybridization (FISH) in different cancers.
Özge Özer +3 more
doaj +3 more sources
Investigation of c-Myc gene amplification in breast cancer patients and its correlation with other prognostic factors [PDF]
Fiyz̤, 2018 Background: Breast cancer is the most common cancer in woman. The frequency of amplification of some proto-oncogenes like c-Myc gene may be various in different populations.
Zohreh Zahraei +2 more
doaj +2 more sources
A randomized, open-label study of the efficacy and safety of AZD4547 monotherapy versus paclitaxel for the treatment of advanced gastric adenocarcinoma with FGFR2 polysomy or gene amplification [PDF]
Annals of Oncology, 2017 Background:Approximately 5%-10% of gastric cancers have a fibroblast growth factor receptor-2 (FGFR2) gene amplification. AZD4547 is a selective FGFR-1, 2, 3 tyrosine kinase inhibitor with potent preclinical activity in FGFR2 amplified gastric ...
E. Cutsem +12 more
semanticscholar +7 more sources
Definitions, 2020 Gene amplification is an increase in the number of copies of a gene sequence. Cancer cells sometimes produce multiple copies of genes in response to signals from other cells or their environment. The term also can refer to polymerase chain reaction (PCR),
semanticscholar +1 more source
A rare epidermal growth factor receptor (EGFR) gene mutation in small cell lung carcinoma patients
Biomedical Papers, 2022 Aim. Activating mutations in the epidermal growth factor receptor (EGFR) are predominantly detected in pulmonary adenocarcinoma and have been reported in small cell lung cancer (SCLC) for decades. This retrospective single-center study aimed to determine
Cheng-Cheng Hwang +6 more
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Genome position and gene amplification [PDF]
Genome Biology, 2007 Abstract Background Amplifications, regions of focal high-level copy number change, lead to overexpression of oncogenes or drug resistance genes in tumors. Their presence is often associated with poor prognosis; however, the use of amplification as a mechanism for overexpression of a particular gene in ...
Daniel Pinkel +7 more
openaire +3 more sources
Cells, 2022 Gene amplifications in amphibians and flies are known to occur during development and have been well characterized, unlike in mammalian cells, where they are predominantly investigated as an attribute of tumors.
Marie Minet +8 more
doaj +1 more source
Sex determining region Y-box 2 (SOX2) amplification is an independent indicator of disease recurrence in sinonasal cancer. [PDF]
, 2013 The transcription factor SOX2 (3q26.3-q27) is an embryonic stem cell factor contributing to the induction of pluripotency in terminally differentiated somatic cells.
Agaimy, Abbas +14 more
core +7 more sources
Prevalence of human papillomavirus infection of 65,613 women in East China
BMC Public Health, 2019 Background The infection with human papillomavirus (HPV) is the major cause of genital disease. This study assessed the prevalence and genotype of HPV among outpatient women and healthy women in Jiangsu, East China.
Yanmei Ge +5 more
doaj +1 more source