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Definitions, 2020 Gene amplification is an increase in the number of copies of a gene sequence. Cancer cells sometimes produce multiple copies of genes in response to signals from other cells or their environment. The term also can refer to polymerase chain reaction (PCR),
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Selective gene amplification [PDF]
Protein Engineering Design and Selection, 2007 We describe a system for directed evolution based on in vitro compartmentalisation in which amplification of a gene is coupled to the formation of product by the enzyme it encodes. This approach mimics the process of natural selection; 'fitter' genes--encoding more efficient enzymes--have more 'offspring'.
Bernard T, Kelly, Andrew D, Griffiths
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Microbiology Spectrum, 2021 The activation of unrecognized antibiotic resistance genes in the bacterial cell can give rise to antibiotic resistance without the need for major mutations or horizontal gene transfer.
Stacy A. Suarez, Adam C. Martiny
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Prevalence of human papillomavirus infection of 65,613 women in East China
BMC Public Health, 2019 Background The infection with human papillomavirus (HPV) is the major cause of genital disease. This study assessed the prevalence and genotype of HPV among outpatient women and healthy women in Jiangsu, East China.
Yanmei Ge +5 more
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Gene amplification in carcinogenesis
Genetics and Molecular Biology, 2006 Gene amplification increases the number of genes in a genome and can give rise to karyotype abnormalities called double minutes (DM) and homogeneously staining regions (HSR), both of which have been widely observed in human tumors but are also known to ...
Lucimari Bizari +2 more
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