Results 21 to 30 of about 8,130,594 (350)

circRNA meets gene amplification [PDF]

Non-coding RNA Investigation, 2018
Lung cancer remains the most common cause of cancer related death among both males and females globally accounting for 1.69 million deaths in 2015 (1). Of the different types of lung cancer, lung adenocarcinoma (LAC) is the most common (2). Given the prevalence and lethality of lung cancer the need to elucidate the mechanisms of this disease and to ...
Nicholas, Manguso, Armando E, Giuliano, Hisashi, Tanaka   +2 more
openaire   +2 more sources

The Prognostic Value and Overexpression of Cyclin A Is Correlated with Gene Amplification of both Cyclin A and Cyclin E in Breast Cancer Patient

Cellular Oncology, 2006
Deregulation of cell cycle control is a hallmark of cancer. The primary cyclins (A, B1, D1, D3 and E) are crucial for cell cycle progression. Secondary cyclins (C and H) have putative indirect effects on cell cycle propulsion and are not previously ...
A. Husdal, G. Bukholm, I. R. K. Bukholm
doaj   +1 more source

Expression of Bcl-2 protein and the amplification of c-myc gene in patients with chronic myeloid leukemia [PDF]

Vojnosanitetski Pregled, 2006
Background/Aim. Chronic myeloid leukemia (CML) represents a malignant myeloproliferative disease developed out of pluripotent hematopoietic stem cell that contains the fusion bcr-abl gene. Disorders that occur in the process of apoptosis represent one of
Strnad Milica, Brajušković Goran, Strelić Nataša, Živanović-Todorić Biljana, Tukić Ljiljana, Stamatović Dragana   +5 more
doaj   +1 more source

Amplification of the Chromosomal blaCTX-M-14 Gene in Escherichia coli Expanding the Spectrum of Resistance under Antimicrobial Pressure

Microbiology Spectrum, 2022
Various forms of adaptive evolution occur in clinical isolates in response to the presence of antimicrobial drugs. Among a total of 171 CTX-M-9 group/family extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli blood isolates recovered ...
Eun-Jeong Yoon, You Jeong Choi, Dokyun Kim, Dongju Won, Jong Rak Choi, Seok Hoon Jeong   +5 more
doaj   +1 more source

The association between fibroblast growth factor receptor 1 gene amplification and lung cancer: a meta-analysis

Archives of Medical Science, 2019
Introduction Identifying target oncogenic alterations in lung cancer represents a major development in disease management. We examined the association of fibroblast growth factor receptor 1 (FGFR1) gene amplification with pathological characteristics and
Jian-Long Miao, Jin-Hua Zhou, Jing-Jing Cai, Rui-Juan Liu   +3 more
doaj   +1 more source

CD274/PD-L1 gene amplification and PD-L1 protein expression are common events in squamous cell carcinoma of the oral cavity

OncoTarget, 2016
Immunomodulatory therapies, targeting the immune checkpoint receptor-ligand complex PD-1/PD-L1 have shown promising results in early phase clinical trials in solid malignancies, including carcinomas of the head and neck.
M. Straub, E. Drecoll, N. Pfarr, W. Weichert, R. Langer, A. Hapfelmeier, C. Götz, K. Wolff, A. Kolk, K. Specht   +9 more
semanticscholar   +1 more source

Analysis of DNA Polymerases Reveals Specific Genes Expansion in Leishmania and Trypanosoma spp.

Frontiers in Cellular and Infection Microbiology, 2020
Leishmaniasis and trypanosomiasis are largely neglected diseases prevailing in tropical and subtropical conditions. These are an arthropod-borne zoonosis that affects humans and some animals and is caused by infection with protozoan of the genera ...
Ana Poveda, Ana Poveda, Miguel Ángel Méndez, Vinicio Armijos-Jaramillo   +3 more
doaj   +1 more source

Correlation Between C-MYC, BCL-2, and BCL-6 Protein Expression and Gene Translocation as Biomarkers in Diagnosis and Prognosis of Diffuse Large B-cell Lymphoma

Frontiers in Pharmacology, 2019
This study investigates the protein expression of C-MYC, BCL-2, and BCL-6 in diffuse large B-cell lymphoma (DLBCL) and their relationship with genetic abnormalities.
YunXiang Zhang, Hui Wang, Cuiai Ren, Hai Yu, Wenjia Fang, Na Zhang, Sumei Gao, Qian Hou   +7 more
doaj   +1 more source

Loop mediated isothermal amplification: An innovative gene amplification technique for animal diseases

Veterinary World, 2016
India being a developing country mainly depends on livestock sector for its economy. However, nowadays, there is emergence and reemergence of more transboundary animal diseases.
P. R. Sahoo, Kamadev Sethy, S. Mohapatra, Debasis Panda   +3 more
semanticscholar   +1 more source

LYL1 gene amplification predicts poor survival of patients with uterine corpus endometrial carcinoma: analysis of the Cancer genome atlas data

BMC Cancer, 2018
Background Somatic amplifications of the LYL1 gene are relatively common occurrences in patients who develop uterine corpus endometrial carcinoma (UCEC) as opposed to other cancers.
Se Ik Kim, Ji Won Lee, Nara Lee, Maria Lee, Hee Seung Kim, Hyun Hoon Chung, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song, Jeong-Sun Seo   +9 more
doaj   +1 more source