Results 21 to 30 of about 8,013,600 (393)
The prognostic impact of EGFR, ErbB2 and MET gene amplification in human gastric carcinomas as measured by quantitative Real-Time PCR [PDF]
, 2015 Purpose: Identification of critical genes which play pivotal roles in controlling tumor growth and survival will establish the basis for developing therapeutic targets. In this study, we focused on frequencies of EGFR, ErbB2 and MET gene amplification in
Farazmandfar, T. +4 more
core +1 more source
Topoisomerase expression and amplification in solid tumours: Analysis of 24,262 patients. [PDF]
, 2017 BackgroundTopoisomerase I (TOPO1) and topoisomerase IIα (TOP2A) are specific targets of multiple chemotherapy drugs. Increased expression of TOPO1 protein and amplification of the TOP2A gene have been associated with treatment response in colorectal and ...
Arguello, David +4 more
core +1 more source
Microbiology Spectrum, 2022 Enhanced levels of resistance to antibiotics arising from amplification of an antibiotic resistance gene that impact therapeutic options are increasingly observed. Amplification can also disclose novel phenotypes leading to treatment failure.
Christopher J. Harmer +4 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 1988 We have devised a simple and efficient cDNA cloning strategy that overcomes many of the difficulties encountered in obtaining full-length cDNA clones of low-abundance mRNAs.
M. Frohman, M. Dush, G. Martin
semanticscholar +1 more source
Amplification of the androgen receptor may not explain the development of androgen-independent prostate cancer [PDF]
, 2001 Objective To examine the role of androgen receptor (AR) gene amplification and aneusomy of the X chromosome in the development of antiandrogen-resistant prostate cancer.
Bartlett, J.M.S. +5 more
core +1 more source
ON THE ROLE OF RNA IN GENE AMPLIFICATION [PDF]
Acta Endocrinologica, 1972 ABSTRACT A complex of ribosomal DNA with RNA has been isolated from ovaries of metamorphosing tadpoles of Xenopus laevis. The complex is disrupted by treatments which destroy hydrogen bonds and the sedimentation of the DNA within the complex is sensitive to RNase.
E Mattoccia +2 more
openaire +6 more sources
MYCN gene amplification in rhabdomyosarcoma [PDF]
Cancer, 1994 Amplification of the MYCN oncogene, formerly known as N-myc, has been seen in several malignant tumors, particularly neuroblastoma, where its association with a poor clinical outcome is the clearest example of a clinically relevant oncogene mutation in any human cancer.The incidence and clinical significance of MYCN amplification in rhabdomyosarcoma ...
Paul S. Thorner +4 more
openaire +3 more sources
Phosphorylation of pRb: mechanism for RB pathway inactivation in MYCN-amplified retinoblastoma. [PDF]
, 2017 A small, but unique subgroup of retinoblastoma has been identified with no detectable mutation in the retinoblastoma gene (RB1) and with high levels of MYCN gene amplification.
Bhatti, Tricia R. +6 more
core +2 more sources
BMC Cancer, 2018 Background Somatic amplifications of the LYL1 gene are relatively common occurrences in patients who develop uterine corpus endometrial carcinoma (UCEC) as opposed to other cancers.
Se Ik Kim +9 more
doaj +1 more source
The role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa [PDF]
, 2007 Objective Artemether-lumefantrine (AL), presently the most favoured combination therapy against uncomplicated Plasmodium falciparum malaria in Africa, has recently shown to select for the pfmdr1 86N allele.
Barnes +21 more
core +2 more sources