Results 31 to 40 of about 8,130,594 (350)

Clinical and imaging features of a pedigree with spinocerebellar ataxia type 6

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
doi：10.3969/j.issn.1672⁃6731.2021.06 ...
YANG Yun⁃peng, LIU Jia , WANG Lu⁃ning   +2 more
doaj   +1 more source

HER2 (++) Amplification in Breast Cancer Detected by Fluorescence in Situ Hybridization and Its Correlation with Clinicopathological Features

Zhongliu Fangzhi Yanjiu, 2018
Objective To detect the amplification of HER2 gene by fluorescence in situ hybridization(FISH), and explore the correlation between HER2 gene amplification and clinicopathological characteristics. Methods We collected 325 cases of breast cancer with HER2(
ZHANG Mingshuai, WANG Zhou, JIANG Weihua, LI Yongtao, FULATI·Wuwalihan, OU Jianghua   +5 more
doaj   +1 more source

Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification

Genome Biology, 2015
BackgroundHER2 is overexpressed and amplified in approximately 15% of invasive breast cancers, and is the molecular target and predictive marker of response to anti-HER2 agents.
C. Ng, L. Martelotto, A. Gauthier, H. Wen, S. Piscuoglio, R. Lim, C. Cowell, P. Wilkerson, Patty T. Wai, D. Rodrigues, L. Arnould, F. Geyer, S. Bromberg, M. Lacroix-Triki, F. Penault-Llorca, S. Giard, X. Sastre-Garau, R. Natrajan, L. Norton, P. Cottu, B. Weigelt, A. Vincent‐Salomon, J. Reis-Filho   +22 more
semanticscholar   +1 more source

Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways

Microbial Cell, 2019
Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These assays have been developed in microbial systems that provide the advantages of genetic and molecular reporters that can readily be ...
Hannah L. Klein, Giedrė Bačinskaja, Jun Che, Anais Cheblal, Rajula Elango, Anastasiya Epshtein, Devon M. Fitzgerald, Belén Gómez-González, Sharik R. Khan, Sandeep Kumar, Bryan A. Leland, Léa Marie, Qian Mei, Judith Miné-Hattab, Alicja Piotrowska, Erica J. Polleys, Christopher D. Putnam, Elina A. Radchenko, Anissia Ait Saada, Cynthia J. Sakofsky, Eun Yong Shim, Mathew Stracy, Jun Xia, Zhenxin Yan, Yi Yin, Andrés Aguilera, Juan Lucas Argueso, Catherine H. Freudenreich, Susan M. Gasser, Dmitry A. Gordenin, James E. Haber, Grzegorz Ira, Sue Jinks-Robertson, Megan C. King, Richard D. Kolodner, Andrei Kuzminov, Sarah AE Lambert, Sang Eun Lee, Kyle M. Miller, Sergei M. Mirkin, Thomas D. Petes, Susan M. Rosenberg, Rodney Rothstein, Lorraine S. Symington, Pawel Zawadzki, Nayun Kim, Michael Lisby, Anna Malkova   +47 more
doaj   +1 more source

Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis

Oncogene, 2015
The introduction of new therapies against particular genetic mutations in non-small-cell lung cancer is a promising avenue for improving patient survival, but the target population is small.
C. Anadón, S. Guil, L. Simó-Riudalbas, C. Moutinho, F. Setién, A. Martínez-Cardús, S. Moran, A. Villanueva, M. Calaf, A. Vidal, P. Lazo, I. Zondervan, S. Savola, T. Kohno, J. Yokota, L. R. de Pouplana, M. Esteller   +16 more
semanticscholar   +1 more source

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Viral load could be an important determinant for fomites based transmission of viral infections

Journal of Family Medicine and Primary Care, 2021
Background and Objective: Fomites are common sources of transmission of certain infections. Infectious pathogens, such as viruses known to cause respiratory tract infections, are common examples of being transmitted by fomites.
Dhirendra P Singh, Mahesh C Sahu, Avinash Pagdhune, Ankit Viramgami, Sivaperumal Perumal, Rakesh Balachandar, Kamalesh Sarkar   +6 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source