Results 31 to 40 of about 7,371,567 (249)
MYCN gene amplification in rhabdomyosarcoma [PDF]
Cancer, 1994 Amplification of the MYCN oncogene, formerly known as N-myc, has been seen in several malignant tumors, particularly neuroblastoma, where its association with a poor clinical outcome is the clearest example of a clinically relevant oncogene mutation in any human cancer.The incidence and clinical significance of MYCN amplification in rhabdomyosarcoma ...
Paul S. Thorner +4 more
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Cellular Oncology, 2006 Deregulation of cell cycle control is a hallmark of cancer. The primary cyclins (A, B1, D1, D3 and E) are crucial for cell cycle progression. Secondary cyclins (C and H) have putative indirect effects on cell cycle propulsion and are not previously ...
A. Husdal, G. Bukholm, I. R. K. Bukholm
doaj +1 more source
A rare epidermal growth factor receptor (EGFR) gene mutation in small cell lung carcinoma patients
Biomedical Papers, 2022 Aim. Activating mutations in the epidermal growth factor receptor (EGFR) are predominantly detected in pulmonary adenocarcinoma and have been reported in small cell lung cancer (SCLC) for decades. This retrospective single-center study aimed to determine
Cheng-Cheng Hwang +6 more
doaj +1 more source
circRNA meets gene amplification [PDF]
Non-coding RNA Investigation, 2018 Lung cancer remains the most common cause of cancer related death among both males and females globally accounting for 1.69 million deaths in 2015 (1). Of the different types of lung cancer, lung adenocarcinoma (LAC) is the most common (2). Given the prevalence and lethality of lung cancer the need to elucidate the mechanisms of this disease and to ...
Hisashi Tanaka +2 more
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Cells, 2022 Gene amplifications in amphibians and flies are known to occur during development and have been well characterized, unlike in mammalian cells, where they are predominantly investigated as an attribute of tumors.
Marie Minet +8 more
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Gene amplification and insecticide resistance
Pest Management Science, 2011 AbstractPesticide resistance in arthropods has been shown to evolve by two main mechanisms, the enhanced production of metabolic enzymes, which bind to and/or detoxify the pesticide, and mutation of the target protein, which makes it less sensitive to the pesticide.
Bass, C., Field, L. M.
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Neoplasia: An International Journal for Oncology Research, 2003 Signaling by the transforming growth factor (TGF)family members is transduced from the cell surface to the nucleus by the Smad group of intracellular proteins. Because we detected alterations on the long arm of chromosome 5, we examined the status of the
Drazen B. Zimonjic +5 more
doaj +1 more source
Massive gene amplification on a recently formed Drosophila Y chromosome. [PDF]
, 2019 Widespread loss of genes on the Y is considered a hallmark of sex chromosome differentiation. Here we show that the initial stages of Y evolution are driven by massive amplification of distinct classes of genes. The neo-Y chromosome of Drosophila miranda
Bachtrog, Doris +2 more
core +1 more source
Aminoglycoside Heteroresistance in
mSphere, 2018 Heteroresistance is a phenomenon where a subpopulation of cells exhibits higher levels of antibiotic resistance than the general population. Analysis of tobramycin resistance in Acinetobacter baumannii AB5075 using Etest strips demonstrated that colonies
Sarah E. Anderson +3 more
doaj +1 more source
OncoTarget, 2016 Immunomodulatory therapies, targeting the immune checkpoint receptor-ligand complex PD-1/PD-L1 have shown promising results in early phase clinical trials in solid malignancies, including carcinomas of the head and neck.
M. Straub +9 more
semanticscholar +1 more source