Results 41 to 50 of about 8,013,600 (393)
Gene amplification and insecticide resistance
Pest Management Science, 2011 AbstractPesticide resistance in arthropods has been shown to evolve by two main mechanisms, the enhanced production of metabolic enzymes, which bind to and/or detoxify the pesticide, and mutation of the target protein, which makes it less sensitive to the pesticide.
Bass, C., Field, L. M.
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Epigenetic regulation affects gene amplification in Drosophila development
Frontiers in Bioscience-Landmark, 2020 In Drosophila melanogaster, in response to developmental transcription factors, and by repeated initiation of DNA replication of four chorion genes, ovarian follicle cells, form an onion skin-type structure at the replication origins. The DNA replication
Hidetsugu Kohzaki +3 more
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OncoTarget, 2016 Immunomodulatory therapies, targeting the immune checkpoint receptor-ligand complex PD-1/PD-L1 have shown promising results in early phase clinical trials in solid malignancies, including carcinomas of the head and neck.
M. Straub +9 more
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A PCA3 gene-based transcriptional amplification system targeting primary prostate cancer. [PDF]
, 2015 Targeting specifically primary prostate cancer (PCa) cells for immune therapy, gene therapy or molecular imaging is of high importance. The PCA3 long non-coding RNA is a unique PCa biomarker and oncogene that has been widely studied.
Fradet, Yves +5 more
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Induction of Gene Amplification Contribute to Sulfonamide Resistance in Proteus mirabilis [PDF]
مجلة التربية والعلم, 2007 Thirty Isolates of Proteus mirabilis from different clinical sources (Urine, Bum, Ear, and Wounds) were recovered. All isolates were subjected to the series of confirming tests to insure that these isolates are Proteus mirabilis, which identified ...
Zeerak Abdulrahman
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Veterinary World, 2016 India being a developing country mainly depends on livestock sector for its economy. However, nowadays, there is emergence and reemergence of more transboundary animal diseases.
P. R. Sahoo +3 more
semanticscholar +1 more source
Genomic and phenotypic evolution of Escherichia coli in a novel citrate-only resource environment
eLife, 2020 Evolutionary innovations allow populations to colonize new ecological niches. We previously reported that aerobic growth on citrate (Cit+) evolved in an Escherichia coli population during adaptation to a minimal glucose medium containing citrate (DM25 ...
Zachary D Blount +11 more
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XDJ1, a gene encoding a novel non-essential DnaJ homologue from Saccharomyces cerevisiae [PDF]
, 1994 The gene encoding a novel DnaJ-like protein, termed Xdj1, has been identified by amplification of Saccharomyces cerevisiae genomic DNA. An open reading frame of 1380 bp was detected. Disruption of XDJ1 did not yield any detectable new phenotype. A double-
Caplan, Avrom J. +4 more
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Prognostic stratification of adult primary glioblastoma multiforme patients based on their tumor gene amplification profiles [PDF]
, 2018 [EN]everal classification systems have been proposed to address genomic heterogeneity of glioblastoma multiforme, but they either showed limited prognostic value and/or are difficult to implement in routine diagnostics.
Almeida, Maria Rosário +16 more
core +5 more sources
The MDM2 gene amplification database [PDF]
Nucleic Acids Research, 1998 The p53 tumor suppressor gene is inactivated in human tumors by several distinct mechanisms. The best characterized inactivation mechanisms are: (i) gene mutation; (ii) p53 protein association with viral proteins; (iii) p53 protein association with the MDM2 cellular oncoprotein. The MDM2 gene has been shown to be abnormally up-regulated in human tumors
David Jung +3 more
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