Results 41 to 50 of about 8,130,594 (350)

Mechanisms of IS26-Mediated Amplification of the aphA1 Gene Leading to Tobramycin Resistance in an Acinetobacter baumannii Isolate

Microbiology Spectrum, 2022
Enhanced levels of resistance to antibiotics arising from amplification of an antibiotic resistance gene that impact therapeutic options are increasingly observed. Amplification can also disclose novel phenotypes leading to treatment failure.
Christopher J. Harmer, Francois Lebreton, Jason Stam, Patrick T. McGann, Ruth M. Hall   +4 more
doaj   +1 more source

Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors

Scientific Reports, 2017
Identification of driver genes contributes to the understanding of cancer etiology and is imperative for the development of individualized therapies. Gene amplification is a major event in oncogenesis.
K. Ohshima, K. Hatakeyama, T. Nagashima, Yuko Watanabe, Kaori Kanto, Yuki Doi, Tomomi Ide, Y. Shimoda, Tomoe Tanabe, Sumiko Ohnami, S. Ohnami, M. Serizawa, Koji Maruyama, Y. Akiyama, K. Urakami, M. Kusuhara, T. Mochizuki, K. Yamaguchi   +17 more
semanticscholar   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Study of C-MYC amplification and expression in Iranian gastric cancer samples using CISH and IHC methods

Advanced Biomedical Research, 2015
Background: Gastric cancer is the fourth most frequent malignancy and the second cause of cancer-related mortality worldwide. It has been suggested that in gastric carcinogenesis, the C-MYC gene has an important function.
Malihea Khaleghian, Issa Jahanzad, Abbas Shakoori, Farid Azmoudeh Ardalan, Cyrus Azimi   +4 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Molecular Amplification and Cell Culturing Efficiency for Enteroviruses’ Detection in Cerebrospinal Fluids of Algerian Patients Suffering from Meningitis

Viruses
Enteroviruses (EVs) represent a major cause of viral meningitis, being responsible for nearly 1 billion infections each year worldwide. Several techniques were developed to obtain better diagnostic results of EV infections.
Abdelwahab Rai, Zohra Ammi, Dahbia Leila Anes-Boulahbal, Aymen Amin Assadi, Abdeltif Amrane, Oussama Baaloudj, Lotfi Mouni   +6 more
doaj   +1 more source

High-Resolution Mapping of Genomic Imbalance and Identification of Gene Expression Profiles Associated with Differential Chemotherapy Response in Serous Epithelial Ovarian Cancer

Neoplasia: An International Journal for Oncology Research, 2005
Array comparative genomic hybridization (aCGH) and microarray expression profiling were used to subclassify DNA and RNA alterations associated with differential response to chemotherapy in ovarian cancer.
Marcus Bernardini, Chung-Hae Lee, Ben Beheshti, Mona Prasad, Monique Albert, Paula Marrano, Heather Begley, Patricia Shaw, Al Covens, Joan Murphy, Barry Rosen, Salomon Minkin, Jeremy A. Squire, Pascale F. Macgregor   +13 more
doaj   +1 more source

HER2 Status in Colorectal Cancer: Its Clinical Significance and the Relationship between HER2 Gene Amplification and Expression

PLoS ONE, 2014
This study aimed at determining the incidence and clinical implications of HER2 status in primary colorectal cancer (CRC). HER2 status was investigated in two retrospective cohorts of 365 consecutive CRC patients (cohort 1) and 174 advanced CRC patients ...
A. Seo, Y. Kwak, Duck-Woo Kim, Sung-Bum Kang, G. Choe, W. Kim, H. Lee   +6 more
semanticscholar   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Epigenetic regulation affects gene amplification in Drosophila development

Frontiers in Bioscience-Landmark, 2020
In Drosophila melanogaster, in response to developmental transcription factors, and by repeated initiation of DNA replication of four chorion genes, ovarian follicle cells, form an onion skin-type structure at the replication origins. The DNA replication
Hidetsugu Kohzaki, Maki Asano, Yota Murakami, Alexander Mazo   +3 more
doaj   +1 more source