Results 91 to 100 of about 743,593 (306)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Spatiotemporal single-cell architecture of gene expression in the Caenorhabditis elegans germ cells

Cell Discovery
Spermatogenesis is an intricate and tightly controlled process encompassing various layers of gene expression regulation. Despite the advance of our current understanding, the developmental trajectory and regulatory mechanisms dictating spermatogenesis ...
Lili Li, Xiaoyin Tang, Xuanxuan Guo, Di Rao, Lin Zeng, Junchao Xue, Shuxian Liu, Shikui Tu, En-Zhi Shen   +8 more
doaj   +1 more source

Genomic control of patterning [PDF]

, 2009
The development of multicellular organisms involves the partitioning of the organism into territories of cells of specific structure and function. The information for spatial patterning processes is directly encoded in the genome.
Davidson, Eric H., Peter, Isabelle S.
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Conserved noncoding transcription and core promoter regulatory code in early Drosophila development

eLife, 2017
Multicellular development is driven by regulatory programs that orchestrate the transcription of protein-coding and noncoding genes. To decipher this genomic regulatory code, and to investigate the developmental relevance of noncoding transcription, we ...
Philippe J Batut, Thomas R Gingeras
doaj   +1 more source

Gene expression in Leishmania is regulated predominantly by gene dosage [PDF]

, 2017
Leishmania tropica, a unicellular eukaryotic parasite present in North and East Africa, the Middle East, and the Indian subcontinent, has been linked to large outbreaks of cutaneous leishmaniasis in displaced populations in Iraq, Jordan, and Syria. Here,
Berriman, Matthew, Beverley, Stephen M., Cotton, James A., Durrant, Caroline, Grigg, Michael E., Iantorno, Stefano A., Khan, Asis, Myler, Peter, Ouellette, Marc, Sacks, David L., Sanders, Mandy J., Warren, Wesley C., Weiss, Louis M.   +12 more
core   +3 more sources

Post-transcriptional gene expression regulation in developmental disorders

, 2021
Gene expression regulation is a set of critical biological processes that give rise to the diversity of cell types across tissues and development stages. Noncoding regions of the genome (intergenic + intronic, >98% of genome) play an important role in these processes, with noncoding genetic variation quantitatively affecting transcriptional activity,
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Transcriptome dynamics in the asexual cycle of the chordate Botryllus schlosseri [PDF]

, 2016
Background: We performed an analysis of the transcriptome during the blastogenesis of the chordate Botryllus schlosseri, focusing in particular on genes involved in cell death by apoptosis. The tunicate B.
Ballarin, Loriano, Ballin, Francesca, Campagna, Davide, Franchi, Nicola, Gasparini, Fabio, Manni, Lucia, Valle, Giorgio, Vitulo, Nicola   +7 more
core   +3 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source