Results 101 to 110 of about 918,759 (321)
FEBS Letters, EarlyView.Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt +4 more
wiley +1 more source
Epigenetic regulation of developmental expression of Cyp2d genes in mouse liver
Acta Pharmaceutica Sinica B, 2012 AbstractCYP2D6 expression in liver is age-dependent. Because epigenetic mechanisms, such as DNA methylation and histone modifications, modulate age-related gene expression during development, and are highly conserved among species, the current study examined the epigenetic regulation of age-related expression of the Cyp2d genes in mouse liver.
Ye Li, Xiao-bo Zhong
openaire +3 more sources
Inferring gene expression dynamics via functional regression analysis
BMC Bioinformatics, 2008 Background Temporal gene expression profiles characterize the time-dynamics of expression of specific genes and are increasingly collected in current gene expression experiments.
Leng Xiaoyan +2 more
doaj +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source
Control of gene expression through the nonsense-mediated RNA decay pathway
Cell & Bioscience, 2017 Nonsense-mediated RNA decay (NMD) was originally discovered as a cellular surveillance pathway that safeguards the quality of mRNA transcripts in eukaryotic cells.
Andrew Nickless +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink +6 more
wiley +1 more source
Does cohesin regulate developmental gene expression in Drosophila ? [PDF]
Proceedings of the National Academy of Sciences, 2008 Cohesin is a conserved protein complex with a well documented role in providing stable but reversible connections between sister chromatids during both mitosis and meiosis. Cohesin consists of two long coiled-coil proteins (SMC1 and SMC3) and two non-SMC subunits (SCC1/Rad21 and SCC3/SA) that combine to form a ring-like structure.
openaire +2 more sources
Frontiers in Ecology and EvolutionPrey can respond to predation risk through developmental plasticity, generating anti-predator phenotypes. These inducible defenses arise from changes to the stress axis, and neuroendocrine-triggered gene regulation is a likely mechanism influencing such ...
Tucker W. Cambridge +7 more
doaj +1 more source