Results 81 to 90 of about 743,593 (306)

Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function. [PDF]

, 2019
Rett syndrome (RTT) is a pervasive developmental disorder caused by mutations in MECP2. Complete loss of MECP2 function in males causes congenital encephalopathy, neurodevelopmental arrest, and early lethality.
Carromeu, Cassiano, Freitas, Beatriz CG, Ghosh, Anirvan, Hu, Xindao, Kim, Jean J, Lavallée-Adam, Mathieu, Miller, Meghan T, Muotri, Alysson R, Savas, Jeffrey N, Yates, John R   +9 more
core   +2 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Phylogeny-wide conservation and change in developmental expression, cell-type specificity and functional domains of the transcriptional regulators of social amoebas [PDF]

, 2019
Background: Dictyostelid social amoebas self-organize into fruiting bodies, consisting of spores and up to four supporting cell types in the phenotypically most complex taxon group 4.
Chen, Zhi-Hui, Forbes, Gillian, Kin, Koryu, Lawal, Hajara M., Schaap, Pauline, Schilde, Christina, Yamada, Yoko   +6 more
core   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Sequential Response to Multiple Developmental Network Circuits Encoded in an Intronic cis-Regulatory Module of Sea Urchin hox11/13b

Cell Reports, 2017
Summary: Gene expression in different spatial domains is often controlled by separate cis-regulatory modules (CRMs), but regulatory states determining CRM activity are not only distinct in space, they also change continuously during developmental time ...
Miao Cui, Erika Vielmas, Eric H. Davidson, Isabelle S. Peter   +3 more
doaj   +1 more source

Temperature responsiveness of gilthead sea bream bone; an in vitro and in vivo approach [PDF]

, 2018
This study aimed to characterize the molecules involved in osteogenesis in seabream and establish using in vitro/in vivo approaches the responsiveness of selected key genes to temperature.
Capilla, Encarnacion, Costa, Rita, Gisbert, Enric, Gutierrez, Joaquim, Martins, Rute, Navarro, Isabel, Patricia Mateus, Ana, Power, Deborah M., Riera-Heredia, Natalia   +8 more
core   +3 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Shaping Robust System through Evolution

, 2008
Biological functions are generated as a result of developmental dynamics that form phenotypes governed by genotypes. The dynamical system for development is shaped through genetic evolution following natural selection based on the fitness of the ...
de Visser J. A. G. M., Edwards A. W. F., Einstein A., Fisher R. A., Futuyma D. J., Kaneko K., Kirschner M. W., Kunihiko Kaneko, Schmalhausen I. I., Waddington C. H., West-Eberhard M. J.   +10 more
core   +1 more source

Plant responses to photoperiod [PDF]

, 2009
Photoperiod controls many developmental responses in animals, plants and even fungi. The response to photoperiod has evolved because daylength is a reliable indicator of the time of year, enabling developmental events to be scheduled to coincide with ...
Abe, Achard, Adams, Adams, Alabadi, An, Asai, Aukerman, Balasubramanian, Banerjee, Batutis, Beales, Ben-Naim, Berardini, Bernier, Blazquez, Blázquez, Blázquez, Bollman, Bongard-Pierce, Borchert, Bouveret, Bäurle, Böhlenius, Cerdán, Chae, Chailkhyan, Chen, Chen, Chien, Chincinska, Clarke, Cockcroft, Corbesier, David, Devlin, Doi, Dudley, Duncan, Fahlgren, Farré, Foster, Fowler, Gandikota, Gardner, Giavalisco, Goldman, Gonthier, Grigg, Hackett, Halliday, Hayama, Hayama, Haywood, He, He, Henderson, Heyer, Holm, Hotta, Hsu, Hunter, Hunter, Imaizumi, Imaizumi, Izawa, Jackson, Jackson, Jackson, Jackson, Jaeger, Jang, Jung, Kanrar, Kelly, Kim, Kim, Kim, Kim, Kojima, Komiya, Kotake, Kusnetsov, Laubinger, Lauter, Lee, Lee, Lin, Martinez-Garcia, Martínez, Mathieu, McClung, Michael, Moon, Mouradov, Más, Nilsson, Onouchi, Orkwiszewski, Osterlund, Park, Peragine, Pineiro, Poethig, Poethig, Pouteau, Razem, Reeves, Roberts, Robinson, Robson, Roden, Rodriguez-Falcon, Saijo, Samach, Sawa, Schmid, Schwarz, Searle, Seo, Singer, Sivitz, Smith, Somers, Souer, Stadler, Steward, Suàrez-López, Swiezewski, Takada, Takeno, Tamaki, Telfer, Tessadori, Thomas, Turner, Valverde, Vega, Von Arnim, Wang, Wang, Weigel, Wenkel, Wigge, Willmann, Wu, Xie, Yamaguchi, Yan, Yanovsky, Yanovsky, Yoo, Yoo, Yu, Zeevaart   +154 more
core   +1 more source

Developmental regulation of lck gene expression in T lymphocytes. [PDF]

The Journal of experimental medicine, 1991
In the mouse and human, mRNA transcripts encoding the lymphocyte-specific protein tyrosine kinase p56lck are derived from two separate promoters resulting in heterogeneity in the 5' untranslated region sequence. The proximal promoter lies just 5' to the coding region for the gene and is active only in thymocytes.
R S, Wildin, A M, Garvin, S, Pawar, D B, Lewis, K M, Abraham, K A, Forbush, S F, Ziegler, J M, Allen, R M, Perlmutter   +8 more
openaire   +2 more sources