Results 31 to 40 of about 472,464 (265)

Human Cytomegalovirus UL34 Early and late Proteins Are Essential for Viral Replication

Viruses, 2014
UL34 is one of the ~50 genes of human cytomegalovirus (HCMV) required for replication in cell culture in human fibroblasts. UL34 encodes highly related early (UL34a) and late (UL34b) proteins that are virtually identical, with the early protein ...
Rico Rana, Bonita J. Biegalke
doaj   +1 more source

Infection of apple by apple stem grooving virus leads to extensive alterations in gene expression patterns but no disease symptoms. [PDF]

PLoS ONE, 2014
To understand the molecular basis of viral diseases, transcriptome profiling has been widely used to correlate host gene expression change patterns with disease symptoms during viral infection in many plant hosts. We used infection of apple by Apple stem
Shanyi Chen, Ting Ye, Lu Hao, Hui Chen, Shaojie Wang, Zaifeng Fan, Liyun Guo, Tao Zhou   +7 more
doaj   +1 more source

Cell type specific and viral regulation of visna virus gene expression

Virus Research, 1990
Regulation of gene expression of visna virus and other lentiviruses in vivo and in vitro is dependent on both cellular and viral factors. Differentiation and activation of the target cell is essential for transcriptional activation of the viruses. The cellular factors then activate viral transcription and expression of viral genes and viral regulatory ...
J E, Clements, D H, Gabuzda, S L, Gdovin
openaire   +2 more sources

Visna virus encodes a post-transcriptional regulator of viral structural gene expression [PDF]

Proceedings of the National Academy of Sciences, 1990
Visna virus is an ungulate lentivirus that is distantly related to the primate lentiviruses, including human immunodeficiency virus type 1 (HIV-1). Replication of HIV-1 and of other complex primate retroviruses, including human T-cell leukemia virus type I (HTLV-I), requires the expression in trans of a virally encoded post-transcriptional activator of
L S, Tiley, P H, Brown, S Y, Le, J V, Maizel, J E, Clements, B R, Cullen   +5 more
openaire   +4 more sources

Regulation of Viral Intermediate Gene Expression by the Vaccinia Virus B1 Protein Kinase [PDF]

Journal of Virology, 2001
ABSTRACT The B1 gene of vaccinia virus encodes a serine/threonine protein kinase that is expressed early after infection. Under nonpermissive conditions, temperature-sensitive mutants ( ts 2 and ts 25) that map to B1 fail to efficiently replicate viral DNA.
G R, Kovacs, N, Vasilakis, B, Moss
openaire   +2 more sources

Negative regulation of interferon-β gene expression during acute and persistent virus infections. [PDF]

PLoS ONE, 2011
The production of type I interferons (IFNs) in response to viral infections is critical for antiviral immunity. However, IFN production is transient, and continued expression can lead to inflammatory or autoimmune diseases.
Junqiang Ye, Tom Maniatis
doaj   +1 more source

The Unique IR2 Protein of Equine Herpesvirus 1 Negatively Regulates Viral Gene Expression [PDF]

Journal of Virology, 2006
ABSTRACT The IR2 protein (IR2P) is a truncated form of the immediate-early protein (IEP) lacking the essential acidic transcriptional activation domain (TAD) and serine-rich tract and yet retaining binding domains for DNA and TFIIB and nuclear localization signal (NLS).
Seong K, Kim, Byung C, Ahn, Randy A, Albrecht, Dennis J, O'Callaghan   +3 more
openaire   +2 more sources

Herpes simplex virus 1 ICP22 inhibits the transcription of viral gene promoters by binding to and blocking the recruitment of P-TEFb. [PDF]

PLoS ONE, 2012
ICP22 is a multifunctional herpes simplex virus 1 (HSV-1) immediate early protein that functions as a general repressor of a subset of cellular and viral promoters in transient expression systems.
Lei Guo, Wen-juan Wu, Long-ding Liu, Li-chun Wang, Ying Zhang, Lian-qiu Wu, Ying Guan, Qi-han Li   +7 more
doaj   +1 more source

Optimization of the Tet-On system for regulated gene expression through viral evolution [PDF]

Gene Therapy, 2006
The ability to control (trans)gene expression is important both for basic biological research and applications such as gene therapy. In vivo use of the inducible tetracycline (Tc)-regulated gene expression system (Tet-On system) is limited by its low sensitivity for the effector doxycycline (dox).
Zhou, X., Vink, M., Klaver, B., Berkhout, B., Das, A. T.   +4 more
openaire   +3 more sources

YTHDF1 and YTHDC1 m6A reader proteins regulate HTLV-1 tax and hbz activity

Journal of Virology
Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus responsible for adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a progressive neurodegenerative disease.
Emily M. King, Amanda Midkiff, Karsyn McClain, Sanggu Kim, Amanda R. Panfil   +4 more
doaj   +1 more source