Results 11 to 20 of about 9,231 (134)

Polymorphism of the Human Immunodeficiency Virus Type 1 in Brazil: Genetic Characterization of the nef Gene and Implications for Vaccine Design

Memorias do Instituto Oswaldo Cruz, 2002
Most of the Brazilian HIV-1 samples have been characterized based on the structural genes (env, gag and pol) and no data concerning the variability of the accessory genes such as nef have been available so far.
ML Guimarães, AS Moreira, MG Morgado
doaj   +1 more source

Development of a Novel Q-body Using an In Vivo Site-Specific Unnatural Amino Acid Incorporation System

Sensors, 2018
A Q-body capable of detecting target molecules in solutions could serve as a simple molecular detection tool. The position of the fluorescent dye in a Q-body affects sensitivity and therefore must be optimized.
Yoichi Kurumida, Nobuhiro Hayashi
doaj   +1 more source

nef Gene Is Required for Robust Productive Infection by Simian Immunodeficiency Virus of T-Cell-Rich Paracortex in Lymph Nodes [PDF]

Journal of Virology, 2003
ABSTRACT The pathogenesis of AIDS virus infection in a nonhuman primate AIDS model was studied by comparing plasma viral loads, CD4 + T-cell subpopulations in peripheral blood mononuclear cells, and simian immunodeficiency virus (SIV) infection in lymph nodes for rhesus macaques infected with a pathogenic ...
Chie, Sugimoto, Kei, Tadakuma, Isao, Otani, Takashi, Moritoyo, Hirofumi, Akari, Fumiko, Ono, Yasuhiro, Yoshikawa, Tetsutaro, Sata, Shuji, Izumo, Kazuyasu, Mori   +9 more
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Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2.

PLoS Pathogens, 2009
Tetherin, also known as BST2, CD317 or HM1.24, was recently identified as an interferon-inducible host-cell factor that interferes with the detachment of virus particles from infected cells.
Bin Jia, Ruth Serra-Moreno, William Neidermyer, Andrew Rahmberg, John Mackey, Ismael Ben Fofana, Welkin E Johnson, Susan Westmoreland, David T Evans   +8 more
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HIV-1 Group P is unable to antagonize human tetherin by Vpu, Env or Nef

Retrovirology, 2011
Background A new subgroup of HIV-1, designated Group P, was recently detected in two unrelated patients of Cameroonian origin. HIV-1 Group P phylogenetically clusters with SIVgor suggesting that it is the result of a cross-species transmission from ...
Sauter Daniel, Hué Stéphane, Petit Sarah J, Plantier Jean-Christophe, Towers Greg J, Kirchhoff Frank, Gupta Ravindra K   +6 more
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The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages. [PDF]

The Journal of experimental medicine, 1994
Considerable controversy and uncertainty have surrounded the biological function of the Human Immunodeficiency Virus (HIV)-1 nef gene product. Initial studies suggested that this early, nonstructural viral protein functioned as a negative regulatory factor; thus, it was proposed to play a role in establishing or maintaining viral latency.
Miller, MD, Warmerdam, MT, Gaston, I, Greene, WC, Feinberg, MB   +4 more
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Inhibition of Protein Synthesis by the Human Immunodeficiency Virus Type 1 nef Gene Product

Journal of General Virology, 1994
During productive infection of human T lymphocytes in cell culture, the expression of human immunodeficiency virus type 1 is temporally regulated by virus-encoded regulatory proteins. Among these Nef, whose function has not been clearly elucidated, is thought to alter CD4+ T cells.
L, Poulin, M, Fauchon, A, Darveau, J A, Levy   +3 more
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Simian immunodeficiency virus Nef gene regulates the production of 2-LTR circles in vivo

Virology, 2003
The replication dynamics of simian immunodeficiency virus (SIVmac32H-C8), attenuated through discrete genetic disruption of the nef gene, were compared with the wild-type parental clone (SIVmac32H-J5) using quantitative molecular methods. The primary viraemia of both infections were similar during the first week, but peaked on Day 10 at higher levels ...
Clarke, S, Almond, N, Berry, N
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Functional association between the nef gene product and gag‐pol region of HIV‐1

FEBS Letters, 2000
Nef gene function is diverse among virus isolates of primate immunodeficiency viruses. We found differential effects of nef mutation on the virus replication between two HIV‐1 clones, NL432 and LAI. The nef mutation in NL432 affected the infectivity more severely compared with that in LAI, although the Nef functions of both clones were comparable ...
Ono, Takeshi, Iwatani, Yasumasa, Nishimura, Akiko, Ishimoto, Akinori, Sakai, Hiroyuki   +4 more
openaire   +2 more sources

Notch4 activation aggravates NF-κB-mediated inflammation in HIV-1-associated nephropathy

Disease Models & Mechanisms, 2019
Notch pathway activation plays a central role in the pathogenesis of many glomerular diseases. We have previously shown that Notch4 expression was upregulated in various renal cells in human immunodeficiency virus (HIV)-associated nephropathy (HIVAN ...
Rajni Vaid Puri, Sireesha Yerrathota, Trisha Home, Jessica Y. Idowu, V. Praveen Chakravarthi, Christopher J. Ward, Pravin C. Singhal, Gregory B. Vanden Heuvel, Timothy A. Fields, Madhulika Sharma   +9 more
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