Results 41 to 50 of about 5,527,747 (326)

A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila. [PDF]

, 2011
The unique architecture of neurons requires the establishment and maintenance of polarity, which relies in part on microtubule-based transport to deliver essential cargo into dendrites.
Goldstein, Lawrence SB, Henthorn, Kristina Schimmelpfeng, Herrera, Cheryl, Roux, Meike Sabina   +3 more
core   +2 more sources

Análisis genético en APC, KRAS y TP53 en pacientes con cáncer de estómago y colon

Revista de Gastroenterología de México, 2014
Antecedentes: El cáncer de estómago (CE) y colorrectal (CCR) presentan altas tasas de incidencia y mortalidad en la población mundial. Estas 2 neoplasias se caracterizan por tener una gran heterogeneidad genética.
K.A. Palacio-Rúa, L.F. Isaza-Jiménez, E. Ahumada-Rodríguez, H. Ceballos-García, C.M. Muñetón-Peña   +4 more
doaj   +1 more source

Transcriptome analysis revealed unique genes as targets for the anti-inflammatory action of activated protein C in human macrophages. [PDF]

PLoS ONE, 2010
BACKGROUND: Activated protein C (APC) has been introduced as a therapeutic agent for treatment of patients with severe sepsis due to its unique anticoagulant and anti-inflammatory properties in the vascular system.
Claudia P Pereira, Esther B Bachli, Dominik J Schaer, Gabriele Schoedon   +3 more
doaj   +1 more source

The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes.

Genes & Development, 2006
The APC tumor suppressor controls the stability and nuclear export of beta-catenin (beta-cat), a transcriptional coactivator of LEF-1/TCF HMG proteins in the Wnt/Wg signaling pathway. We show here that beta-cat and APC have opposing actions at Wnt target
J. Sierra, Tomonori Yoshida, C. Joazeiro, K. Jones   +3 more
semanticscholar   +1 more source

Mad2, Bub3, and Mps1 regulate chromosome segregation and mitotic synchrony in Giardia intestinalis, a binucleate protist lacking an anaphase-promoting complex. [PDF]

, 2014
The binucleate pathogen Giardia intestinalis is a highly divergent eukaryote with a semiopen mitosis, lacking an anaphase-promoting complex/cyclosome (APC/C) and many of the mitotic checkpoint complex (MCC) proteins.
Cande, W Zacheus, Vicente, Juan-Jesus
core   +2 more sources

Arabidopsis ULTRAVIOLET-B-INSENSITIVE4 maintains cell division activity by temporal inhibition of the anaphase-promoting complex/cyclosome [PDF]

, 2011
The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin ligase that regulates progression through the cell cycle by marking key cell division proteins for destruction.
Berckmans, Barbara, Boudolf, Véronique, De Jaeger, Geert, De Veylder, Lieven, De Wit, Kevin, Heyman, Jefri, Koncz, Csaba, Lessa Alvim Kamei, Claire, Van Den Daele, Hilde, Verkest, Aurine   +9 more
core   +2 more sources

Antitumor Molecular Mechanism of Chlorogenic Acid on Inducting Genes GSK-3β and APC and Inhibiting Gene β-Catenin

Journal of Analytical Methods in Chemistry, 2013
Objective. Inhibiting gene β-catenin and inducting genes GSK-3β and APC, promoting the tumor cell apoptosis in Wnt pathway, by chlorogenic acid were discussed (CGA). Method. The different genes were scanned by the 4*44K mouse microarray chips.
Ruoshi Xu, Qiumei Kang, Jie Ren, Zukun Li, Xiaoping Xu   +4 more
doaj   +1 more source

Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human

, 2019
The Hedgehog (Hh) and Wnt/β-Catenin (Wnt) cascades are morphogen pathways whose pronounced influence on adult liver metabolism has been identified in recent years.
Aleithe, S., Brosch, M., Brusch, L., Damm, G., Gajowski, R., Gebhardt, R., Hampe, J., Hoehme, S., Hoffmann, U., Kolbe, E., Kücken, M., Matz-Soja, M., Meierhofer, D., Ott, F., Rennert, C., Schafmayer, C., Seehofer, D., Seifert, M., Spormann, L., Stöpel, C., von Schoenfels, W.   +20 more
core   +1 more source

Two Steps Methylation Specific PCR for Assessment of APC Promoter Methylation in Gastric Adenocarcinoma [PDF]

Journal of Sciences, Islamic Republic of Iran, 2011
Gastric Cancer (GC) is the second most common cancer in the world and a leading cause of cancer-related mortality. Methylation of promoter CpG islands (CGIs) belonging to tumor suppressor genes causes transcriptional silencing of their corresponding ...
Rastgar Jazii
doaj  

Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation

PLoS ONE, 2016
Mutations in TGFBR2, a component of the transforming growth factor (TGF)-β signaling pathway, occur in high-frequency microsatellite instability (MSI-H) colorectal cancer (CRC).
Masashi Miguchi, T. Hinoi, M. Shimomura, Tomohiro Adachi, Yasufumi Saito, Hiroaki Niitsu, Masatoshi Kochi, Haruki Sada, Y. Sotomaru, T. Ikenoue, K. Shigeyasu, K. Tanakaya, Y. Kitadai, K. Sentani, N. Oue, W. Yasui, H. Ohdan   +16 more
semanticscholar   +1 more source