Integrated genomic analysis of the 8q24 amplification in endometrial cancers identifies ATAD2 as essential to MYC-dependent cancers. [PDF]
PLoS ONE, 2013 Chromosome 8q24 is the most commonly amplified region across multiple cancer types, and the typical length of the amplification suggests that it may target additional genes to MYC.
Maria B Raeder +20 more
doaj +21 more sources
MYC-type transcription factors, MYC67 and MYC70, interact with ICE1 and negatively regulate cold tolerance in Arabidopsis [PDF]
Scientific Reports, 2018 The expression of hundreds of genes is induced by low temperatures via a cold signaling pathway. ICE1, a MYC-type transcription factor, plays an important role in the induction of CBF3/DREB1A to control cold-responsive genes and cold tolerance.
Masaru Ohta +8 more
doaj +3 more sources
Identification of key genes related to lymphangiogenesis in venous thromboembolism through transcriptomics and verification by RT-qPCR [PDF]
Frontiers in MedicineBackgroundVenous thromboembolism (VTE), a life-threatening cardiovascular disorder, involves complex interactions between thrombosis and immune dysregulation. Lymphangiogenesis-related genes (LRGs) may directly induce thrombosis by regulating endothelial
Yusheng Lin +6 more
doaj +2 more sources
Global regulation of nucleotide biosynthetic genes by c-Myc. [PDF]
PLoS ONE, 2008 The c-Myc transcription factor is a master regulator and integrates cell proliferation, cell growth and metabolism through activating thousands of target genes.
Yen-Chun Liu +8 more
doaj +1 more source
WDR5 facilitates recruitment of N-MYC to conserved WDR5 gene targets in neuroblastoma cell lines
Oncogenesis, 2023 Collectively, the MYC family of oncoprotein transcription factors is overexpressed in more than half of all malignancies. The ability of MYC proteins to access chromatin is fundamental to their role in promoting oncogenic gene expression programs in ...
Leigh A. Bumpous +12 more
doaj +1 more source
Global identification of Myc target genes reveals its direct role in mitochondrial biogenesis and its E-box usage in vivo. [PDF]
PLoS ONE, 2008 The Myc oncoprotein is a transcription factor involved in a variety of human cancers. Overexpression of Myc is associated with malignant transformation.
Jonghwan Kim +2 more
doaj +1 more source
N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b. [PDF]
PLoS ONE, 2009 myc genes are best known for causing tumors when overexpressed, but recent studies suggest endogenous myc regulates pluripotency and self-renewal of stem cells.
Rebecca Cotterman, Paul S Knoepfler
doaj +1 more source
Gene Transactivation and Transrepression in MYC-Driven Cancers [PDF]
International Journal of Molecular Sciences, 2021 MYC is a proto-oncogene regulating a large number of genes involved in a plethora of cellular functions. Its deregulation results in activation of MYC gene expression and/or an increase in MYC protein stability. MYC overexpression is a hallmark of malignant growth, inducing self-renewal of stem cells and blocking senescence and cell differentiation ...
Scafuro M. +4 more
openaire +3 more sources
Nuclear AXIN2 represses MYC gene expression [PDF]
Biochemical and Biophysical Research Communications, 2014 The β-catenin transcriptional coactivator is the key mediator of the canonical Wnt signaling pathway. In the absence of Wnt, β-catenin associates with a cytosolic and multi-protein destruction complex where it is phosphorylated and targeted for proteasomal degradation.
Sherri A, Rennoll +2 more
openaire +2 more sources
Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. [PDF]
PLoS ONE, 2009 BACKGROUND:The Myc oncoprotein, a transcriptional regulator involved in the etiology of many different tumor types, has been demonstrated to play an important role in the functions of embryonic stem (ES) cells.
Chin-Hsing Lin +4 more
doaj +1 more source