Early and late effects of pharmacological ALK inhibition on the neuroblastoma transcriptome [PDF]
, 2017 Background: Neuroblastoma is an aggressive childhood malignancy of the sympathetic nervous system. Despite multi-modal therapy, survival of high-risk patients remains disappointingly low, underscoring the need for novel treatment strategies.
Cannoodt, Robrecht +6 more
core +3 more sources
PLoS ONE, 2009 BackgroundThe MYC oncogene contributes to induction and growth of many cancers but the full spectrum of the MYC transcriptional response remains unclear.Methodology/principal findingsUsing microarrays, we conducted a detailed kinetic study of genes that ...
Sanjay Chandriani +6 more
doaj +1 more source
Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice. [PDF]
, 2016 Alterations of specific genes can modulate aging. Myc, a transcription factor that regulates the expression of many genes involved in critical cellular functions was shown to have a role in controlling longevity.
Boyd, Kelli +3 more
core +2 more sources
Target gene-independent functions of MYC oncoproteins
Nature Reviews Molecular Cell Biology, 2020 Oncoproteins of the MYC family are major drivers of human tumorigenesis. Since a large body of evidence indicates that MYC proteins are transcription factors, studying their function has focused on the biology of their target genes. Detailed studies of MYC-dependent changes in RNA levels have provided contrasting models of the oncogenic activity of MYC
Apoorva Baluapuri +2 more
openaire +3 more sources
Restoration of miR-193a expression is tumor-suppressive in MYC amplified Group 3 medulloblastoma
Acta Neuropathologica Communications, 2020 Medulloblastoma, a highly malignant pediatric brain tumor, consists of four molecular subgroups, namely WNT, SHH, Group 3, and Group 4. The expression of miR-193a, a WNT subgroup-specific microRNA, was found to be induced by MYC, an oncogenic target of ...
Harish Shrikrishna Bharambe +4 more
doaj +1 more source
AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells. [PDF]
PLoS ONE, 2012 Upon activation, B cells divide, form a germinal center, and express the activation induced deaminase (AID), an enzyme that triggers somatic hypermutation of the variable regions of immunoglobulin (Ig) loci. Recent evidence indicates that at least 25% of
Hillary Selle Gramlich +2 more
doaj +1 more source
N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells. [PDF]
PLoS ONE, 2012 Here we examine the functions of the Myc cofactor and histone acetyltransferase, GCN5/KAT2A, in neural stem and precursor cells (NSC) using a conditional knockout approach driven by nestin-cre.
Verónica Martínez-Cerdeño +6 more
doaj +1 more source
Epstein-Barr virus nuclear antigen 3A protein regulates CDKN2B transcription via interaction with MIZ-1 [PDF]
, 2014 The Epstein-Barr virus (EBV) nuclear antigen 3 family of protein is critical for the EBV-induced primary B-cell growth transformation process. Using a yeast two-hybrid screen we identified 22 novel cellular partners of the EBNA3s. Most importantly, among
Bazot, Q +11 more
core +6 more sources
Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR). [PDF]
PLoS ONE, 2010 We investigated mTOR regulation of gene expression by studying rapamycin effect in two hepatic cell lines, the non-tumorigenic WB-F344 cells and the tumorigenic WB311 cells.
Rosa H Jimenez +7 more
doaj +1 more source
Cells, 2021 Canines are useful in mammalian preclinical studies because they are larger than rodents and share many diseases with humans. Canine fetal fibroblast cells (CFFs) are an easily accessible source of somatic cells.
So Hee Kim +6 more
doaj +1 more source