Results 161 to 170 of about 23,557 (205)

Molecular evolution of Sry and Sox gene

Gene, 2000
The mammalian Sry on the short arm of the Y chromosome encodes a nuclear factor-like protein harboring a DNA-binding domain known as the HMG box. The Sox genes encode similar factor like proteins, but the sequence similarity of the HMG box to that of Sry is variable as being at least 60%.
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Wilms' tumor suppressor gene (WT1) as a target gene of SRY function in a mouse ES cell line transfected with SRY

The International Journal of Developmental Biology, 1998
With the aim of identifying the gene(s) located downstream from SRY, we transfected an ES cell line with XX karyotype, TMA-18, with a Sry DNA construct and established cell lines, TS18-1 and TS18-2, where the transfected Sry was expressed in the functional linear mRNA form.
Y, Toyooka, S S, Tanaka, O, Hirota, S, Tanaka, N, Takagi, K, Yamanouchi, H, Tojo, C, Tachi   +7 more
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Candidate genes in complete and partial XY sex reversal: Mutation analysis of SRY, SRY-related genes and FTZ-F1

Molecular and Cellular Endocrinology, 1998
The sexual phenotype is established in three steps: (1) the sex chromosome constitution; (2) the differentiation of the gonads; and (3) the response of the internal and external genitalia to the hormones produced by the differentiated gonads. Errors that occur at any of these stages can result in defective sexual differentiation.
H N, Lim, S H, Freestone, D, Romero, C, Kwok, I A, Hughes, J R, Hawkins   +5 more
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Characterization of an SRY-like gene, DSox14 , from Drosophila

Gene, 2001
We have characterized the DSox14 gene, a new member of the family of transcription factors related to the mammalian sex determining factor, SRY. It contains two exons and the intron is large for Drosophila at 2.8 kb. The encoded protein consists of 691 amino acids (72 kDa) and includes an HMG box domain, which is closely related to the mouse Sox4 DNA ...
A C, Sparkes, K L, Mumford, U A, Patel, S F, Newbury, C, Crane-Robinson   +4 more
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A novel Xenopus laevis SRY-related gene, xSox33

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2003
The sex-determining region Y (SRY) gene and its related Sox genes encode transcriptional regulatory factors. In this study, we isolated and sequenced a novel Sox cDNA from African clawed frog (Xenopus laevis). The Sox gene was named xSox33. xSox33 was revealed to encode 244 amino acids.
Jun, Hagiuda, Yoshiki, Hiraoka, Masanori, Hasegawa, Motoyuki, Ogawa, Sadakazu, Aiso   +4 more
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Analysis of SRY Gene in 8 Cases of Sex Abnormality

Current Medical Science, 2004
In order to investigate the relationship between sex dysplasia and sex-determining region Y (SRY) gene, 8 patients with sexual abnormality were analyzed by cytogenetic and molecular genetic methods. Fluorescence in situ hybridization (FISH) using PY3.4, X alpha satellite, and SRY probes was performed in each case to analyze the sex chromosome ...
Hui, Wang, Yun, Teng, Hong, Tian, Yanping, Tang, Yan, Chen, Zhenrong, Yang   +5 more
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Sequence evolution of SRY gene within Bovidae family

Mammalian Genome, 1994
In mammals, male sex determination requires a dominant factor provided by the Y Chromosome (Chr). The SRY gene corresponds to this key factor (Sinclair et al. 1990) and is conserved in mammalian species (Foster et al. 1992). The predicted amino acid sequence of SRY contains a central "high mobility group" domain (HMG-box) characteristic of a wide ...
Payen, E.J., Cotinot, C.Y.
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XLS13A and XLS13B: SRY-related genes of Xenopus laevis

Gene, 1997
SRY-related cDNAs, XLS13A and XLS13B, have been isolated from Xenopus laevis ovary. The cDNAs encode polypeptides of 382 and 375 amino acids, respectively. Nucleotide sequences of the two cDNAs are highly homologous to each other. The type-A and type-B XLS13 proteins, and xSox13 reported previously share an identical high mobility group (HMG) box at ...
Y, Hiraoka, N, Komatsu, Y, Sakai, M, Ogawa, M, Shiozawa, S, Aiso   +5 more
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Development in a 46 XX Boy with Positive SRY Gene

Journal of Pediatric Endocrinology and Metabolism, 1996
We present the case of an 11 year-old boy, who asked for medical attention due to obesity and assumed underdeveloped external genitalia. He did not have genital anomalies, penile length was 5.3 cm, testicular volume 2 ml and pubic hair Tanner stage 1. His bone age was normal for chronological age.
A, Rego, E, Margarit, X, Estivill, M, Regal, R V, García-Mayor   +4 more
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Expression of Sry, the mouse sex determining gene

Development, 1995
ABSTRACT In the mouse, Sry is expressed by germ cells in the adult testis and by somatic cells in the genital ridge. Transcripts in the former exist as circular RNA molecules of 1.23 kb, which are unlikely to be efficiently translated. We have used RNase protection to map the extent of the less abundant Sry transcript in the developing ...
A, Hacker, B, Capel, P, Goodfellow, R, Lovell-Badge   +3 more
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