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KDM6B is a conserved activator at the top of the male sex determination pathway.
DevelopmentDupont SM +3 more
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Sry and Sox9: mammalian testis-determining genes
Cellular and Molecular Life Sciences, 1999Sry is the Y-chromosomal gene that acts as a trigger for male development in mammalian embryos. This gene encodes a high mobility group (HMG) box transcription factor that is known to bind to specific target sequences in DNA and to cause a bend in the chromatin.
Peter Koopman, Koopman P
exaly +6 more sources
Studies on the phylogenetic conservation of the SRY gene
Human Genetics, 1991A probe from a conserved motif of the SRY gene (sex-determining region Y), a prime candidate for the human testis-determinant, was hybridized to DNA from 23 species representing 5 vertebrate classes. Hybridization occurred in species with male or female heterogamety, in species with and without sex chromosomes and in those with temperature sex ...
T R, Tiersch +2 more
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SRY-related genes in Xenopus oocytes
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1996SRY-related genes are known as Sox (Sry-box) genes. Two Sox cDNAs from Xenopus oocytes were analyzed. The deduced product of the Xenopus Sox gene (xSox-11) consisted of the standard domains of an HMG box, glycine/alanine-rich region and glutamic acid/aspartic acid-rich region and may be involved in the control of transcription. The other Sox gene (xSox-
S, Miyata, K, Miyashita, Y, Hosoyama
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Regulation of tyrosine hydroxylase gene transcription by Sry
Neuroscience Letters, 2004Testes determining factor Sry is encoded by the Sry locus on the Y chromosome and may be involved in the regulation of blood pressure. Here we tested the hypothesis that Sry regulates transcription of tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamines. Sry was found to be expressed in catecholaminergic regions, in
Amy, Milsted +5 more
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Detection of the SRY gene in patients with Turner Syndrome
Journal of Gynecology Obstetrics and Human Reproduction, 2019If turner syndrome (TS) patients have a Y-containing cell line, they have an increased risk for gonadal tumors. TS patients are therefore screened for Y-chromosome and Y-specific sequences, such as SRY, DYZ1, DYZ3, DYS132, ZFY, TSPY, etc. In addition, since the dysgenetic gonad may include the stroma and granulosa/sertoli cells, which produce androgens,
Erdal, Kurnaz +3 more
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Widespread expression of the testis–determining gene SRY in a marsupial
Nature Genetics, 1995There is compelling evidence from mutation analysis and transgenesis that the SRY gene isolated from human and mouse encodes the testis-determining factor on the mammalian Y chromosome. However, how SRY achieves this function is unclear. Although marsupials have been separated from eutherian mammals for approximately 100 million years, homologues of ...
Harry, Jenny L. +4 more
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Trends in Endocrinology & Metabolism, 1993
SRY was identified in an attempt to clone the mammalian testisdetermining factor. Evidence in the form of sex-reversing mutations and mouse transgenesis experiments indicates that SRY is the testis-determining factor. The cloning of this gene marks the end of the beginning of our understanding of sex determination.
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SRY was identified in an attempt to clone the mammalian testisdetermining factor. Evidence in the form of sex-reversing mutations and mouse transgenesis experiments indicates that SRY is the testis-determining factor. The cloning of this gene marks the end of the beginning of our understanding of sex determination.
openaire +2 more sources