Results 131 to 140 of about 2,083,424 (186)

Regulation of male sexual development by Sry and Sox9

, 2001
Sry, a gene from the Y chromosome, is known to initiate testis formation and subsequent male differentiation in mammals. A related gene, Sox9, also plays a critical role in testis determination, possibly in all vertebrates.
Bowles, J., Bullejos, M., Koopman, P., Monica Bullejos, Peter Koopman, Jo Bowles   +5 more
core   +1 more source

High‐Density Dynamic Culture of Neonatal Porcine Islets Improves Islet Recovery and Function Post‐Transplantation

Xenotransplantation, Volume 33, Issue 6, November/December 2026.
ABSTRACT Introduction Type 1 diabetes (T1D) results from autoimmune destruction of pancreatic β‐cells, necessitating lifelong exogenous insulin therapy. Scalable β‐cell replacement strategies are needed to reproducibly increase ß cell production. Neonatal porcine islets (NPIs) are a promising xenogeneic source of ß cells; however, limited manufacturing
Summer A. Helmi, Chelsea Castro, Soren Stachniak, Arghyadip Bose, Abby Basiuk, Mandy Rosko, Andrew R. Pepper, Gregory S. Korbutt   +7 more
wiley   +1 more source

SRY, SOX9, and DAX1 expression patterns during human sex determination and gonadal development

SRY, SOX9, and DAX1 are key genes in human sex determination, by virtue of their associated male-to-female sex reversal phenotypes when mutated (SRY, SOX9) or over-expressed (DAX1).
Lindsay S; Ball SG; Strachan T; Hagan DM; Hanley NA; Clement-Jones M; Bullen P; Ostrer H; Wilson DI; Salas-Cortes L; McElreavey K; Robson S
core   +4 more sources

A conserved family of genes related to the testis determining gene,SRY

Nucleic Acids Research, 1992
P, Denny, S, Swift, N, Brand, N, Dabhade, P, Barton, A, Ashworth   +5 more
openaire   +3 more sources

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Sry and Sox9: Mammalian Testis-Determining Genes

Cellular and Molecular Life Sciences, 1999
Sry is the Y-chromosomal gene that acts as a trigger for male development in mammalian embryos. This gene encodes a high mobility group (HMG) box transcription factor that is known to bind to specific target sequences in DNA and to cause a bend in the chromatin.
Peter Koopman
exaly   +6 more sources

Regulation of Tyrosine Hydroxylase Gene Transcription by Sry

Neuroscience Letters, 2004
Testes determining factor Sry is encoded by the Sry locus on the Y chromosome and may be involved in the regulation of blood pressure. Here we tested the hypothesis that Sry regulates transcription of tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamines. Sry was found to be expressed in catecholaminergic regions, in
Esther L Sabban, Monte Turner, Gail Dunphy   +2 more
exaly   +3 more sources

Studies on the phylogenetic conservation of the SRY gene

Human Genetics, 1991
A probe from a conserved motif of the SRY gene (sex-determining region Y), a prime candidate for the human testis-determinant, was hybridized to DNA from 23 species representing 5 vertebrate classes. Hybridization occurred in species with male or female heterogamety, in species with and without sex chromosomes and in those with temperature sex ...
T R, Tiersch, M J, Mitchell, S S, Wachtel   +2 more
openaire   +2 more sources

SRY-related genes in Xenopus oocytes

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1996
SRY-related genes are known as Sox (Sry-box) genes. Two Sox cDNAs from Xenopus oocytes were analyzed. The deduced product of the Xenopus Sox gene (xSox-11) consisted of the standard domains of an HMG box, glycine/alanine-rich region and glutamic acid/aspartic acid-rich region and may be involved in the control of transcription. The other Sox gene (xSox-
S, Miyata, K, Miyashita, Y, Hosoyama
openaire   +2 more sources

Detection of the SRY gene in patients with Turner Syndrome

Journal of Gynecology Obstetrics and Human Reproduction, 2019
If turner syndrome (TS) patients have a Y-containing cell line, they have an increased risk for gonadal tumors. TS patients are therefore screened for Y-chromosome and Y-specific sequences, such as SRY, DYZ1, DYZ3, DYS132, ZFY, TSPY, etc. In addition, since the dysgenetic gonad may include the stroma and granulosa/sertoli cells, which produce androgens,
Erdal, Kurnaz, Semra, Çetinkaya, Şenay, Savaş-Erdeve, Zehra, Aycan   +3 more
openaire   +2 more sources

Widespread expression of the testis–determining gene SRY in a marsupial

Nature Genetics, 1995
There is compelling evidence from mutation analysis and transgenesis that the SRY gene isolated from human and mouse encodes the testis-determining factor on the mammalian Y chromosome. However, how SRY achieves this function is unclear. Although marsupials have been separated from eutherian mammals for approximately 100 million years, homologues of ...
Harry, Jenny L., Koopman, Peter, Brennan, Francine E., Graves, Jennifer A., Renfree, Marilyn B.   +4 more
openaire   +5 more sources