Results 111 to 120 of about 39,114 (250)

PRDM1 Knockdown Promotes Ferroptosis and Sunitinib Sensitivity by Modulating the PI3K/Akt Signaling Through Inhibition of ESM1 Transcription in Renal Cell Carcinoma

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Renal cell carcinoma (RCC) is a commonly occurring and considerable burden on public health. Although chemotherapy benefits patients with advanced RCC, sunitinib resistance leads to a poor prognosis. Ferroptosis is also involved in sunitinib resistance in RCC.
Yi‐Shuai Zhang, Xin‐Qi Pei, Ji‐Ping Sun, Chen‐Hui Ma, Xin‐Yang Wang, Xu‐Dong Li   +5 more
wiley   +1 more source

CARACTERIZACIÓN MOLECULAR DE DOS PACIENTES 46 XY, FENOTIPO FEMENINO. SÍNDROME DE SWYER

Archivo Médico de Camagüey, 2004
El síndrome de Swyer es un desorden de la diferenciación sexual en el cual los pacientes exhiben un fenotipo femenino con cariotipo 46 XY e hipoplasia gonadal sin células germinales.
Juan Carlos Piña Napal, Charles T. Vázquez Drake, Hilda Granda Ibarra, Blanca Suardíaz Martínez   +3 more
doaj  

Testicular differentiation occurs in absence of R-spondin1 and Sox9 in mouse sex reversals.

PLoS Genetics, 2012
In mammals, male sex determination is governed by SRY-dependent activation of Sox9, whereas female development involves R-spondin1 (RSPO1), an activator of the WNT/beta-catenin signaling pathway. Genetic analyses in mice have demonstrated Sry and Sox9 to
Rowena Lavery, Anne-Amandine Chassot, Eva Pauper, Elodie P Gregoire, Muriel Klopfenstein, Dirk G de Rooij, Manuel Mark, Andreas Schedl, Norbert B Ghyselinck, Marie-Christine Chaboissier   +9 more
doaj   +1 more source

Sexual dimorphism in cancer. [PDF]

, 2016
The incidence of many types of cancer arising in organs with non-reproductive functions is significantly higher in male populations than in female populations, with associated differences in survival.
A Gabory, A Hewagama, A Minajigi, A Mode, A Schroeder, A Sottoriva, A Sugathan, A Vigano, AB Hui, AJ Templeton, AM Di Bisceglie, AN Schmidt, Andrea Clocchiatti, AS Dobs, B Rondinelli, BG Mar, BM Nugent, BR Migeon, C Brisken, C le Sage, C Patrone, C Pequeux, C Tomasetti, CC Whitacre, CK Huang, CL Bennett, CM Fillmore, CP Yu, CR Scoggins, D Nakada, D Ohlund, DA Leach, DJ Tsuei, DJ Tsuei, DP Sieveking, DW Bellott, DW Wu, E Yildirim, EE Calle, Elisa Cora, EM Jacobson, EN Fish, F Mauvais-Jarvis, G Pinton, G Robinson, G van Haaften, G. Paolo Dotto, GJ Shim, GL Dalgliesh, GP Dotto, GR Sareddy, GS Ashcroft, H Hamada, H Masuda, H Matsuoka, H von Boehmer, HG Jorgensen, HJ Han, HJ Hartwell, I Bianchi, I Dokal, I Fadl-Elmula, I Martincorena, I Mertens-Walker, I Paterni, I Porsch Hallstrom, J Bain, J Cai, J Collignon, J Ferlay, J Hartman, J Hartman, J Herrington, J Kowalski, J Nie, J Van der Meulen, JA den Boon, JA Sloan, JA Stanley, JD Potter, JG Markle, JJ Konig, JJ Lai, JJ Lai, JL Pawluski, JP Dumanski, JP Wisnivesky, JR Kerrigan, K De Keersmaecker, K Kato, K Sarma, K Skjefstad, K Strehlow, K Yakimchuk, KH Seo, KM Mueller, KP Lai, L Bottarelli, L Campbell, L Campbell, L Jiang, L Wen, L Yurkovetskiy, LA Forsberg, LA Torre, LJ Walport, LM Merlo, LY Fang, M Matic, M Melé, M Nadal, M Stoner, M Walecki, ME Taplin, MH Benoit, MJ Fullwood, MJ Polanczyk, MJ Thornton, MJ Tisdale, ML Delbridge, ML Lee, MN Passarelli, MS Simon, MT Dorak, N Ahuja, NO Bianchi, O Wada-Hiraike, OA Press, P Ntziachristos, P Sharma, P Van Vlierberghe, PA Northcott, PB Gupta, PF Cosper, PR Stahl, PY OuYang, R Bacchetta, R Dai, R Gatenby, R Liu, R Liu, R Rahbari, R Singhal, R Yamamoto, R Yamamoto, RD Cardiff, RL Siegel, RP Barros, RT Calado, RT Calado, RW Lea, S Basaria, S Bayne, S Boumahdi, S Hinz, S Li, S Murakami, S Murakami, S Singh, S Slavin, S von Haehling, S Yoshida, SJ Ellem, SJ McPherson, SN Austad, T Kawakami, T Kawakami, T Kido, T Kido, T Kido, T Kido, T Matsumoto, U Berger, V Huff, V Karanikas, VE Baracos, W Yang, WE Naugler, WS Garrett, X Li, X Yuan, XO Yang, Y Wang, Y Yao, Y Zhang, YF Lau, YF Lau, Yosra Zhang, YS Brooks, Z Li, Z Li   +190 more
core   +1 more source

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, EarlyView.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source

Regulation of CATSPER1 expression by the testis-determining gene SRY

PLOS ONE, 2018
El gen CATSPER1 codifica una subunidad formadora de poros y sensible al pH del canal permeable CatSper Ca2+, una proteína en el flagelo esencial para la hiperactivación de los espermatozoides. Estudios previos han demostrado que el promotor del gen Catsper1 murino está regulado por diferentes proteínas Sox.
Aleida Olivares, Adriana Hernández-Reyes, Ricardo Felix, Ángela Forero, Minerva Mata‐Rocha, Javier Hernández‐Sánchez, Ivanaldo Santos, Charmina Aguirre-Alvarado, Norma Oviedo   +8 more
openaire   +4 more sources

Transcriptomic comparative study between canalicular adenoma and HMGA2::WIF1 canalicular‐like pleomorphic adenoma

The Journal of Pathology, EarlyView.
Abstract Canalicular adenoma (CA) is a benign salivary gland tumor predominantly affecting the upper lip and is characterized by monomorphic epithelial cells arranged in branching cords within a loose and vascularized stroma. Unlike pleomorphic adenoma (PA), CA lacks a chondroid matrix and exhibits specific histological features, such as high cuboidal ...
Ziyad Alsugair, Anne Champagnac, Maxime Fieux, Pierre Philouze, Philippe Ceruse, Brice Thamphya, Daniel Pissaloux, Franck Tirode, Nazim Benzerdjeb   +8 more
wiley   +1 more source

Monitoring of transplanted liver health by quantification of organ-specific genomic marker in circulating DNA from receptor.

PLoS ONE, 2014
BackgroundHealth assessment of the transplanted organ is very important due to the relationship of long-term survival of organ transplant recipients and health organ maintenance.
Hada C Macher, Gonzalo Suárez-Artacho, Juan M Guerrero, Miguel A Gómez-Bravo, Sara Álvarez-Gómez, Carmen Bernal-Bellido, Inmaculada Dominguez-Pascual, Amalia Rubio   +7 more
doaj   +1 more source

Molecular Targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) within the Zebrafish Ovary: Insights into TCDD-induced Endocrine Disruption and Reproductive Toxicity [PDF]

, 2008
TCDD is a reproductive toxicant and endocrine disruptor, yet the mechanisms by which it causes these reproductive alterations are not fully understood.
Carvan, Michael J., III, Hessner, Martin J., Hutz, Reinhold J., King Heiden, Tisha C., Rise, Matthew L., Struble, Craig   +5 more
core   +1 more source

DNA bending and orientation-dependent function of YY1 in the c-fos promoter [PDF]

, 1993
The assembly of multicomponent complexes at promoters, enhancers, and silencers likely entails perturbations in the path of the DNA helix. We present evidence that YY1, a ubiquitously expressed DNA-binding protein, regulates the activity of the c-fos ...
Gilman, M. Z., Natesan, S.
core   +1 more source