Results 111 to 120 of about 1,694,828 (235)

NG2‐Glia in Central Nervous System Following Injury: From Pathological Involvement to Repair Potential

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Following CNS injury, NG2‐glia display distinct functional phases. In the early stage, NG2‐glia are rapidly activated, proliferate, migrate to the lesion site and secrete CSPGs, which form a chemical and physical barrier that inhibits axonal regeneration.
Yunyun Cai, Xin Shen, Ming Li, Junjie Li, Gang Chen   +4 more
wiley   +1 more source

Reproducibility of Serum Androgen Concentrations by Liquid Chromatography Mass Spectrometry in Healthy Male and Female Athletes

Drug Testing and Analysis, Volume 18, Issue 9, Page 1220-1224, September 2026.
Box and whiskers plots show the distributions of serum testosterone (T), dihydrotestosterone (DHT), androstenedione (A4), and the ratios of T/FDHT and T/A4. ABSTRACT Detection of androgen doping relies on mass spectrometry‐based methods to detect natural endogenous and exogenous androgens in urine and serum. To distinguish exogenous administration from
D. J. Handelsman, S. Bermon
wiley   +1 more source

Up-regulation of SOX9 in human sex-determining region on the Y chromosome (SRY)-negative XX males

, 2008
Background In mammals, gonadal sex is normally determined by the presence or absence of the Y chromosome gene SRY. After expression of SRY in the sexually indifferent gonad, a number of genes encoding transcription factors and growth factors implicated ...
Kojima, Yoshiyuki, Kohri, Kenjiro, Morohashi, Ken-Ichiro, Koopman, Peter, Sasaki, Shoichi, Fukui, Yuko, Mizuno, Kentaro, Hayashi, Yutaro   +7 more
core   +1 more source

Complete male-to-female sex reversal in XY mice lacking the miR-17~92 cluster

Nature Communications
Mammalian sex determination is controlled by antagonistic gene cascades operating in embryonic undifferentiated gonads. The expression of the Y-linked gene SRY is sufficient to trigger the testicular pathway, whereas its absence in XX embryos leads to ...
Alicia Hurtado, Irene Mota-Gómez, Miguel Lao, Francisca M. Real, Johanna Jedamzick, Miguel Burgos, Darío G. Lupiáñez, Rafael Jiménez, Francisco J. Barrionuevo   +8 more
doaj   +1 more source

Gonadotropin Suppression During Mini‐Puberty as an Early Biomarker of Classic 21‐Hydroxylase Deficiency

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
To prevent life‐threatening adrenal crisis and to help perform appropriate sex assignment in affected female patients, newborn screening for 21‐hydroxylase deficiency (21OHD) relies on 17‐hydroxyprogesterone but has a high false‐positive rate. Neonatal LH and FSH suppression during mini‐puberty clearly distinguished classic 21OHD from non‐classic and ...
Ryosei Iemura, Yuri Suzuki, Maki Gau, Ryuta Orimoto, Haruki Yamano, Hisae Nakatani, Shizuka Kirino, Yoko Saito, Eriko Adachi, Atsumi Tsuji‐Hosokawa, Kenichi Kashimada, Kei Takasawa   +11 more
wiley   +1 more source

Variants in SRY and NR5A1 Genes in Sri Lankan children with 46, XY disorders of sex development: insights into mutation spectrum and diagnostic potential

Egyptian Journal of Medical Human Genetics
Background 46, XY disorders of sex development (DSD) are clinically and genetically heterogeneous congenital conditions caused by abnormal or incomplete gonadal, genital, or chromosomal development that results in discordant phenotypic sex.
Daniel Sanjeev Ferdinands, Sumadee De Silva, Asanka Sudeshini Hewage, Navoda Atapattu   +3 more
doaj   +1 more source

High incidence of Y‐chromosome mosaicism in male and female individuals with mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy

Epilepsia, Volume 67, Issue 9, Page 4907-4921, September 2026.
Abstract Objective Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is an underrecognized pediatric cortical lesion associated with somatic X‐linked SLC35A2 variants in approximately 50% of individuals. The genetic etiology in individuals without detectable SLC35A2 mutations remains undefined, which limits
Erica Cecchini, Till Hartlieb, Ahmed Gaballa, Katja Kobow, Mitali Katoch, Paraskevi Chasani, Georgia Vasileiou, Wiebke Hofer, Lea M. Reisch, Manfred Kudernatsch, Christian G. Bien, Roland Coras, Ingmar Blümcke, Lucas Hoffmann   +13 more
wiley   +1 more source

The rise and fall of SRY

, 2015
Comparisons between species reveal when and how SRY, the testis-determining gene, evolved. SRY is younger than the Y chromosome, and so was probably not the original mammal sex-determining gene that defined the Y.
Graves, Jennifer
core   +1 more source

Early Diagnosis of Fetal Sex and its Relationship to Some Biochemical and Physiological Variables in Pregnant Women in Salah Al-Din Governorate

Proceedings of the International Conference on Applied Innovations in IT
Genes for sex determination are widely analyzed and used to predict fetal sex during different trimesters of pregnancy. However, their correlation with sex prediction based on ultrasound results, as well as with testosterone and estrogen levels in the ...
Noor Lateef Omer, Hussien Mohammad Tayawi   +1 more
doaj   +1 more source

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen, Jiayi Wang, Jimin Yu, Yiran Zhou, Lihai Liu, Jing Liu, Liang Wang   +6 more
wiley   +1 more source