Results 91 to 100 of about 23,557 (205)

Modification of the Transcription Factor FOXL2 at Serines 101 and 107 Disables DNA Binding, Leads to Nucleolar Relocalization, and Rewires Granulosa‐Cell Programs

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
PKC‐mediated phosphorylation of FOXL2 weakens DNA binding, alters subnuclear localization and protein interactions, and reshapes FOXL2‐dependent transcriptional programs in granulosa cells, supporting a reversible mechanism that modulates FOXL2 activity through phosphorylation of its DNA‐binding domain. ABSTRACT FOXL2 is a forkhead transcription factor
Ludovic Mousseron, Despoina Chousianiti, Francis Poulat, Bérangère Legois, Reiner A. Veitia, Anne‐Laure Todeschini   +5 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, Volume 20, Issue 8, Page 1933-1962, August 2026.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Structural Guidance in 3D Microgel‐in‐Hydrogel Systems to Improve Chondrogenesis

Advanced Healthcare Materials, Volume 15, Issue 29, 7 August 2026.
The Anisogel, an anisotropic microgel‐in‐hydrogel system, guides chondrogenic differentiation of human mesenchymal stromal cells (hMSCs) modulated by the alignment and size of anisometric microgels. Chondrogenic markers are upregulated in an in vitro model and guided tissue infiltration is enhanced in a semi‐orthopedic mouse model due to the physico ...
Julia Kamp, Alisa C. Suturin, Claudia A. Garrido, Xiaole Tong, Jietao Xu, Nicole Kops, Lea‐Sophie Müller, Till Hülsmann, Abdolrahman Omidinia‐Anarkoli, Laura Klasen, Tamás Haraszti, Gerjo J. V. M. van Osch, Laura De Laporte   +12 more
wiley   +1 more source

Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis

Advanced Science, Volume 13, Issue 43, 3 August 2026.
Stage‐specific succinylation of histone H3 at lysine 14 and 23 differentially controls insect metamorphosis and oogenesis through distinct GPCR‐PKC signaling cascades, revealing an evolutionarily conserved epigenetic mechanism that coordinates key life‐history traits.
Yu‐Pu Jing, Lunjie Li, Libin Yang, Lin‐Jie Zhang, Qiang Yan, Ci Zhang, Zanrong Wen, Guangze Yu, Qian Li, Shutang Zhou   +9 more
wiley   +1 more source

Variants in SRY and NR5A1 Genes in Sri Lankan children with 46, XY disorders of sex development: insights into mutation spectrum and diagnostic potential

Egyptian Journal of Medical Human Genetics
Background 46, XY disorders of sex development (DSD) are clinically and genetically heterogeneous congenital conditions caused by abnormal or incomplete gonadal, genital, or chromosomal development that results in discordant phenotypic sex.
Daniel Sanjeev Ferdinands, Sumadee De Silva, Asanka Sudeshini Hewage, Navoda Atapattu   +3 more
doaj   +1 more source

Innate Immune Cells in Non‐Small Cell Lung Cancer: Roles in Tumor Progression and Therapeutic Responses

Cancer Innovation, Volume 5, Issue 4, August 2026.
Innate immune cells (IICs) are not only as first‐line defenders or simple auxiliaries to adaptive immunity, but also as decisive regulators of non‐small cell lung cancer progression and treatment outcomes. ABSTRACT As a leading cause of cancer‐related morbidity and mortality worldwide, non‐small cell lung cancer (NSCLC) is profoundly influenced by ...
Jiaxin Liu, Jie Jia, Chong Wang, Zongru Zhou, Zhuoyu Cheng, Ziyi Zhang, Xueyi Jiang, Ziyu Huang, Chunyan Li   +8 more
wiley   +1 more source

Complete male-to-female sex reversal in XY mice lacking the miR-17~92 cluster

Nature Communications
Mammalian sex determination is controlled by antagonistic gene cascades operating in embryonic undifferentiated gonads. The expression of the Y-linked gene SRY is sufficient to trigger the testicular pathway, whereas its absence in XX embryos leads to ...
Alicia Hurtado, Irene Mota-Gómez, Miguel Lao, Francisca M. Real, Johanna Jedamzick, Miguel Burgos, Darío G. Lupiáñez, Rafael Jiménez, Francisco J. Barrionuevo   +8 more
doaj   +1 more source

Spatio‐Temporal Dynamics of Macroglial Cell Organization and Proximity to Blood Vessels During Postnatal Development

International Journal of Developmental Neuroscience, Volume 86, Issue 5, August 2026.
From P5, Sox9+ cells are evenly distributed, unlike Sox10+ cells. From P15, Sox9+ cells are located closer to blood vessels than Sox10+ cells. Distribution of astrocytes is not altered in Mlc1 KO cortex. ABSTRACT Brain cortical development results from the proliferation, differentiation, migration and maturation of many cell types.
Naomie Guille, Héloïse Monnet, Tristan Hourcade, Philippe Mailly, Martine Cohen‐Salmon, Anne‐Cécile Boulay   +5 more
wiley   +1 more source

Early Diagnosis of Fetal Sex and its Relationship to Some Biochemical and Physiological Variables in Pregnant Women in Salah Al-Din Governorate

Proceedings of the International Conference on Applied Innovations in IT
Genes for sex determination are widely analyzed and used to predict fetal sex during different trimesters of pregnancy. However, their correlation with sex prediction based on ultrasound results, as well as with testosterone and estrogen levels in the ...
Noor Lateef Omer, Hussien Mohammad Tayawi   +1 more
doaj   +1 more source

EphA2/SHP2/SOX8 Axis: A Novel Target for Regulation of Migration and Cetuximab Treatment Sensitivity in Oral Squamous Cell Carcinoma

Molecular Carcinogenesis, Volume 65, Issue 8, Page 977-988, August 2026.
ABSTRACT The development of resistance to anticancer therapies in cancer cell is a major challenge in the treatment of oral squamous cell carcinoma (OSCC), a common malignant tumor. Erythropoietin‐producing hepatocellular A2 (EphA2) affects several cancers, and this study examined its role in enhancing OSCC.
Dayong Yan, Lele Guo, Fei Pei, Ketao Zhong   +3 more
wiley   +1 more source