Results 81 to 90 of about 39,114 (250)

Foxl2 gene and the development of the ovary : a story about goat, mouse, fish and woman [PDF]

, 2005
In this review, we describe recent results concerning the genetics of sex determination in mammals. Particularly, we developed the study of the FOXL2 gene and its implication in genetic anomalies in goats (PIS mutation) and humans (BPES).
Baron, Daniel, Batista, Frank, Chaffaux, Stéphane, Cocquet, Julie, Cotinot, Corinne, Cribiu, Edmond, De Baere, Elfride, Fellous, Marc, Guiguen, Yann, Jaubert, Francis, Pailhoux, Eric, Pannetier, Maëlle, Vaiman, Daniel, Veitia, Reiner, Vigier, Bernard   +14 more
core   +4 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

A case report of an XX male with complete masculinization but absence of the SRY gene

Middle East Fertility Society Journal, 2010
A 34-year old man with complete masculinization and a history of several years of infertility was referred to us for genetic reviewing. His semen analysis showed azoospermia.
Ghalia Abou Alchamat, Marwan Alhlabi, Muhyiddin Issa   +2 more
doaj   +1 more source

TALEN-mediated editing of the mouse Y chromosome [PDF]

, 2013
The functional study of Y chromosome genes has been hindered by a lack of mouse models with specific Y chromosome mutations. We used transcription activator-like effector nuclease (TALEN)-mediated gene editing in mouse embryonic stem cells (mESCs) to ...
A Mayer, Adam J Bogdanove, Albert W Cheng, Chikdu S Shivalila, D Pirottin, Daniel B Dadon, Daniel F Voytas, David C Page, DY Guschin, G Grant Welstead, GG Welstead, H Skaletsky, Haoyi Wang, J Rohozinski, JC Miller, JF Hughes, KB Shpargel, LL Washburn, MJ Moscou, P Koopman, R Lovell-Badge, Rudolf Jaenisch, S Mazeyrat, Styliani Markoulaki, T Cermak, Tatyana Pyntikova, Yueh-Chiang Hu   +26 more
core   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

Organizational and functional status of the Y-linked genes and loci in the infertile patients having normal spermiogram. [PDF]

PLoS ONE, 2012
Male fertility is an orchestrated interplay of loci on the Y chromosome with a number of genes from across the other chromosomes. In this context, micro-deletions in the Y chromosome have been correlated with spermatogenic failure often leading to ...
Anju Kumari, Sandeep Kumar Yadav, Sher Ali   +2 more
doaj   +1 more source

Essential gene pathways for glioblastoma stem cells: clinical implications for prevention of tumor recurrence. [PDF]

, 2011
Glioblastoma (World Health Organization/WHO grade IV) is the most common and most aggressive adult glial tumor. Patients with glioblastoma, despite being treated with gross total resection and post-operative radiation/chemotherapy, will almost always ...
Choe, Jinny, Liau, Linda M, Liu, Yue, Tso, Cho-Lea, Tso, Jonathan, Yamada, Kazunari, Ye, Fei   +6 more
core   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Amplification of Porcine SRY Gene for Sex Determination

Asian-Australasian Journal of Animal Sciences, 2009
The separation of X and Y chromosome-bearing sperm is of use in many aspects of livestock maintenance. In this study, we sought to determine the difference in DNA content between X- and Y-bearing sperm, separate sperm into X- and Y-enriched pools, and assess the efficacy of sorting.
S. G. Choi, M. S. Bae, E. S. Lee, S. O. Kim, B. K. Kim, J. H. Yang, C. E. Jeon, H. H. Kim, Y. J. Hwang, E. S. Lee, D. Y. Kim   +10 more
openaire   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source