Results 81 to 90 of about 2,083,424 (186)
Mogroside V Promotes Brown Adipose Thermogenesis via FTO‐m6A‐LETMD1‐UCP1 Pathway to Combat Obesity
Phytotherapy Research, EarlyView.Mogroside V (MV) alleviates high‐fat diet‐induced obesity and metabolic dysfunction. Mechanistically, MV suppresses FTO expression, thereby increasing m6A modification of Letmd1 mRNA and enhancing its YTHDC2‐dependent stabilization. Theincreased LETMD1 expression is associated with elevated PGC1α and UCP1 levels, contributing to brown adipocyte ...
Yuan‐hai Sun +5 more
wiley +1 more source
Analysis of Sry Duplications On the Rattus Norvegicus Y-Chromosome [PDF]
, 2013 Background: Gene copy number variation plays a large role in the evolution of genomes. In Rattus norvegicus and other rodent species, the Y-chromosome has accumulated multiple copies of Sry loci.
Scott, Sarah +7 more
core
Phytotherapy Research, EarlyView.Proposed mechanism by which notoginsenoside R2 (NGR2) attenuates renal interstitial fibrosis. In injured renal tubular epithelial cells, CASP2 downregulation and enhanced ubiquitin‐dependent degradation of ALDH3A1 disrupt mitochondria‐associated endoplasmic reticulum membranes (MAMs) and impair fatty acid oxidation (FAO), leading to lipid accumulation ...
Guanting Chen +10 more
wiley +1 more source
SRY Directly Regulates the Neurotrophin 3 Promoter During Male Sex Determination and Testis Development in Rats1 [PDF]
, 2011 Neurotrophin 3 (Ntf3) is expressed in Sertoli cells and acts as a chemo-attractant for cell migration from the mesonephros into the developing testis, a process critical to the early morphological events of testis cord formation. The male sex-determining
BHANDARI, Ramji K +7 more
core +1 more source
Oestrogen blocks the nuclear entry of SOX9 in the developing gonad of a marsupial mammal
BMC Biology, 2010 Background Hormones are critical for early gonadal development in nonmammalian vertebrates, and oestrogen is required for normal ovarian development.
Pask Andrew J +4 more
doaj +1 more source
Small, EarlyView.Biomaterial platforms can control where and when mRNA‐encoded proteins are expressed to support tissue repair. This Review proposes a cargo–target–timing framework linking therapeutic function, target tissues and cells, and expression profiles with carrier and scaffold design.
Huachun Pan +14 more
wiley +1 more source
Prenatal Diagnosis of 45,X/46,XX Mosaicism with Presence of SRY Gene. A Case Report
Medisur, 2013 The most common karyotype of the Turner syndrome is 45,X, although it may occur as mosaic 45,X/46,XX. In the Provincial Medical Genetics Center, a 42-year-old pregnant woman underwent an amniocentesis which led to the detection of mosaic Turner Syndrome (
Pedro Alí Díaz-Véliz Jiménez +3 more
doaj +2 more sources
Sex-Dependent Gene Expression in Human Pluripotent Stem Cells
Cell Reports, 2014 Males and females have a variety of sexually dimorphic traits, most of which result from hormonal differences. However, differences between male and female embryos initiate very early in development, before hormonal influence begins, suggesting the ...
Daniel Ronen, Nissim Benvenisty
doaj +1 more source
Small Methods, EarlyView.We developed a 3D‐printed nerve interface integrating a biomimetic nanocomposite hydrogel with sustained delivery of thermostable FGF‐2. The bioactive interface supports Schwann cell activity and myelination while providing a regenerative microenvironment.
Diego N. Rodriguez‐Sanchez +10 more
wiley +1 more source
Copy Number Variations of Four Y-Linked Genes in Swamp Buffaloes
Animals, 2019 Copy number variation (CNV), a significant source of genetic diversity in the mammalian Y chromosome, is associated with the development of many complex phenotypes, such as spermatogenesis and male fertility.
Ting Sun +4 more
doaj +1 more source