Results 71 to 80 of about 2,083,424 (186)

Effects of Transfected Human and Mouse SRY/Sry Genes upon the Expression of Hypothetical SRY-Cascade Genes in Cultured Mouse Sertoli Cell Line, TM-4.

Journal of Reproduction and Development, 1996
In mammals, the SRY (the sex determining region on the Y; Sry in the mouse) gene is responsible for the function of TDF (testis determining factor; Tdy in the mouse) locus, and plays a key role in the sex determination. In the mouse, the Sry open reading frame (ORF) is flanked at either end by a large inverted repeat, causing the formation of ...
HIROTA, Osamu, NISHINO, Koichiro, TOYOOKA, Yayoi, KODAMA, Terutaka, TANAKA, Satoshi, YAMANOUCHI, Keitaro, TOJO, Hideaki, TACHI, Chikashi   +7 more
openaire   +2 more sources

The cerebellin 4 precursor gene is a direct target of SRY and SOX9 in mice

, 2009
In most mammals, the expression of SRY (sex-determining region on the Y chromosome) initiates the development of testes, and thus determines the sex of the individual. However, despite the pivotal role of SRY, its mechanism of action remains elusive. One
Sinclair, A, Schedl, A, Wilhelm, Dagmar, Bradford, S. T., Schedl, Andreas, Maddugoda, Madhavi, P, Chaboissier, M. C., Harley, Vincent, Maddugoda, M. P., Chaboissier, Marie-Christine, Koopman, P, Harley, V, Hiramatsu, R, Wilhelm, D, Bradford, Stephen, T, Kanai, Yoshiakira, Koopman, Peter, Bernard, P, Kanai, Y, Hiramatsu, Ryuji, Bernard, Pascal, Sinclair, Andrew   +21 more
core   +1 more source

PCR amplification of SRY-related gene sequences reveals evolutionary conservation of the SRY-box motif. [PDF]

Genome Research, 1993
SRY (sex-determining region of the Y chromosome) has recently been identified as a key regulatory gene in mammalian sex determination. The open reading frame of this gene contains an 80-amino-acid motif, the SRY-box, which shares a high degree of homology with a DNA-binding domain found in the high-mobility-group (HMG) proteins HMG1 and HMG2.
A M, Coriat, U, Müller, J L, Harry, D, Uwanogho, P T, Sharpe   +4 more
openaire   +2 more sources

Validation of the WID‐CIN Methylation Test for Detection of Cervical Intraepithelial Neoplasia Grade 3 or Worse in an Independent Cohort

International Journal of Cancer, EarlyView.
ABSTRACT Many cervical screening programmes rely on cytology for triage of high‐risk human papillomavirus (hrHPV) positive women. However, cytological triage has variable and often limited sensitivity, and its availability can be restricted in resource‐poor settings.
Laura Burney Ellis, Sarah J. Bowden, Jack Tighe, Muhammad Habiburrahman, Katerina‐Vanessa Savva, Maria Paraskevaidi, Maria Nasioutziki, Chris J. Peters, James M. Flanagan, Maria Kyrgiou   +9 more
wiley   +1 more source

Analysis of the role of Amh and Fra1 in the Sry regulatory pathway

, 1996
Sry is the Y-chromosomal gene responsible for initiating the pathway of male development in mammals, presumably by regulating downstream target genes. As a basis for examining the role played by Sry and other candidate sex-determining genes, we have used
Schultz, Richard M., Corrales, M., Cohen, Donna R., Mishina, Yuji, Behringer, Richard R., Koopman, Peter, Lalwani, S., Brison, Daniel R., Huszar, G., Jeske, Yvette W. A., Sayme, N., Vigue, L.   +11 more
core   +1 more source

A rainbow trout SRY‐type gene expressed in pituitary glands

FEBS Letters, 1995
A Sox (SRY‐type HMG box) gene, designated SoxP1, was isolated from a cDNA library made from pituitaries of immature rainbow trout. Sequence analysis indicated that the cDNA had an open reading frame encoding 467 amino acid residues containing a DNA binding motif, known as the high mobility group (HMG) box. Northern blot analysis showed trout SoxP1 mRNA
Ito, Michihiko, Ishikawa, Masako, Suzuki, Shin, Takamatsu, Nobuhiko, Shiba, Tadayoshi   +4 more
openaire   +2 more sources

Developmental and Behavioral Effects of Arsenobetaine in Zebrafish (Danio rerio)

Journal of Applied Toxicology, EarlyView.
ABSTRACT Arsenobetaine (AsB) is a prevalent organoarsenical in aquatic environments and is generally regarded as nontoxic. Despite its widespread occurrence, the developmental and neurobehavioral toxicity of AsB has not been systematically investigated.
Sravan Kumar Putnala, Prerita Sharma, Prannav Jain, Samira Leila Baldin, Owen Luo, A. K. M. Munzurul Hasan, Md Helal Uddin, Mahesh Rachamalla, Som Niyogi   +8 more
wiley   +1 more source

Male-biased distribution of the human Y chromosomal genes SRY and ZFY in the lizard Calotes versicolor, which lacks sex chromosomes and temperature-dependent sex determination

, 1997
In the present investigation on the lizard Calotes versicolor, which lacks temperature-dependent sex determination, all the conventional cytological techniques used failed to resolve a distinguishable pair of sex chromosomes.
Mohanty, Jayashree, Ganesh, Subramaniam, Raman, Rajiva, Subramaniam Ganesh, Rajiva Raman, Jayashree Mohanty   +5 more
core   +1 more source

Prevention of Early Onset of Breast Cancer With Ashwagandha

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm, Su‐Hyeong Kim, Shivendra V. Singh   +2 more
wiley   +1 more source

Amplification of Porcine SRY Gene for Sex Determination

Asian-Australasian Journal of Animal Sciences, 2009
The separation of X and Y chromosome-bearing sperm is of use in many aspects of livestock maintenance. In this study, we sought to determine the difference in DNA content between X- and Y-bearing sperm, separate sperm into X- and Y-enriched pools, and assess the efficacy of sorting.
S. G. Choi, M. S. Bae, E. S. Lee, S. O. Kim, B. K. Kim, J. H. Yang, C. E. Jeon, H. H. Kim, Y. J. Hwang, E. S. Lee, D. Y. Kim   +10 more
openaire   +1 more source