Results 121 to 130 of about 1,694,828 (235)

Classification of High‐ and Low‐Risk Patients With Dermal Leiomyosarcoma: An Exploratory Nationwide Cohort Study

Journal of Surgical Oncology, Volume 134, Issue 3, Page 394-402, September 2026.
ABSTRACT Background Risk factors for dermal leiomyosarcoma (dLMS) metastasis remain poorly defined because methodological constraints, small sample sizes, and short follow‐up have limited previous studies. Objectives To investigate risk factors for metastasis and local recurrence, and to propose a high‐ and low‐risk classification for dLMS. Methods All
Kiya Abebe, Anders Munch, Anne Lene Wagenblast, Grethe Schmidt, David Hebbelstrup Jensen, Michael M. Petersen, Anand C. Loya, Søren Daugaard, Thomas Mentzel, Mikkel Herly, Peter Vester‐Glowinski, Mathias Ørholt   +11 more
wiley   +1 more source

The cerebellin 4 precursor gene is a direct target of SRY and SOX9 in mice

, 2009
In most mammals, the expression of SRY (sex-determining region on the Y chromosome) initiates the development of testes, and thus determines the sex of the individual. However, despite the pivotal role of SRY, its mechanism of action remains elusive. One
Sinclair, A, Schedl, A, Wilhelm, Dagmar, Bradford, S. T., Schedl, Andreas, Maddugoda, Madhavi, P, Chaboissier, M. C., Harley, Vincent, Maddugoda, M. P., Chaboissier, Marie-Christine, Koopman, P, Harley, V, Hiramatsu, R, Wilhelm, D, Bradford, Stephen, T, Kanai, Yoshiakira, Koopman, Peter, Bernard, P, Kanai, Y, Hiramatsu, Ryuji, Bernard, Pascal, Sinclair, Andrew   +21 more
core   +1 more source

SRY Gene [PDF]

, 2020
openaire   +1 more source

PRDM1 Knockdown Promotes Ferroptosis and Sunitinib Sensitivity by Modulating the PI3K/Akt Signaling Through Inhibition of ESM1 Transcription in Renal Cell Carcinoma

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.
ABSTRACT Renal cell carcinoma (RCC) is a commonly occurring and considerable burden on public health. Although chemotherapy benefits patients with advanced RCC, sunitinib resistance leads to a poor prognosis. Ferroptosis is also involved in sunitinib resistance in RCC.
Yi‐Shuai Zhang, Xin‐Qi Pei, Ji‐Ping Sun, Chen‐Hui Ma, Xin‐Yang Wang, Xu‐Dong Li   +5 more
wiley   +1 more source

RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley   +1 more source

Genomic Profiling of Anophthalmia/Microphthalmia‐Associated CNVs Reveals Complex Genotype–Phenotype Correlations and Incomplete Penetrance

Molecular Genetics &Genomic Medicine, Volume 14, Issue 9, September 2026.
Genomic profiling of four families with anophthalmia/microphthalmia‐associated copy number variations (CNVs) revealed marked phenotypic variability, including incomplete penetrance of OTX2‐related microphthalmia. These findings highlight the importance of phenotype‐driven interpretation of CNVs beyond standard pathogenicity scoring.
Dong Wu, Mengting Zhang, Qian Zhang, Fengyang Wang, Qiaofang Hou, Hongyan Liu, Shixiu Liao, Hai Xiao   +7 more
wiley   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, Volume 5, Issue 3, Page 241-259, September 2026.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

Preimplantation Genetic Testing for Families at Risk of Haemophilia: Ten‐Year Single‐Centre Experience

Haemophilia, Volume 32, Issue 5, Page 1239-1246, September/October 2026.
ABSTRACT Introduction Preimplantation genetic testing for monogenic diseases (PGT‐M) is a reproductive option for couples at high risk of transmitting inherited disorders. We report a ten‐year single‐centre PGT‐M experience in families at risk of hemophilia.
Mimosa Mortarino, Isabella Garagiola, Valeria Nicotra, Alessandra Riccaboni, Cristina Guarneri, Edgardo Somigliana, Flora Peyvandi   +6 more
wiley   +1 more source

Molecular Mediators Associated With Myelination, Demyelination, and Remyelination in the Peripheral Nervous System

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT The peripheral nervous system (PNS) is responsible for innervating all regions of the body outside of the central nervous system (CNS), the latter consisting of the brain, spinal cord, and optic nerves. While myelin is an essential component for the efficient functioning of both CNS and peripheral nerve cells, it is particularly important for ...
Kathleen Margaret Hagen, Shalina Sheryl Ousman   +1 more
wiley   +1 more source

Related function of mouse SOX3, SOX9, and SRY HMG domains assayed by male sex determination.

, 2000
Sox genes encode proteins related to each other, and to the sex determining gene Sry, by the presence of a DNA binding motif known as the HMG domain. Although HMG domains can bind to related DNA sequences, Sox gene products may achieve target gene ...
Young, M, Eicher, E M, Bergstrom, D E, Albrecht, K H   +3 more
core   +1 more source