Results 141 to 150 of about 39,114 (250)
Oncogenic driver and therapeutic target: Prolactin signalling axis in retroperitoneal sarcoma
Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.Retroperitoneal sarcoma cells can secrete prolactin into the bloodstream, inducing hyperprolactinaemia, which subsequently triggers metabolic reprogramming, such as glucose metabolism. SOX4 can function as a transcription factor that facilitates PRL transcription.
Fu'an Xie +21 more
wiley +1 more source
Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.ABSTRACT Osteoarthritis (OA) remains without disease‐modifying sssstherapies, in part due to biological heterogeneity and a hostile joint microenvironment that undermines one‐size‐fits‐all interventions. Extracellular vesicles (EVs) play a dual role in OA pathophysiology: endogenous EVs disseminate pro‐inflammatory and catabolic signals that propagate ...
Duc‐Hiep Bach +2 more
wiley +1 more source
Journal of Forensic Sciences, Volume 71, Issue 3, Page 1185-1194, May 2026.Abstract Understanding the dynamics of DNA methylation (DNAm) post‐mortem could support forensic applications, particularly the estimation of the post‐mortem interval (PMI), age, and sex of remains. In this study, we investigated DNAm changes in pig carcasses (Sus scrofa) as analogs for human decomposition, while measuring the progression of decay ...
Irina Badell +4 more
wiley +1 more source
Diferenciación sexual del cerebro: Genética vs. epigenética. [PDF]
, 2007 Los cerebros de hembras y machos difieren en varios caracteres fundamentales que apuntan a un mismo fin: maximizar el éxito reproductivo. A lo largo de la evolución varias estrategias han surgido para diferenciar el cerebro en dos fenotipos distintos y ...
Becu, Damasia
core
Opioids in breast cancer: Between analgesia and modulation of tumour progression
British Journal of Pharmacology, Volume 183, Issue 9, Page 1727-1746, May 2026.Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun +2 more
wiley +1 more source
Beyond the chaos: How architecture structures tumour biology
The FEBS Journal, Volume 293, Issue 9, Page 2519-2540, May 2026.Tissue architecture shapes tumour initiation and progression through multiple interconnected layers continuously remodelled over time. This review outlines how physical forces, biochemical cues, cellular niches and systemic influences contribute to tumour evolution.
Lea Dörner +3 more
wiley +1 more source
CTNNB1 Genetic Variation and Its Interaction With DLK1 in Type 2 Diabetes Mellitus
The FASEB Journal, Volume 40, Issue 8, 30 April 2026.This graphical abstract illustrates the integrated study of CTNNB1 and DLK1 interaction in type 2 diabetes mellitus (T2DM). Combining bioinformatics, human genetic analysis, and HFD‐induced mouse models, it shows CTNNB1 and DLK1 synchronous downregulation in T2DM, the protective effect of CTNNB1 rs1798802 GG genotype, and cooperative colocalization of ...
Xiaoxue Gan +5 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 8, 30 April 2026.Enteric glia in humans, mice, and rats express all known receptors for TcdA (LDLR) and TcdB (CSPG4, FZD‐1, FZD2, FZD7, PVRL3, TFPI, LRP1). CSPG4 expression is increased in colonic tissues from humans and mice with C. difficile infection, as well as in rat enteric glia exposed to TcdA or TcdB. C.
Francisco M. S. Marques +5 more
wiley +1 more source