Results 11 to 20 of about 1,607 (189)

Ferroptosis‐Inhibitory Effect and Possible Mechanisms of Ellagitannin Geraniin

ChemistryOpen, 2021
The search for safe and effective ferroptosis‐inhibitors has become an important topic. Geraniin, an ellagitannin bearing hexahydroxydiphenoyl (HHDP) and dehydrohexahydroxydiphenoyl (DHHDP) groups, was observed to inhibit erastin‐induced ferroptosis in ...
Dr. Ban Chen, Prof. Xican Li, Dr. Jie Liu, Yuling Li, Wanjian Dai, Yingci Chen, Prof. Dongfeng Chen   +6 more
doaj   +5 more sources

Geraniin Alleviates High-Fat Diet-Induced Atherosclerosis in <i>ApoE</i> ^-/- Mice. [PDF]

Food Sci Nutr
ABSTRACTGeraniin (GE), an ellagic tannin extracted from Geranium wilfordii, has been demonstrated to improve high‐fat diet‐induced metabolic disorders. This study aimed to investigate the effect of Geraniin on atherosclerosis and the underlying mechanism. In this study, we used the ApoE−/− mice as a model of atherosclerosis.
Xie Y, Liu S, Wei Z, Yu L, Yu J, Xu L, Jiang H, Gu Z.   +7 more
europepmc   +3 more sources

Acute oral toxicity of the ellagitannin geraniin and a geraniin-enriched extract from Nephelium lappaceum L rind in Sprague Dawley rats [PDF]

Heliyon, 2019
Despite the lack of its toxicity evaluation, traditional herbal products are being widely used for various health indications. Geraniin, an ellagitannin, is a bioactive compound found in many traditional herbal medicines.
Mohanambal Moorthy, Joon Joon Khoo, Uma D. Palanisamy   +2 more
doaj   +3 more sources

Identification of the plant compound geraniin as a novel Hsp90 inhibitor. [PDF]

PLoS ONE, 2013
Besides its function in normal cellular growth, the molecular chaperone heat shock protein 90 (Hsp90) binds to a large number of client proteins required for promoting cancer cell growth and/or survival.
Antonio Vassallo, Maria Carmela Vaccaro, Nunziatina De Tommasi, Fabrizio Dal Piaz, Antonella Leone   +4 more
doaj   +5 more sources

Efficacy of geraniin on dengue virus type-2 infected BALB/c mice [PDF]

Virology Journal, 2019
Background Dengue continues to be a major international public health concern. Despite that, there is no clinically approved antiviral for treatment of dengue virus (DENV) infections. In this study, geraniin extracted from the rind of Nephelium lappaceum
Siti Aisyah Abdul Ahmad, Uma D. Palanisamy, Joon Joon Khoo, Amreeta Dhanoa, Sharifah Syed Hassan   +4 more
doaj   +3 more sources

Geraniin Protects High-Fat Diet-Induced Oxidative Stress in Sprague Dawley Rats [PDF]

Frontiers in Nutrition, 2018
Geraniin, a hydrolysable polyphenol derived from Nephelium lappaceum L. fruit rind, has been shown to possess significant antioxidant activity in vitro and recently been recognized for its therapeutic potential in metabolic syndrome.
Alexis Panny Y. S. Chung, Sunil Gurtu, Srikumar Chakravarthi, Mohanambal Moorthy, Uma D. Palanisamy   +4 more
doaj   +3 more sources

Geraniin supplementation increases human keratinocyte proliferation in serum-free culture [PDF]

Universa Medicina, 2013
Background Various products used in cellular therapy utilize tissue culture techniques requiring keratinocyte culture. An efficient and clinically acceptable keratinocyte culture system requires supplements with mitogenic activity.
Indra Kusuma, Restu Syamsul Hadi
doaj   +2 more sources

Mass Spectrometry-Based Applications in Tannin Analytics: From Qualitative and Quantitative Analyses to Biological Activity. [PDF]

Mass Spectrom Rev
ABSTRACT Tannins are widespread specialized plant metabolites that contribute significantly to the polyphenol content of plant‐based diets. Their effects on human and animal health vary depending on their structure, with potential benefits including antioxidative, antimicrobial, anthelmintic, and anticarcinogenic properties.
Engström MT, Karonen M.
europepmc   +2 more sources

In Vitro, In Vivo, and Clinical Trial Approaches to Investigate the Effects of Medicinal Plants on Burn Wound Healing: A Systematic Review. [PDF]

Int Wound J
ABSTRACT Use of synthetic drugs for the treatment of burn wounds has decreased due to adverse effects, and they are gradually being replaced by compounds obtained from natural products, especially medicinal plants. This review focused on pre‐clinical and clinical studies examining the efficacy of medicinal plants in promoting burn wound healing.
Bagheri M, Zarei SM, Soodmand M, Mardani Nafchi H, Hashemi Poor MH.   +4 more
europepmc   +2 more sources

Geraniin Alleviates Mouse Laser-Induced Choroidal Neovascularisation by Inhibiting Choroidal Endothelial Cell ACE2/Ang-(1-7)/MasR/IL-10 Pathway. [PDF]

J Cell Mol Med
ABSTRACT Anti‐vascular endothelial growth factor (VEGF) drugs suppress choroidal neovascularisation (CNV), thus improving vision. However, some patients may have a poor response or develop resistance to anti‐VEGF drugs. Geraniin (GE), a polyphenol isolated from an herb called Phyllanthus amarus, possesses anti‐angiogenic properties. This study aimed to
Lu H, Cai Q, Li L, Gu J, Zhang Y, Sun H, Su H, Song L.   +7 more
europepmc   +2 more sources