Results 101 to 110 of about 4,652 (199)

Asymmetric activation mechanism of a homodimeric red light-regulated photoreceptor

eLife, 2018
Organisms adapt to environmental cues using diverse signaling networks. In order to sense and integrate light for regulating various biological functions, photoreceptor proteins have evolved in a modular way.
Geoffrey Gourinchas, Udo Heintz, Andreas Winkler   +2 more
doaj   +1 more source

Structure and Multitasking of the c-di-GMP-Sensing Cellulose Secretion Regulator BcsE

mBio, 2020
Most bacteria respond to surfaces by biogenesis of intracellular c-di-GMP, which inhibits motility and induces secretion of biofilm-promoting adherence factors.
Samira Zouhir, Wiem Abidi, Meryem Caleechurn, Petya Violinova Krasteva   +3 more
doaj   +1 more source

Reducing Peptidoglycan Crosslinking by Chemical Modulator Reverts β‐lactam Resistance in Methicillin‐Resistant Staphylococcus aureus

Advanced Science, Volume 11, Issue 28, July 24, 2024.
This study provides insight into the mechanism of celastrol as a potentiator of β‐lactams against methicillin‐resistant Staphylococcus aureus (MRSA). Celastrol reduces the cellular c‐di‐AMP level by activating GdpP and increases muropeptides with shorter glycine branches that cannot be processed by PBP2a of MRSA, making MRSA susceptible to β‐lactams ...
Ji‐Hoon Kim, Yunmi Lee, Inseo Kim, JuOae Chang, Subin Hong, Na Kyung Lee, David Shum, Seongeun Baek, Wooseong Kim, Soojin Jang, Wonsik Lee   +10 more
wiley   +1 more source

Discrete cyclic di-GMP-dependent control of bacterial predation versus axenic growth in Bdellovibrio bacteriovorus.

PLoS Pathogens, 2012
Bdellovibrio bacteriovorus is a Delta-proteobacterium that oscillates between free-living growth and predation on Gram-negative bacteria including important pathogens of man, animals and plants.
Laura Hobley, Rowena K Y Fung, Carey Lambert, Maximilian A T S Harris, Jayesh M Dabhi, Simon S King, Simon S King, Sarah M Basford, Kaoru Uchida, Robert Till, Rashidah Ahmad, Shin-Ichi Aizawa, Mark Gomelsky, R Elizabeth Sockett   +13 more
doaj   +1 more source

A cyclic di‐GMP‐binding adaptor protein interacts with a N5‐glutamine methyltransferase to regulate the pathogenesis in Xanthomonas citri subsp. citri

Molecular Plant Pathology, Volume 25, Issue 7, July 2024.
N5MapZ was identified as a key regulator of Xanthomonas citri virulence, interacting with HemK and modulating c‐di‐GMP effects on motility, virulence, enzyme production and stress tolerance. Abstract The second messenger cyclic diguanylate monophosphate (c‐di‐GMP) regulates a wide range of bacterial behaviours through diverse mechanisms and binding ...
Yu Shi, Tianfang Cheng, Qing Wei Cheang, Xiaoyan Zhao, Zeling Xu, Zhao‐Xun Liang, Linghui Xu, Junxia Wang   +7 more
wiley   +1 more source

Dynamic complex formation between HD-GYP, GGDEF and PilZ domain proteins regulates motility in Xanthomonas campestris.

Molecular microbiology, 2013
RpfG is a member of a class of wide spread bacterial two-component regulators with an HD-GYP cyclic di-GMP phosphodiesterase domain. In the plant pathogen Xanthomonas campestris, RpfG together with the sensor kinase RpfC regulates multiple factors as a response to the cell-to-cell Diffusible Signalling Factor (DSF).
Ryan, R, McCarthy, Y, Kiely, P, O'Connor, R, Farah, C, Armitage, J, Dow, J   +6 more
openaire   +3 more sources

The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, [PDF]

, 2014
In nature, the Lyme disease spirochete Borrelia burgdorferi cycles between the unrelated environments of the Ixodes tick vector and mammalian host. In order to survive transmission between hosts, B.
Adams, Adams, Albright, Amikam, Andrade, Armitage, Barends, Barrett, Beier, Benach, Berg, Bian, Blevins, Boardman, Bobrov, Boehm, Boylan, Brisson, Brooks, Brown, Burgdorfer, Burtnick, Caimano, Caimano, Caimano, Carroll, Carroll, Casjens, Chae, Chang, Chang, Charon, Chatterjee, Christen, Christen, Christen, Cotter, Duerig, Dunham-Ems, Fang, Fazli, Fisher, Fraser, Freedman, Fries, Galperin, Galperin, Galperin, Girgis, Goldman, Groshong, Habazettl, HajduÅ¡ek, Hammer, He, He, Hengge, Hickman, Hickman, Hyde, Hyde, Hübner, Jenal, Katona, Kazmierczak, Kim, Ko, Kostick, Krasteva, Kuehn, Kulasekara, Lai, Lane, Lee, Levine, Li, Luo, Maes, Massie, Mather, McCarthy, Merighi, Monds, Moriarty, Motaleb, Motaleb, Nickels, Norman, Ojaimi, Ojaimi, Ostfeld, Ouyang, Ouyang, Ouyang, Ouyang, Pappas, Paul, Paul, Pazy, Pesavento, Pitzer, Pratt, Radolf, Revel, Rogers, Ross, Russell, Ryan, Ryan, Ryan, Ryan, Ryan, Ryjenkov, Ryjenkov, Römling, Römling, Römling, Römling, Samuels, Samuels, Schirmer, Schmidt, Schmidt, Seshu, Silversmith, Smith, Sommerfeldt, Sonenshine, Sonenshine, Stelitano, Stock, Sudarsan, Sultan, Sultan, Sze, Sze, Tal, Tam, Tamayo, Tamayo, Tamayo, Tao, Thomas, Tilly, Tokarz, Trappetti, Tsao, Tuckerman, Tuckerman, Vvedenskaya, Weber, West, Wolfe, Xu, Yang, Yang, Yildiz, Yildiz, Zhang, Zorraquino   +159 more
core   +2 more sources

Dimerisation induced formation of the active site and the identification of three metal sites in EAL-phosphodiesterases [PDF]

, 2017
The bacterial second messenger cyclic di-3′,5′-guanosine monophosphate (c-di-GMP) is a key regulator of bacterial motility and virulence. As high levels of c-di-GMP are associated with the biofilm lifestyle, c-di-GMP hydrolysing phosphodiesterases (PDEs)
A Deepthi, A Sundriyal, A Tchigvintsev, A Ueda, A Vagin, A Winkler, AD Tischler, AD Tischler, AJ Schmidt, B Huang, BW Holloway, C Chan, C Romier, CD Boyd, CW Phippen, D Balasubramanian, D Bellini, DA D’Argenio, DJ Hosfield, DL Caly, EF Pettersen, F Rao, F Rao, G Kuppuraj, G Minasov, G Winter, G Winter, GL Winsor, GN Murshudov, H Ceri, H Kulasakara, H Zheng, I Ivanov, ID Hay, J Robert-Paganin, JH Merritt, K Syson, K-H Choi, KD Miner, KM Thormann, M Christen, M Valentini, M Vorachit, MD Winn, MVAS Navarro, MY Galperin, N Barraud, O Kirillina, P Aldridge, P Emsley, P Evans, PD Newell, PR Evans, R Donlan, R Paul, R Simm, R Tamayo, RM Keegan, RP Ryan, RP Ryan, RZ Liao, TRM Barends, TT Hoang, U Römling, V Stelitano, VB Chen, W Grzybkowski, W Kabsch, Y Li, Y Qi, Y Wang   +70 more
core   +2 more sources

Discovery of Novel c-di-GMP-Related Genes in Leptospira interrogans

Pathogens
Cyclic di-GMP (bis-(3′→5′) cyclic dimeric guanosine monophosphate) is a ubiquitous bacterial second messenger that regulates a wide range of cellular processes, including biofilm formation, motility, virulence, and environmental adaptation.
Anielle Salviano de Almeida Ferrari, Davi Gabriel Salustiano Merighi, Aline Biazola Visnardi, Gabriela Roberto Silva, Cauê Augusto Boneto Gonçalves, Daniel Enrique Sanchez-Limache, Bruna Sayuri Cardoso Ogusku, Anacleto Silva de Souza, Robson Francisco de Souza, Cristiane Rodrigues Guzzo   +9 more
doaj   +1 more source

The Diguanylate Cyclase SadC Is a Central Player in Gac/Rsm-Mediated Biofilm Formation in Pseudomonas aeruginosa

, 2014
Pseudomonas aeruginosa is a Gram-negative opportunistic human pathogen and a threat for immune-compromised and Cystic Fibrosis patients. It is responsible for acute and chronic infections and can switch between these lifestyles upon taking an informed ...
Filloux, A, Hui, K, Jaeger, T, Jenal, U, Moscoso, JA, Valentini, M   +5 more
core   +2 more sources