Results 91 to 100 of about 4,652 (199)

ESM‐scan—A tool to guide amino acid substitutions

Protein Science, Volume 33, Issue 12, December 2024.
Abstract Protein structure prediction and (re)design have gone through a revolution in the last 3 years. The tremendous progress in these fields has been almost exclusively driven by readily available machine learning algorithms applied to protein folding and sequence design problems.
Massimo G. Totaro, Uršula Vide, Regina Zausinger, Andreas Winkler, Gustav Oberdorfer   +4 more
wiley   +1 more source

Virulence and Prodigiosin Antibiotic Biosynthesis inSerratiaAre Regulated Pleiotropically by the GGDEF/EAL Domain Protein, PigX [PDF]

Journal of Bacteriology, 2007
ABSTRACTGram-negative bacteria of the genusSerratiaare opportunistic human, plant, and insect pathogens.Serratiasp. strain ATCC 39006 secretes pectinases and cellulases and produces the secondary metabolites carbapenem and prodigiosin. Mutation of a gene (pigX) resulted in an extremely pleiotropic phenotype: prodigiosin antibiotic biosynthesis, plant ...
Peter C, Fineran, Neil R, Williamson, Kathryn S, Lilley, George P C, Salmond   +3 more
openaire   +2 more sources

The World of Cyclic Dinucleotides in Bacterial Behavior

Molecules, 2020
The regulation of multiple bacterial phenotypes was found to depend on different cyclic dinucleotides (CDNs) that constitute intracellular signaling second messenger systems.
Aline Dias da Purificação, Nathalia Marins de Azevedo, Gabriel Guarany de Araujo, Robson Francisco de Souza, Cristiane Rodrigues Guzzo   +4 more
doaj   +1 more source

High‐quality genome of a novel Thermosynechococcaceae species from Namibia and characterization of its protein expression patterns at elevated temperatures

MicrobiologyOpen, Volume 13, Issue 5, October 2024.
In this study, the genome of a new thermophilic cyanobacterium, Thermosynechococcaceae cyanobacterium sp. Okahandja, isolated from a hot spring near Okahandja in Namibia, was sequenced. Additionally, cultivations were conducted at elevated temperatures of 40, 50, and 55°C, followed by analyses of the respective adapted proteomes based on the annotated ...
Nathanael D. Arnold, Michael Paper, Tobias Fuchs, Nadim Ahmad, Patrick Jung, Michael Lakatos, Katia Rodewald, Bernhard Rieger, Farah Qoura, Martha Kandawa‐Schulz, Norbert Mehlmer, Thomas B. Brück   +11 more
wiley   +1 more source

Functional analysis of GGDEF-EAL didomain-containing proteins in cyclic-di-GMP signaling [PDF]

, 2019
Cylic-di-GMP (c-di-GMP) is a ubiquitous bacterial second messenger that regulates twitching motility, virulence secretion, cell surface adhesion and biofilm formation. The intracellular concentrations of c-di-GMP are regulated by various GGDEF/EAL domain-containing proteins.
openaire   +2 more sources

Characterization of c‐di‐AMP signaling in the periodontal pathobiont, Treponema denticola

Molecular Oral Microbiology, Volume 39, Issue 5, Page 354-367, October 2024.
Abstract Pathobionts associated with periodontitis, such as Treponema denticola, must possess numerous sensory transduction systems to adapt to the highly dynamic subgingival environment. To date, the signaling pathways utilized by T. denticola to rapidly sense and respond to environmental stimuli are mainly unknown.
Aidan D. Moylan, Dhara T. Patel, Claire O'Brien, Edward J. A. Schuler, Annie N. Hinson, Richard T. Marconi, Daniel P. Miller   +6 more
wiley   +1 more source

Cyclic di-GMP-dependent signaling pathways in the pathogenic Firmicute Listeria monocytogenes.

PLoS Pathogens, 2014
We characterized key components and major targets of the c-di-GMP signaling pathways in the foodborne pathogen Listeria monocytogenes, identified a new c-di-GMP-inducible exopolysaccharide responsible for motility inhibition, cell aggregation, and ...
Li-Hong Chen, Volkan K Köseoğlu, Zehra T Güvener, Tanya Myers-Morales, Joseph M Reed, Sarah E F D'Orazio, Kurt W Miller, Mark Gomelsky   +7 more
doaj   +1 more source

Hot and crispy : CRISPR-Cas systems in the hyperthermophile Sulfolobus solfataricus [PDF]

, 2013
The CRISPR (clustered regularly interspaced short palindromic repeats) and Cas (CRISPR-associated) genes are widely spread in bacteria and archaea, representing an intracellular defence system against invading viruses and plasmids.
White, Malcolm F., Zhang, Jing
core   +2 more sources

Photophobotaxis in the filamentous cyanobacterium Phormidium lacuna: Mechanisms and implications for photosynthesis‐based light direction sensing

Photochemistry and Photobiology, Volume 100, Issue 5, Page 1290-1309, September/October 2024.
How do filaments of Phormidium lacuna find the lighted area? Each filament moves in random direction. If a filament crosses the light–dark border, it returns and stays in the light. Abstract Cyanobacterium Phormidium lacuna filaments move from dark to illuminated areas by twitching motility.
Elina Schwabenland, Caroline Janine Jelen, Nora Weber, Tilman Lamparter   +3 more
wiley   +1 more source

Formation of a complex between HD-GYP, GGDEF and PilZ domain proteins regulates motility in Xanthomonas campestris

Microbiology Research, 2018
RpfG is a member of a class of wide spread bacterial two-component regulators with an HD-GYP cyclic di-GMP phosphodiesterase domain. In the plant pathogen Xanthomonas campestris pv. campestris (Xcc), RpfG together with the sensor kinase RpfC regulates the synthesis of a range of virulence factors as a response to the cell-cell Diffusible Signaling ...
Shi-qi An, Ji-liang Tang
openaire   +2 more sources