Results 71 to 80 of about 4,652 (199)

Engineering Bacteria as Living Therapeutics in Cancer Therapy

Advanced Science, Volume 12, Issue 42, November 13, 2025.
Through synthetic biology approaches, natural bacteria can be genetically programmed into multifunctional living therapeutics. These engineered bacteria are capable of secreting anti‐tumor factors, displaying tumor‐associated antigens on their surface, or undergoing programmed self‐lysis to release therapeutic cargo.
Jiangfeng Chen, Jiaqi Chen, Yixuan Chen, Wenxuan Yuan, Jiao Zhang, Guoqing Wang, Zhuojun Dai   +6 more
wiley   +1 more source

A messenger molecule governs interdependency in an evolved Pseudomonas aeruginosa biofilm community [PDF]

, 2011
Biofilm populations are known to harbor great diversity, but the importance of this diversity is not fully understood. A likely contributor to this variation is the second messenger molecule cyclic-di-GMP: low levels associate with a planktonic lifestyle
Johnson, Thomas MacElliott
core   +1 more source

Antibiotic Persister Cells in Acinetobacter baumannii: Overview of Molecular Mechanisms and Removal Strategies

Environmental Microbiology, Volume 27, Issue 11, November 2025.
Antibiotic persister cells in Acinetobacter baumannii: review of the molecular mechanisms involved in this physiology, such as toxin/antitoxin, second messengers, SOS response, PAA or membranes; and elimination strategies such as antibiotics or phages.
Delphine Vergoz, Emmanuelle Dé, Corinne Loutelier‐Bourhis, Stéphane Alexandre   +3 more
wiley   +1 more source

Identification of DR75-RS11090 Gene Encoding GGDEF Domains, and its Role in Enterococcus faecalis

Jundishapur Journal of Microbiology, 2019
Background: Enterococcus faecalis is considered the primary pathogenic bacteria in failed root canal therapy due to its excellent biofilm formation ability. The second messenger cyclic dimeric (3’→5’) GMP (c-di-GMP) is involved in bacterial physiological processes, including biofilm formation.
Luna Fan, Xiang Ben Hou
openaire   +2 more sources

Hierarchical involvement of various GGDEF domain proteins in rdar morphotype development of Salmonella enterica serovar Typhimurium [PDF]

Molecular Microbiology, 2006
SummaryGGDEF and EAL domain proteins are involved in the turnover of the novel secondary messenger cyclic‐di(3′→5′)‐guanylic acid (c‐di‐GMP) in many bacteria. In this work the role of the 12 GGDEF domain proteins encoded by the Salmonella enterica serovar Typhimurium (S.
Kader, Abdul, Simm, Roger, Gerstel, Ulrich, Morr, Michael, Römling, Ute   +4 more
openaire   +3 more sources

Genetic dissection of Escherichia coli's master diguanylate cyclase DgcE: Role of the N-terminal MASE1 domain and direct signal input from a GTPase partner system.

PLoS Genetics, 2019
The ubiquitous second messenger c-di-GMP promotes bacterial biofilm formation by playing diverse roles in the underlying regulatory networks. This is reflected in the multiplicity of diguanylate cyclases (DGC) and phosphodiesterases (PDE) that synthesize
Vanessa Pfiffer, Olga Sarenko, Alexandra Possling, Regine Hengge   +3 more
doaj   +1 more source

Biofilms and cyclic di-GMP (c-di-GMP) signaling: lessons from Pseudomonas aeruginosa and other bacteria

, 2016
The cyclic di-GMP (c-di-GMP) second messenger represents a signaling system that regulates many bacterial behaviors and is of key importance for driving the lifestyle switch between motile loner cells and biofilm formers.
Filloux, A, Valentini, M
core   +2 more sources

STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection. [PDF]

, 2013
UnlabelledSTING (stimulator of interferon [IFN] genes) initiates type I IFN responses in mammalian cells through the detection of microbial nucleic acids. The membrane-bound obligate intracellular bacterium Chlamydia trachomatis induces a STING-dependent
Barker, Jeffrey R, Burdette, Dara L, Carpenter, Victoria K, Koestler, Benjamin J, Valdivia, Raphael H, Vance, Russell E, Waters, Christopher M   +6 more
core   +2 more sources

Towards the control of biofilm formation in Anabaena (Nostoc) sp. PCC7120: novel insights into the genes involved and their regulation

New Phytologist, Volume 247, Issue 4, Page 1805-1825, August 2025.
Summary Cyanobacteria are major components of biofilms in light‐exposed environments, contributing to nutrient cycling, nitrogen fixation and global biogeochemical processes. Although nitrogen‐fixing cyanobacteria have been successfully used in biofertilization, the regulatory mechanisms underlying biofilm formation remain poorly understood.
Irene Olivan‐Muro, Jorge Guío, Germán Alonso‐Tolo, Emma Sevilla, María F. Fillat   +4 more
wiley   +1 more source

Progress in understanding of the molecular basis underlying functional diversification of cyclic di-nucleotide turnover proteins [PDF]

, 2016
Cyclic di-GMP was the first cyclic di-nucleotide second messenger described, presaging the discovery of additional cyclic di-nucleotide messengers in bacteria and eukaryotes.
Dow, J. Maxwell, Liang, Zhao-Xun, Römling, Ute   +2 more
core   +1 more source