Results 71 to 80 of about 2,948 (189)

Genetic reductionist approach for dissecting individual roles of GGDEF proteins within the c-di-GMP signaling network in Salmonella [PDF]

, 2009
Bacteria have developed an exclusive signal transduction system involving multiple diguanylate cyclase and phosphodiesterase domain-containing proteins (GGDEF and EAL/HD-GYP, respectively) that modulate the levels of the same diffusible molecule, 3 -5 ...
Latasa, Cristina, Casals, Joan, Valle Turrillas, Jaione, Pedroso, Enrique, Toledo-Arana, Alejandro, García Martínez, Begoña, Solano Goñi, Cristina, Zorraquino Salvo, Violeta, Latasa Osta, Cristina, García, Begoña, Zorraquino, Violeta, Lasa Uzcudun, Íñigo, Lasa, Íñigo, Solano, Cristina, Toledo Arana, Alejandro   +14 more
core   +1 more source

Rôle des protéines à domaines GGDEF et/ou EAL chez Legionella pneumophila

, 2011
Legionella pneumophila is an intracellular pathogen found in aquatic environments where it replicates in protozoan hosts. My objectives were to identify molecular mechanisms that control virulence and multidrug resistance in L.
Levet-Paulo, Mélanie, Levet, Levet-Paulo, Mélanie,   +1 more
core   +3 more sources

Genetic dissection of Escherichia coli's master diguanylate cyclase DgcE: Role of the N-terminal MASE1 domain and direct signal input from a GTPase partner system.

PLoS Genetics, 2019
The ubiquitous second messenger c-di-GMP promotes bacterial biofilm formation by playing diverse roles in the underlying regulatory networks. This is reflected in the multiplicity of diguanylate cyclases (DGC) and phosphodiesterases (PDE) that synthesize
Vanessa Pfiffer, Olga Sarenko, Alexandra Possling, Regine Hengge   +3 more
doaj   +1 more source

Towards the control of biofilm formation in Anabaena (Nostoc) sp. PCC7120: novel insights into the genes involved and their regulation

New Phytologist, Volume 247, Issue 4, Page 1805-1825, August 2025.
Summary Cyanobacteria are major components of biofilms in light‐exposed environments, contributing to nutrient cycling, nitrogen fixation and global biogeochemical processes. Although nitrogen‐fixing cyanobacteria have been successfully used in biofertilization, the regulatory mechanisms underlying biofilm formation remain poorly understood.
Irene Olivan‐Muro, Jorge Guío, Germán Alonso‐Tolo, Emma Sevilla, María F. Fillat   +4 more
wiley   +1 more source

Dynamic complex formation between HD-GYP, GGDEF and PilZ domain proteins regulates motility in Xanthomonas campestris

, 2012
RpfG is a member of a class of wide spread bacterial two-component regulators with an HD-GYP cyclic di-GMP phosphodiesterase domain. In the plant pathogen Xanthomonas campestris, RpfG together with the sensor kinase RpfC regulates multiple factors as a ...
Farah, CS, Armitage, JP, Dow, J. Maxwell, McCarthy, Y, O'Connor, Rosemary, Ryan, Robert P., McCarthy, Yvonne, Armitage, Judith, Armitage, Judith P., Dow, JM, O'Connor, R, Kiely, Patrick A., Ryan, RP, Farah, Chuck S., Kiely, PA   +14 more
core   +1 more source

NMR Solution Structure of the N‐Terminal GSPII Domain from the Thermus Thermophilus Traffic ATPase PilF and Reconstruction of its c‐di‐GMP Binding Capability

ChemBioChem, Volume 26, Issue 7, April 1, 2025.
GSPII‐A is the first of three consecutive GSPII domains of PilF from Thermus thermophilus and the only one that does not bind c‐di‐GMP. In this study we solve the structure of GSPII‐A and show the key factors hindering c‐di‐GMP binding. Through mutagenesis, we elucidate the minimal motif conservation needed for c‐di‐GMP recognition. Abstract The cyclic
Konstantin Neißner, Carolin Frohnapfel, Heiko Keller, Elke Duchardt‐Ferner, Vanessa Schneider, Zeinab Kamjou, Beate Averhoff, Jens Wöhnert   +7 more
wiley   +1 more source

Characterization and analysis of a novel diguanylate cyclase PA0847 from Pseudomonas aeruginosa PAO1

Infection and Drug Resistance, 2019
Yan Zhang,1,2 Jiayi Guo,1 Ning Zhang,2 Wensu Yuan,2 Zhi Lin,2 Weidong Huang11Department of Biochemistry and Molecular Biology, School of Basic Medicine, Ningxia Medical University, Yinchuan 750004, People’s Republic of China; 2School of Life ...
Zhang Y, Guo J, Zhang N, Yuan W, Lin Z, Huang W   +5 more
doaj  

A GGDEF and EAL domain-containing protein in Pseudomonas syringae pv. actinidiae regulates virulence via its diguanylate cyclase activity

Phytopathology Research
Kiwifruit bacterial canker (KBC), caused by Pseudomonas syringae pv. actinidiae (Psa), poses a severe threat to the global kiwifruit industry, highlighting the urgent need to elucidate its pathogenic mechanisms. Cyclic diguanylate monophosphate (c-di-GMP)
Yudi Wang, Mingming Yang, Jinfang Zhou, Xianwei Xie, Jiabing Ma, Yao Wang, Xihui Shen, Lili Huang   +7 more
doaj   +1 more source

Presence of a classical RRM-fold palm domain in Thg1-type 3'- 5'nucleic acid polymerases and the origin of the GGDEF and CRISPR polymerase domains

Biology Direct, 2010
Background Almost all known nucleic acid polymerases catalyze 5'-3' polymerization by mediating the attack on an incoming nucleotide 5' triphosphate by the 3'OH from the growing polynucleotide chain in a template dependent or independent manner. The only
Aravind L, Iyer Lakshminarayan M, Anantharaman Vivek   +2 more
doaj   +1 more source

Co‐Existence Slows Diversification in Experimental Populations of E. coli and P. fluorescens

Environmental Microbiology, Volume 27, Issue 2, February 2025.
Escherichia coli and Pseudomonas fluorescens were cultured in monoculture and co‐culture for 8 weeks. Both species diversified in monoculture, while sequencing revealed mutations in P. fluorescens that were enriched in co‐culture with E. coli. A sequencing‐based invasion assay of 16S amplicons revealed that mutations in the PFLU_1661 gene confer the ...
Gareth Howells, Aysha L. Sezmis, Christopher Blake, Michael J. McDonald   +3 more
wiley   +1 more source