Results 71 to 80 of about 3,106 (185)

Virulence and Prodigiosin Antibiotic Biosynthesis inSerratiaAre Regulated Pleiotropically by the GGDEF/EAL Domain Protein, PigX [PDF]

Journal of Bacteriology, 2007
ABSTRACTGram-negative bacteria of the genusSerratiaare opportunistic human, plant, and insect pathogens.Serratiasp. strain ATCC 39006 secretes pectinases and cellulases and produces the secondary metabolites carbapenem and prodigiosin. Mutation of a gene (pigX) resulted in an extremely pleiotropic phenotype: prodigiosin antibiotic biosynthesis, plant ...
Peter C, Fineran, Neil R, Williamson, Kathryn S, Lilley, George P C, Salmond   +3 more
openaire   +2 more sources

To Move or Not to Move: When and How Bacteria Suppress Flagellar Motility

Molecular Microbiology, Volume 126, Issue 2, Page 173-189, August 2026.
Motility cessation in bacteria is a key regulatory strategy that provides multiple survival advantages including enhanced community cooperation, niche adaptation and evasion of host immune responses. This process is controlled by associated mechanisms such as post‐translational modifications and second messenger signalling that stabilise non‐motile ...
Fatemeh Mohaghegh, Jacob Scadden, Matthew A. B. Baker   +2 more
wiley   +1 more source

Binding affinity for nucleotides and enzymatic activity of YfiN_HAMP-GGDEF and YfiN_GGDEF.

, 2013
For all ITC experiments upper panels show the Raw ITC data, while lower panels show the integrated peak areas (black square) fitted with the one-binding-site model of ORIGIN provided by MicroCal (continuous lines).
Stefano Franceschini (488912), Alessandro Paiardini (59368), Silvia Fernicola (488911), Serena Rinaldo (459402), Valentina Stelitano (459399), Francesca Cutruzzolà (459401), Giorgio Giardina (182340)   +6 more
core   +1 more source

Pharmacological Evaluation of Methanolic Fruit Extract of Lannea coromandelica: Antioxidant, Cytotoxic, Antidiabetic, Antibacterial, Anti‐Inflammatory, and Sedative Activities

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Phytochemical investigation of Lannea coromandelica through GC–MS and in silico analysis revealed diverse bioactive compounds with promising pharmacological potential. Integrated in vitro and in vivo assays demonstrated significant antioxidant, antidiabetic, antibacterial, anti‐inflammatory, and sedative activities, supporting its therapeutic relevance.
Priota Islam Meem, Zobayed Islam, Nazmul Hasan Eshaque, Md. Jahirul Islam Mamun, Khurram Murad Mojidee, Mohammad Badrudduja, Amit Kumar Dam, S. M. Moazzem Hossen   +7 more
wiley   +1 more source

The MarR Family Transcriptional Regulator EmrR Negatively Regulates the Type III Secretion System (T3SS) and Positively Modulates Pathogenicity in Dickeya oryzae

Molecular Plant Pathology, Volume 27, Issue 4, April 2026.
This study revealed that the transcriptional regulator EmrR in Dickeya oryzae modulates virulence by regulating hrpL expression and c‐di‐GMP levels. It affects motility, biofilm formation, cellulase production and pathogenicity. EMSA and footprinting confirmed EmrR binds directly to the promoter of its target operon.
Mingfa Lv, Wenqi Huang, Ziwei Meng, Xiaojing Fan, Peng Li, Zeling Xu, Shaohua Chen, Xiaoyuan Chen, Jianuan Zhou, Lianhui Zhang, Yingying Cheng, Tao Zhuo, Ming Hu   +12 more
wiley   +1 more source

XCC2731, a GGDEF domain protein in Xanthomonas campestris, is involved in bacterial attachment and is positively regulated by Clp

Microbiological Research, 2011
In Xanthomonas campestris pv. campestris (Xcc), which is the causative agent of black rot in crucifers, the virulence factor level is substantially decreased in the mutant deficient in RpfG, a phosphodiesterase that degrades the second messenger cyclic di-GMP. The rpfG mutant also grew in an aggregated state.
Hsiao, Yi-Min, Liu, Yu-Fan, Fang, Mei-Chiung, Song, Wan-Ling   +3 more
openaire   +2 more sources

The Diverse Roles of the Histone‐Like Nucleoid Structuring (H‐NS) Protein in Vibrio parahaemolyticus

Genetics Research , Volume 2026, Issue 1, 2026.
The histone‐like nucleoid structuring (H‐NS) protein is a global transcriptional regulator critical for bacterial genome organization and gene expression. In Vibrio parahaemolyticus, H‐NS represses virulence factors such as thermostable direct hemolysin (TDH), type III secretion systems (T3SS1/T3SS2), and type VI secretion systems (T6SS1/T6SS2).
Hao Tang, Yiquan Zhang, Richa Sharma
wiley   +1 more source

Structural and functional studies of STM3615 from Salmonella enterica: a GGDEF-EAL-containing protein involved in c-di-GMP biosynthesis

, 2016
A formação de biofilmes bacterianos é um fenômeno bem conhecido, caracterizado pela formação de uma comunidade bacteriana estática, embebida em uma matriz exopolimérica, regulada pela molécula sinalizadora c-di-GMP.
Rosseto, Flávio Rodolfo
core   +1 more source

The dual GGDEF/EAL domain enzyme PA0285 is a Pseudomonas species housekeeping phosphodiesterase regulating early attachment and biofilm architecture [PDF]

Bacterial lifestyles depend on conditions encountered during colonization. The transition between planktonic and biofilm growth is dependent on the intracellular second messenger c-di-GMP.
Steinchen, Wieland, To, Ka Ning, Freibert, Sven Andreas, Freibert, Sven-Andreas, Givskov, Michael, Eilers, Kira, Hui Yong, Adeline Mei, Brizuela, Jaime, Liu, Xianghui, Hoong Yam, Joey Kuok, Paracuellos, Patricia, Morton, Richard, Goh, Yu Fen, Rice, Scott A., Yam, Joey Kuok Hoong, Filloux, Alain, To, Ka-Ning, Bange, Gert, Rice, Scott A, Yong, Adeline Mei Hui, Liu, X, Steinchen, W, Filloux, A, Brizuela, J, Givskov, M, Hoong Yam, JK, Freibert, S-A, Rice, SA, Eilers, K, Paracuellos, P, Morton, R, Hui Yong, AM, To, K-N, Goh, YF, Bange, G   +34 more
core   +2 more sources

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, Volume 599, Issue 23, Page 3417-3443, December 2025.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source