Results 61 to 70 of about 2,948 (189)

Genetic Determinants Associated With the Biofilm Formation Impairment in Pseudomonas aeruginosa Clinical Isolates

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Numerous studies have reported biofilm formation impairment in Pseudomonas aeruginosa clinical isolates, however, the genetic basis of this phenomenon remains largely unexplored. In this study, we aimed to identify associations between impaired‐biofilm formation and loss‐of‐function mutations in biofilm regulatory and effector genes.
Andrei V. Vvedenskii, Alina S. Ivkina, Dmitry N. Konanov, Tatiana A. Savinova, Ludmila S. Fedorova, Elena N. Ilina   +5 more
wiley   +1 more source

Characterisation of Variants of Cyclic di-GMP Turnover Proteins Associated with Semi-Constitutive rdar Morphotype Expression in Commensal and Uropathogenic Escherichia coli Strains

Microorganisms, 2023
Expression of rdar (red, dry, and rough) colony morphology-based biofilm formation in Escherichia coli is highly variable. To investigate the molecular mechanisms of semi-constitutive rdar morphotype formation, we compared their cyclic di-GMP turnover ...
Annika Cimdins-Ahne, Ali-Oddin Naemi, Fengyang Li, Roger Simm, Ute Römling   +4 more
doaj   +1 more source

Additional file 3 of In silico comparative analysis of GGDEF and EAL domain signaling proteins from the Azospirillum genomes

, 2018
Table S3 and Table S4. Table S3. Repertoire of GGDEF, EAL and GGDEF-EAL predicted proteins, organization, and domain architectures found in the selected Azospirillum spp. genomes. Table S4.
Beatriz Baca (4927294), César Pacheco (4927291), Alberto Mata (4927297), José Cruz Pérez (4927300), Martha Sáenz (4927288)   +4 more
core   +1 more source

The Structure of an Unconventional HD-GYP Protein from Bdellovibrio Reveals the Roles of Conserved Residues in this Class of Cyclic-di-GMP Phosphodiesterases

mBio, 2011
Cyclic-di-GMP is a near-ubiquitous bacterial second messenger that is important in localized signal transmission during the control of various processes, including virulence and switching between planktonic and biofilm-based lifestyles.
Andrew L. Lovering, Michael J. Capeness, Carey Lambert, Laura Hobley, R. Elizabeth Sockett   +4 more
doaj   +1 more source

Diguanylate Cyclases in Vibrio cholerae: Essential Regulators of Lifestyle Switching

Frontiers in Cellular and Infection Microbiology, 2020
Biofilm formation in Vibrio cholerae empowers the bacteria to lead a dual lifestyle and enhances its infectivity. While the formation and dispersal of the biofilm involves multiple components—both proteinaceous and non-proteinaceous, the key to the ...
Sumit Biswas, Om Prakash Chouhan, Divya Bandekar   +2 more
doaj   +1 more source

Identification of the core c-di-GMP turnover proteins responsible for root colonization of Bacillus velezensis

iScience, 2022
Summary: Root colonization by beneficial rhizobacteria determines their plant beneficial effects. The messenger c-di-GMP is involved in the bacterial transition process between motility and biofilm, which are crucial to the colonization ability of the ...
Xiaoyan Dong, Chen Tu, Yanan Liu, Ruifu Zhang, Yunpeng Liu   +4 more
doaj   +1 more source

Engineering Bacteria as Living Therapeutics in Cancer Therapy

Advanced Science, Volume 12, Issue 42, November 13, 2025.
Through synthetic biology approaches, natural bacteria can be genetically programmed into multifunctional living therapeutics. These engineered bacteria are capable of secreting anti‐tumor factors, displaying tumor‐associated antigens on their surface, or undergoing programmed self‐lysis to release therapeutic cargo.
Jiangfeng Chen, Jiaqi Chen, Yixuan Chen, Wenxuan Yuan, Jiao Zhang, Guoqing Wang, Zhuojun Dai   +6 more
wiley   +1 more source

Antibiotic Persister Cells in Acinetobacter baumannii: Overview of Molecular Mechanisms and Removal Strategies

Environmental Microbiology, Volume 27, Issue 11, November 2025.
Antibiotic persister cells in Acinetobacter baumannii: review of the molecular mechanisms involved in this physiology, such as toxin/antitoxin, second messengers, SOS response, PAA or membranes; and elimination strategies such as antibiotics or phages.
Delphine Vergoz, Emmanuelle Dé, Corinne Loutelier‐Bourhis, Stéphane Alexandre   +3 more
wiley   +1 more source

XCC2731, a GGDEF domain protein in Xanthomonas campestris, is involved in bacterial attachment and is positively regulated by Clp

Microbiological Research, 2011
In Xanthomonas campestris pv. campestris (Xcc), which is the causative agent of black rot in crucifers, the virulence factor level is substantially decreased in the mutant deficient in RpfG, a phosphodiesterase that degrades the second messenger cyclic di-GMP. The rpfG mutant also grew in an aggregated state.
Hsiao, Yi-Min, Liu, Yu-Fan, Fang, Mei-Chiung, Song, Wan-Ling   +3 more
openaire   +2 more sources

Additional file 4 of In silico comparative analysis of GGDEF and EAL domain signaling proteins from the Azospirillum genomes

, 2018
Table S5 and Table S6. Table 5. Repertoire of GGDEF and GGDEF-EAL (hybrid) predicted proteins, organization, and domain architectures represented exclusively in the A. halopraeferens, A. thiophilum, and A. oryzae genomes. Table 6.
Beatriz Baca (4927294), César Pacheco (4927291), Alberto Mata (4927297), José Cruz Pérez (4927300), Martha Sáenz (4927288)   +4 more
core   +1 more source