Results 61 to 70 of about 3,043 (159)

Genetic Determinants Associated With the Biofilm Formation Impairment in Pseudomonas aeruginosa Clinical Isolates

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Numerous studies have reported biofilm formation impairment in Pseudomonas aeruginosa clinical isolates, however, the genetic basis of this phenomenon remains largely unexplored. In this study, we aimed to identify associations between impaired‐biofilm formation and loss‐of‐function mutations in biofilm regulatory and effector genes.
Andrei V. Vvedenskii, Alina S. Ivkina, Dmitry N. Konanov, Tatiana A. Savinova, Ludmila S. Fedorova, Elena N. Ilina   +5 more
wiley   +1 more source

Characterization and analysis of a novel diguanylate cyclase PA0847 from Pseudomonas aeruginosa PAO1

Infection and Drug Resistance, 2019
Yan Zhang,1,2 Jiayi Guo,1 Ning Zhang,2 Wensu Yuan,2 Zhi Lin,2 Weidong Huang11Department of Biochemistry and Molecular Biology, School of Basic Medicine, Ningxia Medical University, Yinchuan 750004, People’s Republic of China; 2School of Life ...
Zhang Y, Guo J, Zhang N, Yuan W, Lin Z, Huang W   +5 more
doaj  

A GGDEF and EAL domain-containing protein in Pseudomonas syringae pv. actinidiae regulates virulence via its diguanylate cyclase activity

Phytopathology Research
Kiwifruit bacterial canker (KBC), caused by Pseudomonas syringae pv. actinidiae (Psa), poses a severe threat to the global kiwifruit industry, highlighting the urgent need to elucidate its pathogenic mechanisms. Cyclic diguanylate monophosphate (c-di-GMP)
Yudi Wang, Mingming Yang, Jinfang Zhou, Xianwei Xie, Jiabing Ma, Yao Wang, Xihui Shen, Lili Huang   +7 more
doaj   +1 more source

Engineering Bacteria as Living Therapeutics in Cancer Therapy

Advanced Science, Volume 12, Issue 42, November 13, 2025.
Through synthetic biology approaches, natural bacteria can be genetically programmed into multifunctional living therapeutics. These engineered bacteria are capable of secreting anti‐tumor factors, displaying tumor‐associated antigens on their surface, or undergoing programmed self‐lysis to release therapeutic cargo.
Jiangfeng Chen, Jiaqi Chen, Yixuan Chen, Wenxuan Yuan, Jiao Zhang, Guoqing Wang, Zhuojun Dai   +6 more
wiley   +1 more source

Presence of a classical RRM-fold palm domain in Thg1-type 3'- 5'nucleic acid polymerases and the origin of the GGDEF and CRISPR polymerase domains

Biology Direct, 2010
Background Almost all known nucleic acid polymerases catalyze 5'-3' polymerization by mediating the attack on an incoming nucleotide 5' triphosphate by the 3'OH from the growing polynucleotide chain in a template dependent or independent manner. The only
Aravind L, Iyer Lakshminarayan M, Anantharaman Vivek   +2 more
doaj   +1 more source

Antibiotic Persister Cells in Acinetobacter baumannii: Overview of Molecular Mechanisms and Removal Strategies

Environmental Microbiology, Volume 27, Issue 11, November 2025.
Antibiotic persister cells in Acinetobacter baumannii: review of the molecular mechanisms involved in this physiology, such as toxin/antitoxin, second messengers, SOS response, PAA or membranes; and elimination strategies such as antibiotics or phages.
Delphine Vergoz, Emmanuelle Dé, Corinne Loutelier‐Bourhis, Stéphane Alexandre   +3 more
wiley   +1 more source

Dynamic complex formation between HD-GYP, GGDEF and PilZ domain proteins regulates motility in Xanthomonas campestris

, 2012
RpfG is a member of a class of wide spread bacterial two-component regulators with an HD-GYP cyclic di-GMP phosphodiesterase domain. In the plant pathogen Xanthomonas campestris, RpfG together with the sensor kinase RpfC regulates multiple factors as a ...
Farah, CS, Armitage, JP, Dow, J. Maxwell, McCarthy, Y, O'Connor, Rosemary, Ryan, Robert P., McCarthy, Yvonne, Armitage, Judith, Armitage, Judith P., Dow, JM, O'Connor, R, Kiely, Patrick A., Ryan, RP, Farah, Chuck S., Kiely, PA   +14 more
core   +1 more source

Systematic nomenclature for GGDEF and EAL domain-containing Cyclic di-GMP turnover proteins of Escherichia coli [PDF]

, 2016
In recent years, Escherichia coli has served as one of a handful of model bacterial species for studying c-di-GMP signaling. The widely used E. coli K-12 laboratory strains possesses 29 genes encoding proteins with GGDEF and/or EAL domains, which include
Gomelsky, Mark, Green, Jeffrey, K. T. Hughes, M. Gomelsky, Hughes, Kelly, U. Jenal, J. Green, Hengge, Regine, Galperin, Michael Y., Hughes, Kelly T., R. Hengge, M. Y. Galperin, P. Landini, Landini, Paolo, Jenal, Urs, J. Ghigo, Galperin, Michael, Ghigo, Jean-Marc   +17 more
core   +1 more source

Identification of a cyclic-di-GMP-modulating response regulator that impacts biofilm formation in a model sulfate reducing bacterium

Frontiers in Microbiology, 2014
We surveyed the eight putative cyclic-di-GMP-modulating response regulators (RRs) in Desulfovibrio vulgaris Hildenborough that are predicted to function via two-component signaling.
Lara eRajeev, Eric G Luning, Sara eAltenburg, Grant Matthew Zane, Edward E Baidoo, Michela eCatena, Jay D Keasling, Jay D Keasling, Judy D Wall, Matthew W Fields, Aindrila eMukhopadhyay   +10 more
doaj   +1 more source

The World of Cyclic Dinucleotides in Bacterial Behavior

Molecules, 2020
The regulation of multiple bacterial phenotypes was found to depend on different cyclic dinucleotides (CDNs) that constitute intracellular signaling second messenger systems.
Aline Dias da Purificação, Nathalia Marins de Azevedo, Gabriel Guarany de Araujo, Robson Francisco de Souza, Cristiane Rodrigues Guzzo   +4 more
doaj   +1 more source