Results 51 to 60 of about 21,869 (301)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Determining the best possible programming options for gifted and talented students in small rural school districts [PDF]

, 2002
Plan BThe education of gifted and talented students is an area that has long been neglected in public education systems. Due to extreme demands on the educational system, special programs often do not receive the attention they need and deserve. This has
Schneider, Ann Keller
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Gifted Education in Hong Kong: A School-Based Support Program Catering to Learner Diversity

ECNU Review of Education, 2020
Purpose: This study explores the contributions and effectiveness of the Jockey Club “Giftedness into Flourishing Talents” Project (Project GIFT) in supporting learner diversity in gifted education, including meeting the educational and psychological ...
Ruby S. H. Cheung, Anna N. N. Hui, Alan C. K. Cheung   +2 more
doaj   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Preparing special educators to teach second language to students with learning disabilities in the United Arab Emirates: an experimental study

Cogent Education
Consistently, it has been reported that children with disabilities struggle to acquire literacy skills. Although there is evidence that students with learning disability are not given requisite support in classrooms, there is limited research on training
Maxwell Peprah Opoku, Maria Efstratopoulou, Fatima Alkatheeri, Haseena Shah, Lydia Haitham Kasem, Amina Khurshid, Eleana Charalambous, Ashraf Moustafa   +7 more
doaj   +1 more source

REGIONAL MANAGEMENT SYSTEM MODEL IN EDUCATING GIFTED CHILDREN

Sovremennye Issledovaniâ Socialʹnyh Problem, 2018
Subject: modeling and managing extended support and development of gifted children in their education. Aim: the rationale and creation of a regional management system model of activities for educating gifted children, which will enable their real and ...
Galina Leonidovna Parfenova, Svetlana Vladislavovna Kolesova   +1 more
doaj   +1 more source

A study of leadership development programme for gifted primary school students in South Korea [PDF]

, 2008
This thesis investigates leadership development in the gifted primary school students of South Korea. It ultimately aims to make suggestions toward the formulation and implementation of a model leadership gifted curriculum and programme specific to the ...
Ahn, Seung Hee
core